Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/222474 |
Resumo: | OBJECTIVES: To evaluate the performance of geneXpert MTB/Rif versus conventional methods (bacilloscopy and culture) in the diagnosis of tuberculosis in a Central Public Health Laboratory (LACEN, Tocantins), Northern Brazil. METHODS: Retrospective study, with information from 1,973 suspected cases of tuberculosis from patients treated from January 2015 to December 2020. RESULTS: From the culture (reference standard), the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the geneXpert MTB/Rif were 100%, 97%, 74%, 100%, and 97%, respectively, against 85%, 98%, 80%, 98%, and 97% of bacilloscopy. CONCLUSIONS: The geneXpert MTB/Rif performed similarly to culture and better than bacilloscopy. Although positive cases with negative culture should be evaluated with caution, its routine use is important for the early detection of tuberculosis. |
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Revista de Saúde Pública |
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Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratoryTuberculosisMycobacterium TuberculosisClinical Laboratory TechniquesOBJECTIVES: To evaluate the performance of geneXpert MTB/Rif versus conventional methods (bacilloscopy and culture) in the diagnosis of tuberculosis in a Central Public Health Laboratory (LACEN, Tocantins), Northern Brazil. METHODS: Retrospective study, with information from 1,973 suspected cases of tuberculosis from patients treated from January 2015 to December 2020. RESULTS: From the culture (reference standard), the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the geneXpert MTB/Rif were 100%, 97%, 74%, 100%, and 97%, respectively, against 85%, 98%, 80%, 98%, and 97% of bacilloscopy. CONCLUSIONS: The geneXpert MTB/Rif performed similarly to culture and better than bacilloscopy. Although positive cases with negative culture should be evaluated with caution, its routine use is important for the early detection of tuberculosis.Universidade de São Paulo. Faculdade de Saúde Pública2024-02-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/xmlapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/22247410.11606/s1518-8787.2024058005306Revista de Saúde Pública; v. 58 n. 1 (2024); 3Revista de Saúde Pública; Vol. 58 Núm. 1 (2024); 3Revista de Saúde Pública; Vol. 58 No. 1 (2024); 31518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/rsp/article/view/222474/203061https://www.revistas.usp.br/rsp/article/view/222474/203062Copyright (c) 2024 Mohanna Damasceno Arbués, Maria Lúcia Rosa Rossettihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessArbués, Mohanna DamascenoRossetti, Maria Lúcia RosaArbués, Mohanna DamascenoRossetti, Maria Lúcia RosaArbués, Mohanna DamascenoRossetti, Maria Lúcia Rosa2024-03-29T08:24:28Zoai:revistas.usp.br:article/222474Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2024-03-29T08:24:28Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory |
title |
Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory |
spellingShingle |
Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory Arbués, Mohanna Damasceno Tuberculosis Mycobacterium Tuberculosis Clinical Laboratory Techniques |
title_short |
Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory |
title_full |
Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory |
title_fullStr |
Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory |
title_full_unstemmed |
Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory |
title_sort |
Evaluation of the GeneXpert MTB/RIF to diagnose tuberculosis in a public health laboratory |
author |
Arbués, Mohanna Damasceno |
author_facet |
Arbués, Mohanna Damasceno Rossetti, Maria Lúcia Rosa |
author_role |
author |
author2 |
Rossetti, Maria Lúcia Rosa |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Arbués, Mohanna Damasceno Rossetti, Maria Lúcia Rosa Arbués, Mohanna Damasceno Rossetti, Maria Lúcia Rosa Arbués, Mohanna Damasceno Rossetti, Maria Lúcia Rosa |
dc.subject.por.fl_str_mv |
Tuberculosis Mycobacterium Tuberculosis Clinical Laboratory Techniques |
topic |
Tuberculosis Mycobacterium Tuberculosis Clinical Laboratory Techniques |
description |
OBJECTIVES: To evaluate the performance of geneXpert MTB/Rif versus conventional methods (bacilloscopy and culture) in the diagnosis of tuberculosis in a Central Public Health Laboratory (LACEN, Tocantins), Northern Brazil. METHODS: Retrospective study, with information from 1,973 suspected cases of tuberculosis from patients treated from January 2015 to December 2020. RESULTS: From the culture (reference standard), the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the geneXpert MTB/Rif were 100%, 97%, 74%, 100%, and 97%, respectively, against 85%, 98%, 80%, 98%, and 97% of bacilloscopy. CONCLUSIONS: The geneXpert MTB/Rif performed similarly to culture and better than bacilloscopy. Although positive cases with negative culture should be evaluated with caution, its routine use is important for the early detection of tuberculosis. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-02-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/222474 10.11606/s1518-8787.2024058005306 |
url |
https://www.revistas.usp.br/rsp/article/view/222474 |
identifier_str_mv |
10.11606/s1518-8787.2024058005306 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/222474/203061 https://www.revistas.usp.br/rsp/article/view/222474/203062 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2024 Mohanna Damasceno Arbués, Maria Lúcia Rosa Rossetti https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2024 Mohanna Damasceno Arbués, Maria Lúcia Rosa Rossetti https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/xml application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; v. 58 n. 1 (2024); 3 Revista de Saúde Pública; Vol. 58 Núm. 1 (2024); 3 Revista de Saúde Pública; Vol. 58 No. 1 (2024); 3 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221766387236864 |