Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns

• Main Author: Fonseca, Fernanda Andrade Macaferri da
• Publication Date: 2022
• Other Authors: Espósito, Aline Paulino, Silva, Maria Helena Baptista Nunes da, Nunes, Valéria Sutti, Cazita, Patricia Miralda, Ferreira, Guilherme Silva, Ceccon, Maria Esther Jurfest Rivero, Carvalho, Werther Brunow de, Carneiro-Sampaio, Magda, Palmeira, Patricia
• Format: Article
• Language: eng
• Source: Clinics
• Download full: https://www.revistas.usp.br/clinics/article/view/213573
• topic: Late-onset neonatal sepsis; Septic shock; Lipoproteins; Monocyte-to-HDL ratio

Background: The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. The aims are to assess lipid profile, cytokines, and Monocyte-to-HDL (M/H) ratio as diagnostic and prognostic markers for late-onset neonatal sepsis. Methods: This prospective study included 49 septic neonates and 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), and High-Density Lipoproteins (HDLc) were measured at admission (D0) and on days 3, 7 and 10 to evaluate septic shock outcomes. Cytokines and monocytes were evaluated by flow cytometry. Results: Septic newborns showed higher IL-6 and IL-8 at D0 and CT levels on D7 and on D10, which also presented higher TG, VLDLc and non-HDL cholesterol concentrations than controls. The septic shock group (n = 22) revealed a higher number of male subjects, CRP, IL-6, IL-8 and IL-10 levels, while lower TG, HDLc, monocyte numbers and M/H ratio at admission compared to the non-shock group (n = 27). M/H ratio and non-HDL cholesterol on D0 were risk factors for septic shock (OR = 0.70, 0.49‒0.99; OR = 0.96, 0.92‒0.99, respectively). Decreasing levels from D0 to D3 of CT (OR = 0.96, 0.93‒0.99), VLDLc (OR = 0.91, 0.85‒0.98), and non-HDL cholesterol (OR = 0.92, 0.87‒0.98) were also predictors of septic shock. Conclusions: Lower M/H ratios and non-HDL cholesterol at admission and decreasing levels of cholesterol, VLDLc and non-HDL cholesterol during a hospital stay are associated with the development of septic shock in newborns with late-onset neonatal sepsis.