Anti-inflammatory and healing action of oral gel containing borneol monoterpene in chemotherapy-induced mucositis in rats ( Rattus norvegicus )

• Autor(a) principal: Nascimento-Júnior, Braz José do
• Data de Publicação: 2017
• Outros Autores: Brito, Lucas de Souza, Barros, Walquíria Nunes, Gonçalves, Daniela Marques, Matos, Luana de Souza, Nascimento, Cínthia Reyjane Borges, Ribeiro, Luciano Augusto de Araújo, Lima, Ricardo Santana de, Silva-Júnior, René Geraldo Cordeiro, Reis, Sílvio Alan Gonçalves Bomfim, Gonçalves, Talita Mota, Amorim, Elba Lúcia Cavalcanti de
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Pharmaceutical Sciences
• Texto Completo: https://www.revistas.usp.br/bjps/article/view/134900
• topic: Chemotherapy; Oral gel/Borneol monoterpene/effects; Oral gel/Borneol monoterpene/action anti-inflammatory; Oral gel/Borneol monoterpene/healing action; Bornyl alcohol/effects; Palliative care

The aim of this study was to investigate the effect of gels containing the monoterpene borneol in induced oral mucositis using an animal model. Gels were prepared with borneol at 1.2% and 2.4% (w/w). Oral mucositis was induced by administration of three doses of 5-fluorouracil (30 mg/kg, i.p.) and injury with acetic acid (50%, v/v) soaked in filter paper applied to right cheek mucosa for 60s. Four subgroups comprising 12 animals each were formed. Six animals from each group were sacrificed at days seven and fourteen after oral mucositis induction. Mucous samples were processed and stained with hematoxylin-eosin and Masson’s Trichrome. The semiquantitative evaluation involved observation of inflammatory parameters. ImageJ® software was used in the quantitative evaluation. For statistical analyses, Two-way ANOVA, followed by Tukey’s post-test (p