An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study

Detalhes bibliográficos
Autor(a) principal: Kayiran, Sinan Mahir
Data de Publicação: 2010
Outros Autores: Dindar, Aygün, Gurakan, Berkan
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/18457
Resumo: BACKGROUND: Kawasaki disease (KD) is an acute, self-limiting vasculitis of unknown etiology. The incidence of KD is increasing world wide. However, the epidemiological data for KD in Turkey has not been well described. OBJECTIVE: To describe the demographic, clinical, and laboratory features of children with KD who were diagnosed and managed in the American Hospital, Istanbul, Turkey. METHOD: Patients with KD were retrospectively identified from the hospital discharge records between 2002 and 2010. Atypical cases of KD were excluded. A standardized form was used to collect demographic data, clinical information, echocardiography and laboratory results. RESULTS: Thirty-five patients with KD, with a mean age of 2.5 + 1.9 years, were identified. Eighty-five point seven per cent of patients were under 5 years of age. A seasonal pattern favouring the winter months was noticed. In addition to fever and bilateral conjunctival injection, changes in the oral cavity and lips were the most commonly detected clinical signs in our cases. Coronary artery abnormalities were detected in nine patients. The majority of our patients had started treatment with intravenous immunoglobulin in the first 10 days of the onset of fever, and only one patient required systemic steroids for intravenous immunoglobulin-resistant KD. The coronary artery abnormalities resolved in all nine patients within 8 months. CONCLUSION: This study is the most comprehensive series of children from Turkey with KD included in Medline. As adult-onset ischemic heart disease may be due to KD in childhood, further prospective clinical investigations are needed to understand the epidemiology, management and long-term follow-up of the disease.
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spelling An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study Kawasaki diseaseCoronary artery diseaseEchocardiographySteroids BACKGROUND: Kawasaki disease (KD) is an acute, self-limiting vasculitis of unknown etiology. The incidence of KD is increasing world wide. However, the epidemiological data for KD in Turkey has not been well described. OBJECTIVE: To describe the demographic, clinical, and laboratory features of children with KD who were diagnosed and managed in the American Hospital, Istanbul, Turkey. METHOD: Patients with KD were retrospectively identified from the hospital discharge records between 2002 and 2010. Atypical cases of KD were excluded. A standardized form was used to collect demographic data, clinical information, echocardiography and laboratory results. RESULTS: Thirty-five patients with KD, with a mean age of 2.5 + 1.9 years, were identified. Eighty-five point seven per cent of patients were under 5 years of age. A seasonal pattern favouring the winter months was noticed. In addition to fever and bilateral conjunctival injection, changes in the oral cavity and lips were the most commonly detected clinical signs in our cases. Coronary artery abnormalities were detected in nine patients. The majority of our patients had started treatment with intravenous immunoglobulin in the first 10 days of the onset of fever, and only one patient required systemic steroids for intravenous immunoglobulin-resistant KD. The coronary artery abnormalities resolved in all nine patients within 8 months. CONCLUSION: This study is the most comprehensive series of children from Turkey with KD included in Medline. As adult-onset ischemic heart disease may be due to KD in childhood, further prospective clinical investigations are needed to understand the epidemiology, management and long-term follow-up of the disease. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1845710.1590/S1807-59322010001200007Clinics; Vol. 65 No. 12 (2010); 1261-1265 Clinics; v. 65 n. 12 (2010); 1261-1265 Clinics; Vol. 65 Núm. 12 (2010); 1261-1265 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/18457/20520Kayiran, Sinan MahirDindar, AygünGurakan, Berkaninfo:eu-repo/semantics/openAccess2012-05-23T11:25:17Zoai:revistas.usp.br:article/18457Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T11:25:17Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study
title An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study
spellingShingle An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study
Kayiran, Sinan Mahir
Kawasaki disease
Coronary artery disease
Echocardiography
Steroids
title_short An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study
title_full An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study
title_fullStr An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study
title_full_unstemmed An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study
title_sort An evaluation of children with Kawasaki disease in Istanbul: a retrospective follow-up study
author Kayiran, Sinan Mahir
author_facet Kayiran, Sinan Mahir
Dindar, Aygün
Gurakan, Berkan
author_role author
author2 Dindar, Aygün
Gurakan, Berkan
author2_role author
author
dc.contributor.author.fl_str_mv Kayiran, Sinan Mahir
Dindar, Aygün
Gurakan, Berkan
dc.subject.por.fl_str_mv Kawasaki disease
Coronary artery disease
Echocardiography
Steroids
topic Kawasaki disease
Coronary artery disease
Echocardiography
Steroids
description BACKGROUND: Kawasaki disease (KD) is an acute, self-limiting vasculitis of unknown etiology. The incidence of KD is increasing world wide. However, the epidemiological data for KD in Turkey has not been well described. OBJECTIVE: To describe the demographic, clinical, and laboratory features of children with KD who were diagnosed and managed in the American Hospital, Istanbul, Turkey. METHOD: Patients with KD were retrospectively identified from the hospital discharge records between 2002 and 2010. Atypical cases of KD were excluded. A standardized form was used to collect demographic data, clinical information, echocardiography and laboratory results. RESULTS: Thirty-five patients with KD, with a mean age of 2.5 + 1.9 years, were identified. Eighty-five point seven per cent of patients were under 5 years of age. A seasonal pattern favouring the winter months was noticed. In addition to fever and bilateral conjunctival injection, changes in the oral cavity and lips were the most commonly detected clinical signs in our cases. Coronary artery abnormalities were detected in nine patients. The majority of our patients had started treatment with intravenous immunoglobulin in the first 10 days of the onset of fever, and only one patient required systemic steroids for intravenous immunoglobulin-resistant KD. The coronary artery abnormalities resolved in all nine patients within 8 months. CONCLUSION: This study is the most comprehensive series of children from Turkey with KD included in Medline. As adult-onset ischemic heart disease may be due to KD in childhood, further prospective clinical investigations are needed to understand the epidemiology, management and long-term follow-up of the disease.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18457
10.1590/S1807-59322010001200007
url https://www.revistas.usp.br/clinics/article/view/18457
identifier_str_mv 10.1590/S1807-59322010001200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/18457/20520
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 65 No. 12 (2010); 1261-1265
Clinics; v. 65 n. 12 (2010); 1261-1265
Clinics; Vol. 65 Núm. 12 (2010); 1261-1265
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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