Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/164113 |
Resumo: | OBJECTIVE: There are no doubts about the clinical benefits of treatment with GnRH analogs for patients diagnosed with central precocious puberty (CPP). However, laboratory monitoring of CPP is still a matter of considerable controversy in the literature. Therefore, the main objective of this study was to evaluate the cut-off values of stimulated LH that determine gonadotrophic suppression. METHODS: Twenty-four girls, on treatment with leuprorelin acetate (LA) at 3.75 mg IM every 28 days, were studied. The clinical parameters used to indicate clinical effectiveness were regression or maintenance of sexual characteristics according to the Tanner stage, growth velocity reduction, reduction or maintenance of the difference between bone age and chronological age and maintenance or improvement of the final height prediction. For the laboratory effectiveness test, basal estradiol, LH, and FSH levels were collected before and 1 and 2 h after the administration of 3.75 mg LA. RESULTS: Eleven girls showed improvement in all clinical parameters, and their effectiveness tests were compared to those of the other patients to calculate the cut-off values, which were p3.64 IU/L (p=0.004*) for LH after 1 h and p6.10 IU/L (po0.001*) for LH after 2 h. CONCLUSION: The LH response after the LA stimulation test, associated with clinical data and within a context of CPP, constitutes a reliable and feasible resource and can assist in monitoring the effectiveness of treatment. |
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Clinics |
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Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious PubertyGonadotropin-Releasing HormonePubertyTherapeuticsLuteinizing HormoneFollicle Stimulating HormoneEstradiolGrowthOBJECTIVE: There are no doubts about the clinical benefits of treatment with GnRH analogs for patients diagnosed with central precocious puberty (CPP). However, laboratory monitoring of CPP is still a matter of considerable controversy in the literature. Therefore, the main objective of this study was to evaluate the cut-off values of stimulated LH that determine gonadotrophic suppression. METHODS: Twenty-four girls, on treatment with leuprorelin acetate (LA) at 3.75 mg IM every 28 days, were studied. The clinical parameters used to indicate clinical effectiveness were regression or maintenance of sexual characteristics according to the Tanner stage, growth velocity reduction, reduction or maintenance of the difference between bone age and chronological age and maintenance or improvement of the final height prediction. For the laboratory effectiveness test, basal estradiol, LH, and FSH levels were collected before and 1 and 2 h after the administration of 3.75 mg LA. RESULTS: Eleven girls showed improvement in all clinical parameters, and their effectiveness tests were compared to those of the other patients to calculate the cut-off values, which were p3.64 IU/L (p=0.004*) for LH after 1 h and p6.10 IU/L (po0.001*) for LH after 2 h. CONCLUSION: The LH response after the LA stimulation test, associated with clinical data and within a context of CPP, constitutes a reliable and feasible resource and can assist in monitoring the effectiveness of treatment.Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2019-11-14info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/clinics/article/view/16411310.6061/clinics/2019/e1205Clinics; Vol. 74 (2019); e1205Clinics; v. 74 (2019); e1205Clinics; Vol. 74 (2019); e12051980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/164113/157549https://www.revistas.usp.br/clinics/article/view/164113/157550Copyright (c) 2019 Clinicsinfo:eu-repo/semantics/openAccessFujita, Lívia Grimaldi AbudPalhares, Heloísa Marcelina da CunhaSilva, Adriana Paula daTomé, Janaíne MachadoBorges, Maria de Fátima2019-11-14T18:43:10Zoai:revistas.usp.br:article/164113Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2019-11-14T18:43:10Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty |
title |
Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty |
spellingShingle |
Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty Fujita, Lívia Grimaldi Abud Gonadotropin-Releasing Hormone Puberty Therapeutics Luteinizing Hormone Follicle Stimulating Hormone Estradiol Growth |
title_short |
Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty |
title_full |
Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty |
title_fullStr |
Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty |
title_full_unstemmed |
Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty |
title_sort |
Clinical and Laboratory Parameters of GonadotropinReleasing Hormone Analog Treatment Effectiveness in Children with Precocious Puberty |
author |
Fujita, Lívia Grimaldi Abud |
author_facet |
Fujita, Lívia Grimaldi Abud Palhares, Heloísa Marcelina da Cunha Silva, Adriana Paula da Tomé, Janaíne Machado Borges, Maria de Fátima |
author_role |
author |
author2 |
Palhares, Heloísa Marcelina da Cunha Silva, Adriana Paula da Tomé, Janaíne Machado Borges, Maria de Fátima |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Fujita, Lívia Grimaldi Abud Palhares, Heloísa Marcelina da Cunha Silva, Adriana Paula da Tomé, Janaíne Machado Borges, Maria de Fátima |
dc.subject.por.fl_str_mv |
Gonadotropin-Releasing Hormone Puberty Therapeutics Luteinizing Hormone Follicle Stimulating Hormone Estradiol Growth |
topic |
Gonadotropin-Releasing Hormone Puberty Therapeutics Luteinizing Hormone Follicle Stimulating Hormone Estradiol Growth |
description |
OBJECTIVE: There are no doubts about the clinical benefits of treatment with GnRH analogs for patients diagnosed with central precocious puberty (CPP). However, laboratory monitoring of CPP is still a matter of considerable controversy in the literature. Therefore, the main objective of this study was to evaluate the cut-off values of stimulated LH that determine gonadotrophic suppression. METHODS: Twenty-four girls, on treatment with leuprorelin acetate (LA) at 3.75 mg IM every 28 days, were studied. The clinical parameters used to indicate clinical effectiveness were regression or maintenance of sexual characteristics according to the Tanner stage, growth velocity reduction, reduction or maintenance of the difference between bone age and chronological age and maintenance or improvement of the final height prediction. For the laboratory effectiveness test, basal estradiol, LH, and FSH levels were collected before and 1 and 2 h after the administration of 3.75 mg LA. RESULTS: Eleven girls showed improvement in all clinical parameters, and their effectiveness tests were compared to those of the other patients to calculate the cut-off values, which were p3.64 IU/L (p=0.004*) for LH after 1 h and p6.10 IU/L (po0.001*) for LH after 2 h. CONCLUSION: The LH response after the LA stimulation test, associated with clinical data and within a context of CPP, constitutes a reliable and feasible resource and can assist in monitoring the effectiveness of treatment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-14 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/164113 10.6061/clinics/2019/e1205 |
url |
https://www.revistas.usp.br/clinics/article/view/164113 |
identifier_str_mv |
10.6061/clinics/2019/e1205 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/164113/157549 https://www.revistas.usp.br/clinics/article/view/164113/157550 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Clinics info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Clinics |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 74 (2019); e1205 Clinics; v. 74 (2019); e1205 Clinics; Vol. 74 (2019); e1205 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222764648366080 |