Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate
Autor(a) principal: | |
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Data de Publicação: | 1973 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Saúde Pública |
Texto Completo: | https://www.revistas.usp.br/rsp/article/view/4704 |
Resumo: | The treatment of Cutaneous Leishmaniasis with Cicloguanil Pamoate ("Comolar" Park-Davis), in Amapa Territory, North of the Amazon River, Brazil, is reported. Complete cicatrization of lesions was observed in 33 patients of which 28 received a single dose and 5 were treated with a second injection of the drug. Diagnosis was made by direct microscopic examination and the finding of Leishmaniae. Age of the lesions varied from 8 days to 12 month, 82% being from 8 to 30 days. The average time necessary for cicatrization was 104 days, varying from 60 to 170 days for patients receiving a single dose. Complete cicatrization among patients that received a second dose occurred in an average time of 163 days after the first treatment and 85 days after the second dose. After cicatrization the patients were kept under observation for an average period of 8.4 months, varying from 3 to 19 months. It was shown that the cure of the lesions requires a rather long period after the first dose, with recrudescence in several cases and requiring in some patients a second dose to accelerate the cure. |
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Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate Cicatrização de lesões cutâneas de leishmaniose americana com dose única de pamoato de cicloguanil Leishmaniose^i1^squimioteraCicloguanilTerapêuticaLeishmaniasiscutaneousChemotherapyCycloguanil pamoate The treatment of Cutaneous Leishmaniasis with Cicloguanil Pamoate ("Comolar" Park-Davis), in Amapa Territory, North of the Amazon River, Brazil, is reported. Complete cicatrization of lesions was observed in 33 patients of which 28 received a single dose and 5 were treated with a second injection of the drug. Diagnosis was made by direct microscopic examination and the finding of Leishmaniae. Age of the lesions varied from 8 days to 12 month, 82% being from 8 to 30 days. The average time necessary for cicatrization was 104 days, varying from 60 to 170 days for patients receiving a single dose. Complete cicatrization among patients that received a second dose occurred in an average time of 163 days after the first treatment and 85 days after the second dose. After cicatrization the patients were kept under observation for an average period of 8.4 months, varying from 3 to 19 months. It was shown that the cure of the lesions requires a rather long period after the first dose, with recrudescence in several cases and requiring in some patients a second dose to accelerate the cure. Relata-se a completa cicatrização de lesões de leishmaniose tegumentar americana, com Pamoato de Cicloguanil (Comolar Parke-Davis) em 33 pacientes, dos quais 28 receberam dose única e 5 dose dupla desse quimioterápico. O diagnóstico foi comprovado pela presença de leishmanias ao exame direto de laboratório. A idade das lesões variou de 8 dias até 12 meses, com 82% dos casos entre 8 e 30 dias. O tempo médio de cicatrização foi de 104 dias variando entre 60 e 170 dias, para os doentes que receberam apenas uma dose do medicamento. Os doentes que receberam duas doses tiveram a completa cicatrização com tempo médio de 163 dias, após a primeira dose e 85 dias após a segunda. Após a cicatrização, os doentes foram controlados por um período médio de 8,4 meses variando entre 3 e 19 meses. A observação mostrou que a cura das lesões é de forma mais retardada, podendo em muitos casos haver uma recrudescência das lesões e, em alguns casos, uma segunda dose acelera a cura. Universidade de São Paulo. Faculdade de Saúde Pública1973-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/470410.1590/S0034-89101973000400003Revista de Saúde Pública; Vol. 7 No. 4 (1973); 335-341 Revista de Saúde Pública; Vol. 7 Núm. 4 (1973); 335-341 Revista de Saúde Pública; v. 7 n. 4 (1973); 335-341 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/4704/6234Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessGusmão, Hermelino HerbsterSouza, José Antonio Gomes de2012-04-27T19:07:55Zoai:revistas.usp.br:article/4704Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-04-27T19:07:55Revista de Saúde Pública - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate Cicatrização de lesões cutâneas de leishmaniose americana com dose única de pamoato de cicloguanil |
title |
Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate |
spellingShingle |
Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate Gusmão, Hermelino Herbster Leishmaniose^i1^squimiotera Cicloguanil Terapêutica Leishmaniasis cutaneous Chemotherapy Cycloguanil pamoate |
title_short |
Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate |
title_full |
Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate |
title_fullStr |
Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate |
title_full_unstemmed |
Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate |
title_sort |
Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate |
author |
Gusmão, Hermelino Herbster |
author_facet |
Gusmão, Hermelino Herbster Souza, José Antonio Gomes de |
author_role |
author |
author2 |
Souza, José Antonio Gomes de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Gusmão, Hermelino Herbster Souza, José Antonio Gomes de |
dc.subject.por.fl_str_mv |
Leishmaniose^i1^squimiotera Cicloguanil Terapêutica Leishmaniasis cutaneous Chemotherapy Cycloguanil pamoate |
topic |
Leishmaniose^i1^squimiotera Cicloguanil Terapêutica Leishmaniasis cutaneous Chemotherapy Cycloguanil pamoate |
description |
The treatment of Cutaneous Leishmaniasis with Cicloguanil Pamoate ("Comolar" Park-Davis), in Amapa Territory, North of the Amazon River, Brazil, is reported. Complete cicatrization of lesions was observed in 33 patients of which 28 received a single dose and 5 were treated with a second injection of the drug. Diagnosis was made by direct microscopic examination and the finding of Leishmaniae. Age of the lesions varied from 8 days to 12 month, 82% being from 8 to 30 days. The average time necessary for cicatrization was 104 days, varying from 60 to 170 days for patients receiving a single dose. Complete cicatrization among patients that received a second dose occurred in an average time of 163 days after the first treatment and 85 days after the second dose. After cicatrization the patients were kept under observation for an average period of 8.4 months, varying from 3 to 19 months. It was shown that the cure of the lesions requires a rather long period after the first dose, with recrudescence in several cases and requiring in some patients a second dose to accelerate the cure. |
publishDate |
1973 |
dc.date.none.fl_str_mv |
1973-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/4704 10.1590/S0034-89101973000400003 |
url |
https://www.revistas.usp.br/rsp/article/view/4704 |
identifier_str_mv |
10.1590/S0034-89101973000400003 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rsp/article/view/4704/6234 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Revista de Saúde Pública info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Revista de Saúde Pública |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Saúde Pública |
dc.source.none.fl_str_mv |
Revista de Saúde Pública; Vol. 7 No. 4 (1973); 335-341 Revista de Saúde Pública; Vol. 7 Núm. 4 (1973); 335-341 Revista de Saúde Pública; v. 7 n. 4 (1973); 335-341 1518-8787 0034-8910 reponame:Revista de Saúde Pública instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista de Saúde Pública |
collection |
Revista de Saúde Pública |
repository.name.fl_str_mv |
Revista de Saúde Pública - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
revsp@org.usp.br||revsp1@usp.br |
_version_ |
1800221768410988544 |