Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Amorim Filho, Luiz
Data de Publicação: 2020
Outros Autores: Szwarcwald, Célia Landmann, Mateos, Sheila de Oliveira Garcia, Ponce de Leon, Antonio Carlos Monteiro, Medronho, Roberto de Andrade, Veloso, Valdiléa Gonçalves, Lopes, Josiane Iole França, Porto, Luis Cristovão de Moraes Sobrino, Chieppe, Alexandre, Werneck, Guilherme Loureiro
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/176836
Resumo: OBJECTIVE: To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil. METHODS: Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence. RESULTS: The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3–4.7%), and the weighted prevalence was 3.8% (95%CI 3.1–4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7–4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6–4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence. CONCLUSIONS: Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.  
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spelling Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, BrazilCoronavirus Infections, immunologyBlood DonorsSerologic TestsSeroepidemiologic StudiesOBJECTIVE: To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil. METHODS: Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence. RESULTS: The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3–4.7%), and the weighted prevalence was 3.8% (95%CI 3.1–4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7–4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6–4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence. CONCLUSIONS: Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.  Universidade de São Paulo. Faculdade de Saúde Pública2020-07-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/xmlhttps://www.revistas.usp.br/rsp/article/view/17683610.11606/s1518-8787.2020054002643Revista de Saúde Pública; Vol. 54 (2020); 69Revista de Saúde Pública; Vol. 54 (2020); 69Revista de Saúde Pública; v. 54 (2020); 691518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPengporhttps://www.revistas.usp.br/rsp/article/view/176836/164160https://www.revistas.usp.br/rsp/article/view/176836/171047Copyright (c) 2020 Luiz Amorim Filho, Célia Landmann Szwarcwald, Sheila de Oliveira Garcia Mateos, Antonio Carlos Monteiro Ponce de Leon, Roberto de Andrade Medronho, Valdiléa Gonçalves Veloso, Josiane Iole França Lopes, Luis Cristovão de Moraes Sobrino Porto, Alexandre Chieppe, Guilherme Loureiro Werneck, Grupo Hemorio de Pesquisa em Covid-19http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAmorim Filho, LuizSzwarcwald, Célia Landmann Mateos, Sheila de Oliveira Garcia Ponce de Leon, Antonio Carlos Monteiro Medronho, Roberto de AndradeVeloso, Valdiléa Gonçalves Lopes, Josiane Iole França Porto, Luis Cristovão de Moraes Sobrino Chieppe, Alexandre Werneck, Guilherme Loureiro 2020-10-28T19:06:37Zoai:revistas.usp.br:article/176836Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2020-10-28T19:06:37Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
spellingShingle Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
Amorim Filho, Luiz
Coronavirus Infections, immunology
Blood Donors
Serologic Tests
Seroepidemiologic Studies
title_short Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title_full Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title_fullStr Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title_full_unstemmed Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
title_sort Seroprevalence of anti-SARS-CoV-2 among blood donors in Rio de Janeiro, Brazil
author Amorim Filho, Luiz
author_facet Amorim Filho, Luiz
Szwarcwald, Célia Landmann
Mateos, Sheila de Oliveira Garcia
Ponce de Leon, Antonio Carlos Monteiro
Medronho, Roberto de Andrade
Veloso, Valdiléa Gonçalves
Lopes, Josiane Iole França
Porto, Luis Cristovão de Moraes Sobrino
Chieppe, Alexandre
Werneck, Guilherme Loureiro
author_role author
author2 Szwarcwald, Célia Landmann
Mateos, Sheila de Oliveira Garcia
Ponce de Leon, Antonio Carlos Monteiro
Medronho, Roberto de Andrade
Veloso, Valdiléa Gonçalves
Lopes, Josiane Iole França
Porto, Luis Cristovão de Moraes Sobrino
Chieppe, Alexandre
Werneck, Guilherme Loureiro
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Amorim Filho, Luiz
Szwarcwald, Célia Landmann
Mateos, Sheila de Oliveira Garcia
Ponce de Leon, Antonio Carlos Monteiro
Medronho, Roberto de Andrade
Veloso, Valdiléa Gonçalves
Lopes, Josiane Iole França
Porto, Luis Cristovão de Moraes Sobrino
Chieppe, Alexandre
Werneck, Guilherme Loureiro
dc.subject.por.fl_str_mv Coronavirus Infections, immunology
Blood Donors
Serologic Tests
Seroepidemiologic Studies
topic Coronavirus Infections, immunology
Blood Donors
Serologic Tests
Seroepidemiologic Studies
description OBJECTIVE: To estimate the seroprevalence of antibodies to SARS-CoV-2 among blood donors in the state of Rio de Janeiro, Brazil. METHODS: Data were collected on 2,857 blood donors from April 14 to 27, 2020. This study reports crude prevalence of antibodies to SARS-CoV-2, population weighted prevalence for the state, and prevalence adjusted for test sensitivity and specificity. Logistic regression models were used to establish the correlates of SARS-CoV-2 prevalence. For the analysis, we considered collection period and site, sociodemographic characteristics, and place of residence. RESULTS: The proportion of positive tests for SARS-Cov-2, without any adjustment, was 4.0% (95%CI 3.3–4.7%), and the weighted prevalence was 3.8% (95%CI 3.1–4.5%). We found lower estimates after adjusting for test sensitivity and specificity: 3.6% (95%CI 2.7–4.4%) for the non-weighted prevalence, and 3.3% (95%CI 2.6–4.1%) for the weighted prevalence. Collection period was the variable most significantly associated with crude prevalence: the later the period, the higher the prevalence. Regarding sociodemographic characteristics, the younger the blood donor, the higher the prevalence, and the lower the education level, the higher the odds of testing positive for SARS-Cov-2 antibody. We found similar results for weighted prevalence. CONCLUSIONS: Our findings comply with some basic premises: the increasing trend over time, as the epidemic curve in the state is still on the rise; and the higher prevalence among both the youngest, for moving around more than older age groups, and the less educated, for encountering more difficulties in following social distancing recommendations. Despite the study limitations, we may infer that Rio de Janeiro is far from reaching the required levels of herd immunity against SARS-CoV-2.  
publishDate 2020
dc.date.none.fl_str_mv 2020-07-06
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dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/176836
10.11606/s1518-8787.2020054002643
url https://www.revistas.usp.br/rsp/article/view/176836
identifier_str_mv 10.11606/s1518-8787.2020054002643
dc.language.iso.fl_str_mv eng
por
language eng
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dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/176836/164160
https://www.revistas.usp.br/rsp/article/view/176836/171047
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
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dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 54 (2020); 69
Revista de Saúde Pública; Vol. 54 (2020); 69
Revista de Saúde Pública; v. 54 (2020); 69
1518-8787
0034-8910
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