Resistant tuberculosis: a molecular review

Detalhes bibliográficos
Autor(a) principal: Rossetti, Maria Lúcia Rosa
Data de Publicação: 2002
Outros Autores: Valim, Andréia Rosane de Moura, Silva, Márcia Susana Nunes, Rodrigues, Vívian Sumnienski
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/31545
Resumo: Progress to understanding the basis of resistance to antituberculous drugs has allowed molecular tests for detection of drug-resistant tuberculosis to be developed. Drug-resistant tuberculosis poses a threat to tuberculosis control programs. It is necessary thus to know drug susceptibilities of individual patient's strain to provide the appropriate drug combinations. Molecular studies on the mechanism of action of antituberculous drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. The mechanisms of drug resistance in tuberculosis are a result of chromosomal mutations in different genes of the bacteria. Upon drug exposure there is a selective pressure for such resistant mutants. Multidrug-resistant tuberculosis is a health problem of increasing significance for the whole global community. This paper reviews the molecular mechanisms associated with drug-resistance as well the new perspectives for detecting resistant isolates.
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spelling Resistant tuberculosis: a molecular review Tuberculose resistente: revisão molecular Tuberculosis^i2^sprevention & contTuberculosis^i2^sdrug therAntitubercular agents^i2^spharmacokinetTuberculosismultidrug-resistantMycobacterium tuberculosis^i2^sdrug effeDrug resistancemultipleIsoniazid^i2^spharmacokinetRifampin^i2^spharmacokinetPyrazinamide^i2^spharmacokinetEthambutol^i2^spharmacokinetStreptomycin^i2^spharmacokinetTuberculose^i1^sprevenTuberculose^i1^squimioteraAntituberculosos^i1^sfarmacocinétTuberculose resistente a múltiplas drogasMycobacterium tuberculosis^i1^sefeito droResistência a múltiplas drogasIsoniazida^i1^sfarmacocinétRifampina^i1^sfarmacocinétPirazinamida^i1^sfarmacocinétEtambutol^i1^sfarmacocinétEstreptomicina^i1^sfarmacocinét Progress to understanding the basis of resistance to antituberculous drugs has allowed molecular tests for detection of drug-resistant tuberculosis to be developed. Drug-resistant tuberculosis poses a threat to tuberculosis control programs. It is necessary thus to know drug susceptibilities of individual patient's strain to provide the appropriate drug combinations. Molecular studies on the mechanism of action of antituberculous drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. The mechanisms of drug resistance in tuberculosis are a result of chromosomal mutations in different genes of the bacteria. Upon drug exposure there is a selective pressure for such resistant mutants. Multidrug-resistant tuberculosis is a health problem of increasing significance for the whole global community. This paper reviews the molecular mechanisms associated with drug-resistance as well the new perspectives for detecting resistant isolates. O progresso na compreensão dos mecanismos de resistência aos fármacos usados no tratamento da tuberculose tem permitido o desenvolvimento de novos métodos para a detecção da tuberculose resistente. A resistente aos fármacos representa uma ameaça para os programas de controle da tuberculose. Para tanto, é necessário conhecer o padrão de sensibilidade das linhagens para fornecer o tratamento adequado. Os estudos moleculares dos mecanismos de ação dos fármacos antituberculose têm elucidado as bases genéticas da resistência aos fármacos em Mycobacterium tuberculosis. Os mecanismos de resistência aos fármacos na tuberculose são causados por mutações cromossomais em diferentes genes da bactéria. Durante a exposição aos fármacos, há uma pressão seletiva favorecendo o desenvolvimento de linhagens resistentes. A tuberculose multirresistente é um problema nacional e internacional que traz sérias dificuldades para o controle global da doença. Realizou-se uma revisão sobre os mecanismos moleculares associados à resistência aos fármacos com ênfase nas novas perspectivas para detectar os isolados resistentes. Universidade de São Paulo. Faculdade de Saúde Pública2002-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/.pdfhttps://www.revistas.usp.br/rsp/article/view/3154510.1590/S0034-89102002000400021Revista de Saúde Pública; Vol. 36 No. 4 (2002); 525-532 Revista de Saúde Pública; Vol. 36 Núm. 4 (2002); 525-532 Revista de Saúde Pública; v. 36 n. 4 (2002); 525-532 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/31545/33430Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessRossetti, Maria Lúcia RosaValim, Andréia Rosane de MouraSilva, Márcia Susana NunesRodrigues, Vívian Sumnienski2012-07-08T14:39:34Zoai:revistas.usp.br:article/31545Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-07-08T14:39:34Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Resistant tuberculosis: a molecular review
Tuberculose resistente: revisão molecular
title Resistant tuberculosis: a molecular review
spellingShingle Resistant tuberculosis: a molecular review
Rossetti, Maria Lúcia Rosa
Tuberculosis^i2^sprevention & cont
Tuberculosis^i2^sdrug ther
Antitubercular agents^i2^spharmacokinet
Tuberculosis
multidrug-resistant
Mycobacterium tuberculosis^i2^sdrug effe
Drug resistance
multiple
Isoniazid^i2^spharmacokinet
Rifampin^i2^spharmacokinet
Pyrazinamide^i2^spharmacokinet
Ethambutol^i2^spharmacokinet
Streptomycin^i2^spharmacokinet
Tuberculose^i1^spreven
Tuberculose^i1^squimiotera
Antituberculosos^i1^sfarmacocinét
Tuberculose resistente a múltiplas drogas
Mycobacterium tuberculosis^i1^sefeito dro
Resistência a múltiplas drogas
Isoniazida^i1^sfarmacocinét
Rifampina^i1^sfarmacocinét
Pirazinamida^i1^sfarmacocinét
Etambutol^i1^sfarmacocinét
Estreptomicina^i1^sfarmacocinét
title_short Resistant tuberculosis: a molecular review
title_full Resistant tuberculosis: a molecular review
title_fullStr Resistant tuberculosis: a molecular review
title_full_unstemmed Resistant tuberculosis: a molecular review
title_sort Resistant tuberculosis: a molecular review
author Rossetti, Maria Lúcia Rosa
author_facet Rossetti, Maria Lúcia Rosa
Valim, Andréia Rosane de Moura
Silva, Márcia Susana Nunes
Rodrigues, Vívian Sumnienski
author_role author
author2 Valim, Andréia Rosane de Moura
Silva, Márcia Susana Nunes
Rodrigues, Vívian Sumnienski
author2_role author
author
author
dc.contributor.author.fl_str_mv Rossetti, Maria Lúcia Rosa
Valim, Andréia Rosane de Moura
Silva, Márcia Susana Nunes
Rodrigues, Vívian Sumnienski
dc.subject.por.fl_str_mv Tuberculosis^i2^sprevention & cont
Tuberculosis^i2^sdrug ther
Antitubercular agents^i2^spharmacokinet
Tuberculosis
multidrug-resistant
Mycobacterium tuberculosis^i2^sdrug effe
Drug resistance
multiple
Isoniazid^i2^spharmacokinet
Rifampin^i2^spharmacokinet
Pyrazinamide^i2^spharmacokinet
Ethambutol^i2^spharmacokinet
Streptomycin^i2^spharmacokinet
Tuberculose^i1^spreven
Tuberculose^i1^squimiotera
Antituberculosos^i1^sfarmacocinét
Tuberculose resistente a múltiplas drogas
Mycobacterium tuberculosis^i1^sefeito dro
Resistência a múltiplas drogas
Isoniazida^i1^sfarmacocinét
Rifampina^i1^sfarmacocinét
Pirazinamida^i1^sfarmacocinét
Etambutol^i1^sfarmacocinét
Estreptomicina^i1^sfarmacocinét
topic Tuberculosis^i2^sprevention & cont
Tuberculosis^i2^sdrug ther
Antitubercular agents^i2^spharmacokinet
Tuberculosis
multidrug-resistant
Mycobacterium tuberculosis^i2^sdrug effe
Drug resistance
multiple
Isoniazid^i2^spharmacokinet
Rifampin^i2^spharmacokinet
Pyrazinamide^i2^spharmacokinet
Ethambutol^i2^spharmacokinet
Streptomycin^i2^spharmacokinet
Tuberculose^i1^spreven
Tuberculose^i1^squimiotera
Antituberculosos^i1^sfarmacocinét
Tuberculose resistente a múltiplas drogas
Mycobacterium tuberculosis^i1^sefeito dro
Resistência a múltiplas drogas
Isoniazida^i1^sfarmacocinét
Rifampina^i1^sfarmacocinét
Pirazinamida^i1^sfarmacocinét
Etambutol^i1^sfarmacocinét
Estreptomicina^i1^sfarmacocinét
description Progress to understanding the basis of resistance to antituberculous drugs has allowed molecular tests for detection of drug-resistant tuberculosis to be developed. Drug-resistant tuberculosis poses a threat to tuberculosis control programs. It is necessary thus to know drug susceptibilities of individual patient's strain to provide the appropriate drug combinations. Molecular studies on the mechanism of action of antituberculous drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. The mechanisms of drug resistance in tuberculosis are a result of chromosomal mutations in different genes of the bacteria. Upon drug exposure there is a selective pressure for such resistant mutants. Multidrug-resistant tuberculosis is a health problem of increasing significance for the whole global community. This paper reviews the molecular mechanisms associated with drug-resistance as well the new perspectives for detecting resistant isolates.
publishDate 2002
dc.date.none.fl_str_mv 2002-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/31545
10.1590/S0034-89102002000400021
url https://www.revistas.usp.br/rsp/article/view/31545
identifier_str_mv 10.1590/S0034-89102002000400021
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/31545/33430
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/.pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 36 No. 4 (2002); 525-532
Revista de Saúde Pública; Vol. 36 Núm. 4 (2002); 525-532
Revista de Saúde Pública; v. 36 n. 4 (2002); 525-532
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
_version_ 1800221766497337344

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