Determinants of salivary cotinine level: a population-based study in Brazil

• Autor(a) principal: Figueiredo, Valeska Carvalho
• Data de Publicação: 2007
• Outros Autores: Szklo, Moyses, Szklo, André Salem, Benowitz, Neal, Lozana, José Azevedo, Casado, Leticia, Masson, Elaine, Samet, Jonathan
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista de Saúde Pública
• Texto Completo: https://www.revistas.usp.br/rsp/article/view/32336
• topic: Smoking; Cotinine^i1^spharmacokinet; Cross-sectional studies; Tabagismo; Cotinina^i2^sfarmacocinét; Estudos transversais

OBJECTIVE: A cross-sectional population-based study was conducted to assess, in active smokers, the relationship of number of cigarettes smoked and other characteristics to salivary cotinine concentrations. METHODS: A random sample of active smokers aged 15 years or older was selected using a stepwise cluster sample strategy, in the year 2000 in Rio de Janeiro, Brazil. The study included 401 subjects. Salivary cotinine concentration was determined using gas chromatography with nitrogen-phosphorus detection. A standard questionnaire was used to collect demographic and smoking behavioral data. The relation between the number of cigarettes smoked in the last 24h and cotinine level was examined by means of a nonparametric fitting technique of robust locally weighted regression. RESULTS: Significantly (p;40 ng/mL per cigarette were excluded. CONCLUSIONS: There was found a positive association between self-reporting smoking five minutes after waking up, and inhaling more than ½ the time are consistent and higher cotinine levels. These can be markers of dependence and higher nicotine intake. Salivary cotinine proved to be a useful biomarker of recent smoking and can be used in epidemiological studies and smoking cessation programs.