Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysis

Detalhes bibliográficos
Autor(a) principal: Alexandre Júnior, Ronaldo Gomes
Data de Publicação: 2023
Outros Autores: Lima, Paloma Araújo, Portela, Mileyde Ponte, Lima, João Lucas de Farias, Lima, Elisangela Costa, Fonteles, Marta Maria de França
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/207331
Resumo: In pediatrics, drug therapy is commonly performed through adaptations of the dosage forms to adult use, increasing the risk of adverse drug reactions. In this context, studies assessing the severity and avoidability of the adverse reactions in children, especially those caused by antimicrobials, are still scarce. This work aimed to investigate suspected antimicrobial adverse reactions (ATM-ADRs) in pediatric patients admitted to a public hospital in northeastern Brazil, focusing on causality and avoidability analysis. A cohort study was carried out over a period of six months in a 64-bed pediatric unit. The incidence of suspected adverse reactions caused by antimicrobials was 14.65%. Most reactions were rated as probable (89.13%), with moderate severity (84.78%) and possibly avoidable (45.65%). The analysis indicated that the use of a larger number of medications (p<0.0001) and longer hospital stay (p=0.004) were related to the occurrence of ATM-ADR. Our findings demonstrated that almost half of the suspected reactions could be prevented and that the antimicrobial’s clinical management is relevant in this context. Besides, increasingly accurate adverse reaction classification instruments are essential. These results can support the development of therapeutic guidelines addressed to a safe and effective pharmacotherapy in the pediatric area.
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spelling Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysisAdverse Drug ReactionsPediatricsAntimicrobialsCausalityAvoidabilityIn pediatrics, drug therapy is commonly performed through adaptations of the dosage forms to adult use, increasing the risk of adverse drug reactions. In this context, studies assessing the severity and avoidability of the adverse reactions in children, especially those caused by antimicrobials, are still scarce. This work aimed to investigate suspected antimicrobial adverse reactions (ATM-ADRs) in pediatric patients admitted to a public hospital in northeastern Brazil, focusing on causality and avoidability analysis. A cohort study was carried out over a period of six months in a 64-bed pediatric unit. The incidence of suspected adverse reactions caused by antimicrobials was 14.65%. Most reactions were rated as probable (89.13%), with moderate severity (84.78%) and possibly avoidable (45.65%). The analysis indicated that the use of a larger number of medications (p<0.0001) and longer hospital stay (p=0.004) were related to the occurrence of ATM-ADR. Our findings demonstrated that almost half of the suspected reactions could be prevented and that the antimicrobial’s clinical management is relevant in this context. Besides, increasingly accurate adverse reaction classification instruments are essential. These results can support the development of therapeutic guidelines addressed to a safe and effective pharmacotherapy in the pediatric area.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-01-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20733110.1590/s2175-97902022000X20799Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/207331/197598Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAlexandre Júnior, Ronaldo Gomes Lima, Paloma AraújoPortela, Mileyde PonteLima, João Lucas de FariasLima, Elisangela CostaFonteles, Marta Maria de França2023-08-28T19:51:46Zoai:revistas.usp.br:article/207331Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-08-28T19:51:46Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysis
title Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysis
spellingShingle Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysis
Alexandre Júnior, Ronaldo Gomes
Adverse Drug Reactions
Pediatrics
Antimicrobials
Causality
Avoidability
title_short Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysis
title_full Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysis
title_fullStr Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysis
title_full_unstemmed Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysis
title_sort Adverse reactions caused by antimicrobials in hospitalized pediatric patients: causality and avoidability analysis
author Alexandre Júnior, Ronaldo Gomes
author_facet Alexandre Júnior, Ronaldo Gomes
Lima, Paloma Araújo
Portela, Mileyde Ponte
Lima, João Lucas de Farias
Lima, Elisangela Costa
Fonteles, Marta Maria de França
author_role author
author2 Lima, Paloma Araújo
Portela, Mileyde Ponte
Lima, João Lucas de Farias
Lima, Elisangela Costa
Fonteles, Marta Maria de França
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Alexandre Júnior, Ronaldo Gomes
Lima, Paloma Araújo
Portela, Mileyde Ponte
Lima, João Lucas de Farias
Lima, Elisangela Costa
Fonteles, Marta Maria de França
dc.subject.por.fl_str_mv Adverse Drug Reactions
Pediatrics
Antimicrobials
Causality
Avoidability
topic Adverse Drug Reactions
Pediatrics
Antimicrobials
Causality
Avoidability
description In pediatrics, drug therapy is commonly performed through adaptations of the dosage forms to adult use, increasing the risk of adverse drug reactions. In this context, studies assessing the severity and avoidability of the adverse reactions in children, especially those caused by antimicrobials, are still scarce. This work aimed to investigate suspected antimicrobial adverse reactions (ATM-ADRs) in pediatric patients admitted to a public hospital in northeastern Brazil, focusing on causality and avoidability analysis. A cohort study was carried out over a period of six months in a 64-bed pediatric unit. The incidence of suspected adverse reactions caused by antimicrobials was 14.65%. Most reactions were rated as probable (89.13%), with moderate severity (84.78%) and possibly avoidable (45.65%). The analysis indicated that the use of a larger number of medications (p<0.0001) and longer hospital stay (p=0.004) were related to the occurrence of ATM-ADR. Our findings demonstrated that almost half of the suspected reactions could be prevented and that the antimicrobial’s clinical management is relevant in this context. Besides, increasingly accurate adverse reaction classification instruments are essential. These results can support the development of therapeutic guidelines addressed to a safe and effective pharmacotherapy in the pediatric area.
publishDate 2023
dc.date.none.fl_str_mv 2023-01-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/207331
10.1590/s2175-97902022000X20799
url https://www.revistas.usp.br/bjps/article/view/207331
identifier_str_mv 10.1590/s2175-97902022000X20799
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/207331/197598
dc.rights.driver.fl_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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