Hospital readmissions related to drug interactions: a retrospective study in a hospital setting

Detalhes bibliográficos
Autor(a) principal: Moura, Cristiano Soares de
Data de Publicação: 2012
Outros Autores: Tavares, Ludmila Santana, Acurcio, Francisco de Assis
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/53463
Resumo: OBJECTIVE: To examine the relationship between potential drug interactions and hospital readmissions. METHODS: Retrospective study with 1,487 adult patients (&gt; 18 years old) admitted to a general hospital in the city of Vitória da Conquista, Northeastern Brazil, from January to December 2007. Data were collected from Hospital Admission Authorization (AIH) forms in the Brazilian National Health System Hospital Database (SIH/SUS). Probabilistic linkage was used to combine multiple AIH forms from the same admission into a single record and to identify readmissions. Information on prescriptions was manually added to the SIH/SUS records. Logistic regression was used to quantitatively assess the impact of drug interactions on hospital readmissions. Cox regression was performed to test the impact of this variable on time to first readmission. RESULTS: A total of 99 readmissions (7% of all patients) were identified. Potential drug interactions were found in 35% of all prescriptions evaluated. Patients with potential drug interactions in a prior admission were more likely to be readmitted. The adjusted odds ratio indicated a 2.4-fold increase in odds of being readmitted; and the adjusted hazard ratio showed that this risk was increased by 79% in patients with potential drug interactions (p < 0.01). CONCLUSIONS: The study results suggest an association between prior drug interactions and increased risk of readmission. Health professionals should be aware of potential hazard of certain drug combinations and closely monitor high-risk patients such as elderly patients and those with renal impairment.
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spelling Hospital readmissions related to drug interactions: a retrospective study in a hospital setting Interacción medicamentosa asociada a la reinternación hospitalaria: estudio retrospectivo en un hospital general Interação medicamentosa associada à reinternação hospitalar: estudo retrospectivo em um hospital geral Readmissão do PacienteInterações de MedicamentosHospitalizaçãoEfeitos adversosPolimedicaçãoReadmisión del PacienteInteracciones de DrogasHospitalizaciónEfectos adversosPolifarmaciaPatient ReadmissionDrug InteractionsHospitalizationAdverse effectsPolypharmacy OBJECTIVE: To examine the relationship between potential drug interactions and hospital readmissions. METHODS: Retrospective study with 1,487 adult patients (&gt; 18 years old) admitted to a general hospital in the city of Vitória da Conquista, Northeastern Brazil, from January to December 2007. Data were collected from Hospital Admission Authorization (AIH) forms in the Brazilian National Health System Hospital Database (SIH/SUS). Probabilistic linkage was used to combine multiple AIH forms from the same admission into a single record and to identify readmissions. Information on prescriptions was manually added to the SIH/SUS records. Logistic regression was used to quantitatively assess the impact of drug interactions on hospital readmissions. Cox regression was performed to test the impact of this variable on time to first readmission. RESULTS: A total of 99 readmissions (7% of all patients) were identified. Potential drug interactions were found in 35% of all prescriptions evaluated. Patients with potential drug interactions in a prior admission were more likely to be readmitted. The adjusted odds ratio indicated a 2.4-fold increase in odds of being readmitted; and the adjusted hazard ratio showed that this risk was increased by 79% in patients with potential drug interactions (p < 0.01). CONCLUSIONS: The study results suggest an association between prior drug interactions and increased risk of readmission. Health professionals should be aware of potential hazard of certain drug combinations and closely monitor high-risk patients such as elderly patients and those with renal impairment. OBJETIVO: Analizar la relación entre potencial interacción medicamentosa potencial y reinternación hospitalaria. MÉTODOS: Estudio retrospectivo con 1.487 pacientes mayores de 18 años admitidos en un hospital general en Vitória da Conquista, BA, Brasil, de enero a diciembre de 2007. Los datos fueron extraídos de la Autorización de Internación Hospitalaria del Sistema de Información Hospitalaria del Sistema Único de Salud Brasileño. La relación probabilística fue empleada para combinar múltiples autorizaciones de una misma internación en un único registro y para identificar readmisiones. Información sobre prescripciones fueron agregadas manualmente a los registros del Sistema de Información Hospitalario. La regresión logística fue utilizada para cuantificar la influencia de potencial interacción medicamentosa y reinternación. La regresión de Cox fue empleada para evaluar la influencia de la variable en tiempo hasta la primera reinternación. RESULTADOS: Se identificaron 99 readmisiones (7% de los pacientes). Potencial interacción medicamentosa fue encontrada en 35% de las prescripciones analizadas. Pacientes con potencial de interacción medicamentosa en la admisión previa fueron más propensos a la reinternación. La tasa de chance ajustada indicó que los pacientes tenían chance 2,4 veces mayor de readmisión; la tasa de riesgo ajustada mostró que en pacientes con interacción medicamentosa el riesgo fue 79% mayor (p OBJETIVO: Analisar a relação entre interação medicamentosa potencial e reinternação hospitalar. MÉTODOS: Estudo retrospectivo com 1.487 pacientes maiores de 18 anos admitidos em um hospital geral em Vitória da Conquista, BA, de janeiro a dezembro de 2007. Os dados foram extraídos da Autorização de Internação Hospitalar do Sistema de Informação Hospitalar do Sistema Único de Saúde. O relacionamento probabilístico foi empregado para combinar múltiplas autorizações de uma mesma internação em um único registro e para identificar readmissões. Informações sobre prescrições foram agregadas manualmente aos registros do Sistema de Informação Hospitalar. Regressão logística foi utilizada para quantificar a influência de interação medicamentosa potencial e reinternação. Regressão de Cox foi empregada para testar a influência dessa variável no tempo até a primeira reinternação. RESULTADOS: Foram identificadas 99 readmissões (7% dos pacientes). Interação medicamentosa potencial foi encontrada em 35% das prescrições analisadas. Pacientes com potencial de interação medicamentosa na admissão prévia foram mais propensos à reinternação. A razão de chance ajustada indicou que esses pacientes tinham chance 2,4 vezes maior de readmissão; a taxa de risco ajustada mostrou que em pacientes com interação medicamentosa esse risco foi 79% maior (p < 0,01). CONCLUSÕES: Os resultados encontrados neste trabalho sugerem associação entre exposição à interação em internação prévia e risco aumentado de reinternação. Os profissionais de saúde devem atentar para os riscos potenciais de certas combinações medicamentosas e monitorar cuidadosamente pacientes em maior risco, como aqueles com insuficiência renal ou idosos. Universidade de São Paulo. Faculdade de Saúde Pública2012-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/5346310.1590/S0034-89102013005000001Revista de Saúde Pública; Vol. 46 No. 6 (2012); 1082-1089 Revista de Saúde Pública; Vol. 46 Núm. 6 (2012); 1082-1089 Revista de Saúde Pública; v. 46 n. 6 (2012); 1082-1089 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/53463/57438Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessMoura, Cristiano Soares deTavares, Ludmila SantanaAcurcio, Francisco de Assis2013-04-12T20:22:35Zoai:revistas.usp.br:article/53463Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2013-04-12T20:22:35Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Hospital readmissions related to drug interactions: a retrospective study in a hospital setting
Interacción medicamentosa asociada a la reinternación hospitalaria: estudio retrospectivo en un hospital general
Interação medicamentosa associada à reinternação hospitalar: estudo retrospectivo em um hospital geral
title Hospital readmissions related to drug interactions: a retrospective study in a hospital setting
spellingShingle Hospital readmissions related to drug interactions: a retrospective study in a hospital setting
Moura, Cristiano Soares de
Readmissão do Paciente
Interações de Medicamentos
Hospitalização
Efeitos adversos
Polimedicação
Readmisión del Paciente
Interacciones de Drogas
Hospitalización
Efectos adversos
Polifarmacia
Patient Readmission
Drug Interactions
Hospitalization
Adverse effects
Polypharmacy
title_short Hospital readmissions related to drug interactions: a retrospective study in a hospital setting
title_full Hospital readmissions related to drug interactions: a retrospective study in a hospital setting
title_fullStr Hospital readmissions related to drug interactions: a retrospective study in a hospital setting
title_full_unstemmed Hospital readmissions related to drug interactions: a retrospective study in a hospital setting
title_sort Hospital readmissions related to drug interactions: a retrospective study in a hospital setting
author Moura, Cristiano Soares de
author_facet Moura, Cristiano Soares de
Tavares, Ludmila Santana
Acurcio, Francisco de Assis
author_role author
author2 Tavares, Ludmila Santana
Acurcio, Francisco de Assis
author2_role author
author
dc.contributor.author.fl_str_mv Moura, Cristiano Soares de
Tavares, Ludmila Santana
Acurcio, Francisco de Assis
dc.subject.por.fl_str_mv Readmissão do Paciente
Interações de Medicamentos
Hospitalização
Efeitos adversos
Polimedicação
Readmisión del Paciente
Interacciones de Drogas
Hospitalización
Efectos adversos
Polifarmacia
Patient Readmission
Drug Interactions
Hospitalization
Adverse effects
Polypharmacy
topic Readmissão do Paciente
Interações de Medicamentos
Hospitalização
Efeitos adversos
Polimedicação
Readmisión del Paciente
Interacciones de Drogas
Hospitalización
Efectos adversos
Polifarmacia
Patient Readmission
Drug Interactions
Hospitalization
Adverse effects
Polypharmacy
description OBJECTIVE: To examine the relationship between potential drug interactions and hospital readmissions. METHODS: Retrospective study with 1,487 adult patients (&gt; 18 years old) admitted to a general hospital in the city of Vitória da Conquista, Northeastern Brazil, from January to December 2007. Data were collected from Hospital Admission Authorization (AIH) forms in the Brazilian National Health System Hospital Database (SIH/SUS). Probabilistic linkage was used to combine multiple AIH forms from the same admission into a single record and to identify readmissions. Information on prescriptions was manually added to the SIH/SUS records. Logistic regression was used to quantitatively assess the impact of drug interactions on hospital readmissions. Cox regression was performed to test the impact of this variable on time to first readmission. RESULTS: A total of 99 readmissions (7% of all patients) were identified. Potential drug interactions were found in 35% of all prescriptions evaluated. Patients with potential drug interactions in a prior admission were more likely to be readmitted. The adjusted odds ratio indicated a 2.4-fold increase in odds of being readmitted; and the adjusted hazard ratio showed that this risk was increased by 79% in patients with potential drug interactions (p < 0.01). CONCLUSIONS: The study results suggest an association between prior drug interactions and increased risk of readmission. Health professionals should be aware of potential hazard of certain drug combinations and closely monitor high-risk patients such as elderly patients and those with renal impairment.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/53463
10.1590/S0034-89102013005000001
url https://www.revistas.usp.br/rsp/article/view/53463
identifier_str_mv 10.1590/S0034-89102013005000001
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/53463/57438
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 46 No. 6 (2012); 1082-1089
Revista de Saúde Pública; Vol. 46 Núm. 6 (2012); 1082-1089
Revista de Saúde Pública; v. 46 n. 6 (2012); 1082-1089
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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