A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties

Detalhes bibliográficos
Autor(a) principal: Montaña, Jorge Andrés
Data de Publicação: 2018
Outros Autores: Perez, León Darío, Baena, Yolima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/153783
Resumo: Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the selfassembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release.
id USP-31_20fcebaa702e76006418abe373f4b2d3
oai_identifier_str oai:revistas.usp.br:article/153783
network_acronym_str USP-31
network_name_str Brazilian Journal of Pharmaceutical Sciences
repository_id_str
spelling A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical propertiesInterpolyelectrolyte complexPharmacotechnical propertiesDexibuprofenControlled releaseHydrophillic matrixInterpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the selfassembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2018-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/15378310.1590/s2175-9790201800021718Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17183Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17183Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e171832175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/153783/150173Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessMontaña, Jorge AndrésPerez, León DaríoBaena, Yolima2019-03-17T13:48:38Zoai:revistas.usp.br:article/153783Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2019-03-17T13:48:38Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
title A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
spellingShingle A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
Montaña, Jorge Andrés
Interpolyelectrolyte complex
Pharmacotechnical properties
Dexibuprofen
Controlled release
Hydrophillic matrix
title_short A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
title_full A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
title_fullStr A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
title_full_unstemmed A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
title_sort A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
author Montaña, Jorge Andrés
author_facet Montaña, Jorge Andrés
Perez, León Darío
Baena, Yolima
author_role author
author2 Perez, León Darío
Baena, Yolima
author2_role author
author
dc.contributor.author.fl_str_mv Montaña, Jorge Andrés
Perez, León Darío
Baena, Yolima
dc.subject.por.fl_str_mv Interpolyelectrolyte complex
Pharmacotechnical properties
Dexibuprofen
Controlled release
Hydrophillic matrix
topic Interpolyelectrolyte complex
Pharmacotechnical properties
Dexibuprofen
Controlled release
Hydrophillic matrix
description Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the selfassembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release.
publishDate 2018
dc.date.none.fl_str_mv 2018-07-26
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/153783
10.1590/s2175-9790201800021718
url https://www.revistas.usp.br/bjps/article/view/153783
identifier_str_mv 10.1590/s2175-9790201800021718
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/153783/150173
dc.rights.driver.fl_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17183
Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17183
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e17183
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
_version_ 1800222913708687360

Registros relacionados