Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil

Detalhes bibliográficos
Autor(a) principal: Monjour,Loic
Data de Publicação: 1994
Outros Autores: Neogy,Asit B., Vouldoukis,Ioannis, Silva,Otamires A., Boisnic,Sylvie, Brito,Maria Edileuza F., Lesot,Annette, Vignot,Nicole, Martins,Jane S., Jardim,Marcio L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761994000300034
Resumo: In a complete study in 25 patients with American cutaneous leishmaniasis, caused by Leishmania braziliensis complex, immunotherapeutic efficacy of parasite derived antigen (94-67 KD) has been compared to antimonial therapy. Additionally, to delineate the mechanism of therapeutic success, microscopical features of immune response in active lesions and healed or non-healed lesions following therapy were analyzed. The results showed that cure rates in immunotherapy and chemoterapy were equal (>83 por cento). The immunohistochemical changes in two therapeutic groups were also largely similar. The analysis of humoral and cellular immune response suggest that appropriate stimulation of T helper cells in the lesion site, in association with one or more cytokines, play a key role in the healing process.
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spelling Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazilhuman cutaneous leishmaniasisBrazilchemotherapyimmunotherapyIn a complete study in 25 patients with American cutaneous leishmaniasis, caused by Leishmania braziliensis complex, immunotherapeutic efficacy of parasite derived antigen (94-67 KD) has been compared to antimonial therapy. Additionally, to delineate the mechanism of therapeutic success, microscopical features of immune response in active lesions and healed or non-healed lesions following therapy were analyzed. The results showed that cure rates in immunotherapy and chemoterapy were equal (>83 por cento). The immunohistochemical changes in two therapeutic groups were also largely similar. The analysis of humoral and cellular immune response suggest that appropriate stimulation of T helper cells in the lesion site, in association with one or more cytokines, play a key role in the healing process.Instituto Oswaldo Cruz, Ministério da Saúde1994-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761994000300034Memórias do Instituto Oswaldo Cruz v.89 n.3 1994reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761994000300034info:eu-repo/semantics/openAccessMonjour,LoicNeogy,Asit B.Vouldoukis,IoannisSilva,Otamires A.Boisnic,SylvieBrito,Maria Edileuza F.Lesot,AnnetteVignot,NicoleMartins,Jane S.Jardim,Marcio L.eng2020-04-25T17:47:18Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:06:10.651Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
title Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
spellingShingle Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
Monjour,Loic
human cutaneous leishmaniasis
Brazil
chemotherapy
immunotherapy
title_short Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
title_full Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
title_fullStr Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
title_full_unstemmed Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
title_sort Exploitation of parasite derived antigen in therapeutic success of human cutaneous leishmaniasis in Brazil
author Monjour,Loic
author_facet Monjour,Loic
Neogy,Asit B.
Vouldoukis,Ioannis
Silva,Otamires A.
Boisnic,Sylvie
Brito,Maria Edileuza F.
Lesot,Annette
Vignot,Nicole
Martins,Jane S.
Jardim,Marcio L.
author_role author
author2 Neogy,Asit B.
Vouldoukis,Ioannis
Silva,Otamires A.
Boisnic,Sylvie
Brito,Maria Edileuza F.
Lesot,Annette
Vignot,Nicole
Martins,Jane S.
Jardim,Marcio L.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Monjour,Loic
Neogy,Asit B.
Vouldoukis,Ioannis
Silva,Otamires A.
Boisnic,Sylvie
Brito,Maria Edileuza F.
Lesot,Annette
Vignot,Nicole
Martins,Jane S.
Jardim,Marcio L.
dc.subject.por.fl_str_mv human cutaneous leishmaniasis
Brazil
chemotherapy
immunotherapy
topic human cutaneous leishmaniasis
Brazil
chemotherapy
immunotherapy
dc.description.none.fl_txt_mv In a complete study in 25 patients with American cutaneous leishmaniasis, caused by Leishmania braziliensis complex, immunotherapeutic efficacy of parasite derived antigen (94-67 KD) has been compared to antimonial therapy. Additionally, to delineate the mechanism of therapeutic success, microscopical features of immune response in active lesions and healed or non-healed lesions following therapy were analyzed. The results showed that cure rates in immunotherapy and chemoterapy were equal (>83 por cento). The immunohistochemical changes in two therapeutic groups were also largely similar. The analysis of humoral and cellular immune response suggest that appropriate stimulation of T helper cells in the lesion site, in association with one or more cytokines, play a key role in the healing process.
description In a complete study in 25 patients with American cutaneous leishmaniasis, caused by Leishmania braziliensis complex, immunotherapeutic efficacy of parasite derived antigen (94-67 KD) has been compared to antimonial therapy. Additionally, to delineate the mechanism of therapeutic success, microscopical features of immune response in active lesions and healed or non-healed lesions following therapy were analyzed. The results showed that cure rates in immunotherapy and chemoterapy were equal (>83 por cento). The immunohistochemical changes in two therapeutic groups were also largely similar. The analysis of humoral and cellular immune response suggest that appropriate stimulation of T helper cells in the lesion site, in association with one or more cytokines, play a key role in the healing process.
publishDate 1994
dc.date.none.fl_str_mv 1994-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761994000300034
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761994000300034
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761994000300034
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.89 n.3 1994
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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