Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate

Detalhes bibliográficos
Autor(a) principal: Gusmão, Hermelino Herbster
Data de Publicação: 1973
Outros Autores: Souza, José Antonio Gomes de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Saúde Pública
Texto Completo: https://www.revistas.usp.br/rsp/article/view/4704
Resumo: The treatment of Cutaneous Leishmaniasis with Cicloguanil Pamoate ("Comolar" Park-Davis), in Amapa Territory, North of the Amazon River, Brazil, is reported. Complete cicatrization of lesions was observed in 33 patients of which 28 received a single dose and 5 were treated with a second injection of the drug. Diagnosis was made by direct microscopic examination and the finding of Leishmaniae. Age of the lesions varied from 8 days to 12 month, 82% being from 8 to 30 days. The average time necessary for cicatrization was 104 days, varying from 60 to 170 days for patients receiving a single dose. Complete cicatrization among patients that received a second dose occurred in an average time of 163 days after the first treatment and 85 days after the second dose. After cicatrization the patients were kept under observation for an average period of 8.4 months, varying from 3 to 19 months. It was shown that the cure of the lesions requires a rather long period after the first dose, with recrudescence in several cases and requiring in some patients a second dose to accelerate the cure.
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spelling Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate Cicatrização de lesões cutâneas de leishmaniose americana com dose única de pamoato de cicloguanil Leishmaniose^i1^squimioteraCicloguanilTerapêuticaLeishmaniasiscutaneousChemotherapyCycloguanil pamoate The treatment of Cutaneous Leishmaniasis with Cicloguanil Pamoate ("Comolar" Park-Davis), in Amapa Territory, North of the Amazon River, Brazil, is reported. Complete cicatrization of lesions was observed in 33 patients of which 28 received a single dose and 5 were treated with a second injection of the drug. Diagnosis was made by direct microscopic examination and the finding of Leishmaniae. Age of the lesions varied from 8 days to 12 month, 82% being from 8 to 30 days. The average time necessary for cicatrization was 104 days, varying from 60 to 170 days for patients receiving a single dose. Complete cicatrization among patients that received a second dose occurred in an average time of 163 days after the first treatment and 85 days after the second dose. After cicatrization the patients were kept under observation for an average period of 8.4 months, varying from 3 to 19 months. It was shown that the cure of the lesions requires a rather long period after the first dose, with recrudescence in several cases and requiring in some patients a second dose to accelerate the cure. Relata-se a completa cicatrização de lesões de leishmaniose tegumentar americana, com Pamoato de Cicloguanil (Comolar Parke-Davis) em 33 pacientes, dos quais 28 receberam dose única e 5 dose dupla desse quimioterápico. O diagnóstico foi comprovado pela presença de leishmanias ao exame direto de laboratório. A idade das lesões variou de 8 dias até 12 meses, com 82% dos casos entre 8 e 30 dias. O tempo médio de cicatrização foi de 104 dias variando entre 60 e 170 dias, para os doentes que receberam apenas uma dose do medicamento. Os doentes que receberam duas doses tiveram a completa cicatrização com tempo médio de 163 dias, após a primeira dose e 85 dias após a segunda. Após a cicatrização, os doentes foram controlados por um período médio de 8,4 meses variando entre 3 e 19 meses. A observação mostrou que a cura das lesões é de forma mais retardada, podendo em muitos casos haver uma recrudescência das lesões e, em alguns casos, uma segunda dose acelera a cura. Universidade de São Paulo. Faculdade de Saúde Pública1973-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rsp/article/view/470410.1590/S0034-89101973000400003Revista de Saúde Pública; Vol. 7 No. 4 (1973); 335-341 Revista de Saúde Pública; Vol. 7 Núm. 4 (1973); 335-341 Revista de Saúde Pública; v. 7 n. 4 (1973); 335-341 1518-87870034-8910reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USPporhttps://www.revistas.usp.br/rsp/article/view/4704/6234Copyright (c) 2017 Revista de Saúde Públicainfo:eu-repo/semantics/openAccessGusmão, Hermelino HerbsterSouza, José Antonio Gomes de2012-04-27T19:07:55Zoai:revistas.usp.br:article/4704Revistahttps://www.revistas.usp.br/rsp/indexONGhttps://www.revistas.usp.br/rsp/oairevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2012-04-27T19:07:55Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate
Cicatrização de lesões cutâneas de leishmaniose americana com dose única de pamoato de cicloguanil
title Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate
spellingShingle Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate
Gusmão, Hermelino Herbster
Leishmaniose^i1^squimiotera
Cicloguanil
Terapêutica
Leishmaniasis
cutaneous
Chemotherapy
Cycloguanil pamoate
title_short Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate
title_full Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate
title_fullStr Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate
title_full_unstemmed Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate
title_sort Cicatrization of lesions of cutaneous leishmaniasis with a single dose of cicloguanil pamoate
author Gusmão, Hermelino Herbster
author_facet Gusmão, Hermelino Herbster
Souza, José Antonio Gomes de
author_role author
author2 Souza, José Antonio Gomes de
author2_role author
dc.contributor.author.fl_str_mv Gusmão, Hermelino Herbster
Souza, José Antonio Gomes de
dc.subject.por.fl_str_mv Leishmaniose^i1^squimiotera
Cicloguanil
Terapêutica
Leishmaniasis
cutaneous
Chemotherapy
Cycloguanil pamoate
topic Leishmaniose^i1^squimiotera
Cicloguanil
Terapêutica
Leishmaniasis
cutaneous
Chemotherapy
Cycloguanil pamoate
description The treatment of Cutaneous Leishmaniasis with Cicloguanil Pamoate ("Comolar" Park-Davis), in Amapa Territory, North of the Amazon River, Brazil, is reported. Complete cicatrization of lesions was observed in 33 patients of which 28 received a single dose and 5 were treated with a second injection of the drug. Diagnosis was made by direct microscopic examination and the finding of Leishmaniae. Age of the lesions varied from 8 days to 12 month, 82% being from 8 to 30 days. The average time necessary for cicatrization was 104 days, varying from 60 to 170 days for patients receiving a single dose. Complete cicatrization among patients that received a second dose occurred in an average time of 163 days after the first treatment and 85 days after the second dose. After cicatrization the patients were kept under observation for an average period of 8.4 months, varying from 3 to 19 months. It was shown that the cure of the lesions requires a rather long period after the first dose, with recrudescence in several cases and requiring in some patients a second dose to accelerate the cure.
publishDate 1973
dc.date.none.fl_str_mv 1973-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rsp/article/view/4704
10.1590/S0034-89101973000400003
url https://www.revistas.usp.br/rsp/article/view/4704
identifier_str_mv 10.1590/S0034-89101973000400003
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rsp/article/view/4704/6234
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Saúde Pública
dc.source.none.fl_str_mv Revista de Saúde Pública; Vol. 7 No. 4 (1973); 335-341
Revista de Saúde Pública; Vol. 7 Núm. 4 (1973); 335-341
Revista de Saúde Pública; v. 7 n. 4 (1973); 335-341
1518-8787
0034-8910
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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