Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns

Detalhes bibliográficos
Autor(a) principal: Fonseca, Fernanda Andrade Macaferri da
Data de Publicação: 2022
Outros Autores: Espósito, Aline Paulino, Silva, Maria Helena Baptista Nunes da, Nunes, Valéria Sutti, Cazita, Patricia Miralda, Ferreira, Guilherme Silva, Ceccon, Maria Esther Jurfest Rivero, Carvalho, Werther Brunow de, Carneiro-Sampaio, Magda, Palmeira, Patricia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/213573
Resumo: Background: The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. The aims are to assess lipid profile, cytokines, and Monocyte-to-HDL (M/H) ratio as diagnostic and prognostic markers for late-onset neonatal sepsis. Methods: This prospective study included 49 septic neonates and 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), and High-Density Lipoproteins (HDLc) were measured at admission (D0) and on days 3, 7 and 10 to evaluate septic shock outcomes. Cytokines and monocytes were evaluated by flow cytometry. Results: Septic newborns showed higher IL-6 and IL-8 at D0 and CT levels on D7 and on D10, which also presented higher TG, VLDLc and non-HDL cholesterol concentrations than controls. The septic shock group (n = 22) revealed a higher number of male subjects, CRP, IL-6, IL-8 and IL-10 levels, while lower TG, HDLc, monocyte numbers and M/H ratio at admission compared to the non-shock group (n = 27). M/H ratio and non-HDL cholesterol on D0 were risk factors for septic shock (OR = 0.70, 0.49‒0.99; OR = 0.96, 0.92‒0.99, respectively). Decreasing levels from D0 to D3 of CT (OR = 0.96, 0.93‒0.99), VLDLc (OR = 0.91, 0.85‒0.98), and non-HDL cholesterol (OR = 0.92, 0.87‒0.98) were also predictors of septic shock. Conclusions: Lower M/H ratios and non-HDL cholesterol at admission and decreasing levels of cholesterol, VLDLc and non-HDL cholesterol during a hospital stay are associated with the development of septic shock in newborns with late-onset neonatal sepsis.
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spelling Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newbornsLate-onset neonatal sepsisSeptic shockLipoproteinsMonocyte-to-HDL ratioBackground: The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. The aims are to assess lipid profile, cytokines, and Monocyte-to-HDL (M/H) ratio as diagnostic and prognostic markers for late-onset neonatal sepsis. Methods: This prospective study included 49 septic neonates and 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), and High-Density Lipoproteins (HDLc) were measured at admission (D0) and on days 3, 7 and 10 to evaluate septic shock outcomes. Cytokines and monocytes were evaluated by flow cytometry. Results: Septic newborns showed higher IL-6 and IL-8 at D0 and CT levels on D7 and on D10, which also presented higher TG, VLDLc and non-HDL cholesterol concentrations than controls. The septic shock group (n = 22) revealed a higher number of male subjects, CRP, IL-6, IL-8 and IL-10 levels, while lower TG, HDLc, monocyte numbers and M/H ratio at admission compared to the non-shock group (n = 27). M/H ratio and non-HDL cholesterol on D0 were risk factors for septic shock (OR = 0.70, 0.49‒0.99; OR = 0.96, 0.92‒0.99, respectively). Decreasing levels from D0 to D3 of CT (OR = 0.96, 0.93‒0.99), VLDLc (OR = 0.91, 0.85‒0.98), and non-HDL cholesterol (OR = 0.92, 0.87‒0.98) were also predictors of septic shock. Conclusions: Lower M/H ratios and non-HDL cholesterol at admission and decreasing levels of cholesterol, VLDLc and non-HDL cholesterol during a hospital stay are associated with the development of septic shock in newborns with late-onset neonatal sepsis.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2022-11-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/21357310.1016/j.clinsp.2022.100111Clinics; Vol. 77 (2022); 100111Clinics; v. 77 (2022); 100111Clinics; Vol. 77 (2022); 1001111980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/213573/195650Copyright (c) 2023 Clinicsinfo:eu-repo/semantics/openAccessFonseca, Fernanda Andrade Macaferri daEspósito, Aline PaulinoSilva, Maria Helena Baptista Nunes daNunes, Valéria SuttiCazita, Patricia MiraldaFerreira, Guilherme SilvaCeccon, Maria Esther Jurfest RiveroCarvalho, Werther Brunow deCarneiro-Sampaio, MagdaPalmeira, Patricia2023-07-06T13:04:59Zoai:revistas.usp.br:article/213573Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2023-07-06T13:04:59Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns
title Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns
spellingShingle Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns
Fonseca, Fernanda Andrade Macaferri da
Late-onset neonatal sepsis
Septic shock
Lipoproteins
Monocyte-to-HDL ratio
title_short Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns
title_full Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns
title_fullStr Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns
title_full_unstemmed Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns
title_sort Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns
author Fonseca, Fernanda Andrade Macaferri da
author_facet Fonseca, Fernanda Andrade Macaferri da
Espósito, Aline Paulino
Silva, Maria Helena Baptista Nunes da
Nunes, Valéria Sutti
Cazita, Patricia Miralda
Ferreira, Guilherme Silva
Ceccon, Maria Esther Jurfest Rivero
Carvalho, Werther Brunow de
Carneiro-Sampaio, Magda
Palmeira, Patricia
author_role author
author2 Espósito, Aline Paulino
Silva, Maria Helena Baptista Nunes da
Nunes, Valéria Sutti
Cazita, Patricia Miralda
Ferreira, Guilherme Silva
Ceccon, Maria Esther Jurfest Rivero
Carvalho, Werther Brunow de
Carneiro-Sampaio, Magda
Palmeira, Patricia
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fonseca, Fernanda Andrade Macaferri da
Espósito, Aline Paulino
Silva, Maria Helena Baptista Nunes da
Nunes, Valéria Sutti
Cazita, Patricia Miralda
Ferreira, Guilherme Silva
Ceccon, Maria Esther Jurfest Rivero
Carvalho, Werther Brunow de
Carneiro-Sampaio, Magda
Palmeira, Patricia
dc.subject.por.fl_str_mv Late-onset neonatal sepsis
Septic shock
Lipoproteins
Monocyte-to-HDL ratio
topic Late-onset neonatal sepsis
Septic shock
Lipoproteins
Monocyte-to-HDL ratio
description Background: The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. The aims are to assess lipid profile, cytokines, and Monocyte-to-HDL (M/H) ratio as diagnostic and prognostic markers for late-onset neonatal sepsis. Methods: This prospective study included 49 septic neonates and 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), and High-Density Lipoproteins (HDLc) were measured at admission (D0) and on days 3, 7 and 10 to evaluate septic shock outcomes. Cytokines and monocytes were evaluated by flow cytometry. Results: Septic newborns showed higher IL-6 and IL-8 at D0 and CT levels on D7 and on D10, which also presented higher TG, VLDLc and non-HDL cholesterol concentrations than controls. The septic shock group (n = 22) revealed a higher number of male subjects, CRP, IL-6, IL-8 and IL-10 levels, while lower TG, HDLc, monocyte numbers and M/H ratio at admission compared to the non-shock group (n = 27). M/H ratio and non-HDL cholesterol on D0 were risk factors for septic shock (OR = 0.70, 0.49‒0.99; OR = 0.96, 0.92‒0.99, respectively). Decreasing levels from D0 to D3 of CT (OR = 0.96, 0.93‒0.99), VLDLc (OR = 0.91, 0.85‒0.98), and non-HDL cholesterol (OR = 0.92, 0.87‒0.98) were also predictors of septic shock. Conclusions: Lower M/H ratios and non-HDL cholesterol at admission and decreasing levels of cholesterol, VLDLc and non-HDL cholesterol during a hospital stay are associated with the development of septic shock in newborns with late-onset neonatal sepsis.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/213573
10.1016/j.clinsp.2022.100111
url https://www.revistas.usp.br/clinics/article/view/213573
identifier_str_mv 10.1016/j.clinsp.2022.100111
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/213573/195650
dc.rights.driver.fl_str_mv Copyright (c) 2023 Clinics
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Clinics
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 77 (2022); 100111
Clinics; v. 77 (2022); 100111
Clinics; Vol. 77 (2022); 100111
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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