Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Amorim Filho,Luiz
Data de Publicação: 2020
Outros Autores: Szwarcwald,Célia Landmann, Mateos,Sheila de Oliveira Garcia, Leon,Antonio Carlos Monteiro Ponce de, Medronho,Roberto de Andrade, Veloso,Valdiléa Gonçalves, Lopes,Josiane Iole França, Porto,Luis Cristovão de Moraes Sobrino, Chieppe,Alexandre, Werneck,Guilherme Loureiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100251
Resumo: ABSTRACT OBJECTIVE To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil. METHODS Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence. RESULTS The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3–4.7%), and the weighted prevalence was 3.8% (95%CI 3.1–4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7–4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6–4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence. CONCLUSIONS Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.
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spelling Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, BrazilCoronavirus Infections, immunologyBlood DonorsSerologic TestsSeroepidemiologic StudiesABSTRACT OBJECTIVE To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil. METHODS Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence. RESULTS The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3–4.7%), and the weighted prevalence was 3.8% (95%CI 3.1–4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7–4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6–4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence. CONCLUSIONS Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.Faculdade de Saúde Pública da Universidade de São Paulo2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100251Revista de Saúde Pública v.54 2020reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USP10.11606/s1518-8787.2020054002643info:eu-repo/semantics/openAccessAmorim Filho,LuizSzwarcwald,Célia LandmannMateos,Sheila de Oliveira GarciaLeon,Antonio Carlos Monteiro Ponce deMedronho,Roberto de AndradeVeloso,Valdiléa GonçalvesLopes,Josiane Iole FrançaPorto,Luis Cristovão de Moraes SobrinoChieppe,AlexandreWerneck,Guilherme Loureiroeng2020-07-02T00:00:00Zoai:scielo:S0034-89102020000100251Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0034-8910&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.phprevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2020-07-02T00:00Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
spellingShingle Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
Amorim Filho,Luiz
Coronavirus Infections, immunology
Blood Donors
Serologic Tests
Seroepidemiologic Studies
title_short Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title_full Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title_fullStr Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title_full_unstemmed Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title_sort Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
author Amorim Filho,Luiz
author_facet Amorim Filho,Luiz
Szwarcwald,Célia Landmann
Mateos,Sheila de Oliveira Garcia
Leon,Antonio Carlos Monteiro Ponce de
Medronho,Roberto de Andrade
Veloso,Valdiléa Gonçalves
Lopes,Josiane Iole França
Porto,Luis Cristovão de Moraes Sobrino
Chieppe,Alexandre
Werneck,Guilherme Loureiro
author_role author
author2 Szwarcwald,Célia Landmann
Mateos,Sheila de Oliveira Garcia
Leon,Antonio Carlos Monteiro Ponce de
Medronho,Roberto de Andrade
Veloso,Valdiléa Gonçalves
Lopes,Josiane Iole França
Porto,Luis Cristovão de Moraes Sobrino
Chieppe,Alexandre
Werneck,Guilherme Loureiro
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Amorim Filho,Luiz
Szwarcwald,Célia Landmann
Mateos,Sheila de Oliveira Garcia
Leon,Antonio Carlos Monteiro Ponce de
Medronho,Roberto de Andrade
Veloso,Valdiléa Gonçalves
Lopes,Josiane Iole França
Porto,Luis Cristovão de Moraes Sobrino
Chieppe,Alexandre
Werneck,Guilherme Loureiro
dc.subject.por.fl_str_mv Coronavirus Infections, immunology
Blood Donors
Serologic Tests
Seroepidemiologic Studies
topic Coronavirus Infections, immunology
Blood Donors
Serologic Tests
Seroepidemiologic Studies
description ABSTRACT OBJECTIVE To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil. METHODS Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence. RESULTS The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3–4.7%), and the weighted prevalence was 3.8% (95%CI 3.1–4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7–4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6–4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence. CONCLUSIONS Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100251
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102020000100251
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.11606/s1518-8787.2020054002643
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
dc.source.none.fl_str_mv Revista de Saúde Pública v.54 2020
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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