Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/180954 |
Resumo: | Cyanobacteria are phytoplanktonic microorganisms that are susceptible to the deleterious effects of pharmaceutical residues in the aquatic environment, which poses a challenge to the environment exposed to diverse pharmaceutical products and their potential effects. The objective of this study was to evaluate the effects of the antibiotic substances ciprofloxacin and chlorhexidine in pharmaceutical preparations on the growth and production of chlorophyll of two cyanobacterial strains, Microcystis aeruginosa and Microcystis panniformis, isolated from a lake in a Brazilian environmental protection area. The EC50 and EC10 of chlorhexidine for M. aeruginosa were 206.4 μg/L and 108.5 μg/L, respectively, and for M. panniformis were 171.4 μg/L and 116.6 μg/L, respectively. The EC50 and EC10 of ciprofloxacin for M. aeruginosa were 17.24 μg/L and 3.21 μg/L, respectively, and for M. panniformis were 13.56 μg/L and 1.50 μg/L, respectively. The toxicity of the antibiotic ciprofloxacin (drug) and chlorhexidine (standard solution) to the Microcystis species was demonstrated, and these species were both very sensitive to ciprofloxacin. Our results suggest that the strains of M. aeruginosa and M. panniformis may be affected by exposure to residues of ciprofloxacin (>1.5 μg/L), which may represent a risk to the survival of aquatic species. |
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Brazilian Journal of Pharmaceutical Sciences |
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Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteriaEcotoxicological testAntibioticsAntisepticContaminants of emerging interestGrowth inhibitionCyanobacteria are phytoplanktonic microorganisms that are susceptible to the deleterious effects of pharmaceutical residues in the aquatic environment, which poses a challenge to the environment exposed to diverse pharmaceutical products and their potential effects. The objective of this study was to evaluate the effects of the antibiotic substances ciprofloxacin and chlorhexidine in pharmaceutical preparations on the growth and production of chlorophyll of two cyanobacterial strains, Microcystis aeruginosa and Microcystis panniformis, isolated from a lake in a Brazilian environmental protection area. The EC50 and EC10 of chlorhexidine for M. aeruginosa were 206.4 μg/L and 108.5 μg/L, respectively, and for M. panniformis were 171.4 μg/L and 116.6 μg/L, respectively. The EC50 and EC10 of ciprofloxacin for M. aeruginosa were 17.24 μg/L and 3.21 μg/L, respectively, and for M. panniformis were 13.56 μg/L and 1.50 μg/L, respectively. The toxicity of the antibiotic ciprofloxacin (drug) and chlorhexidine (standard solution) to the Microcystis species was demonstrated, and these species were both very sensitive to ciprofloxacin. Our results suggest that the strains of M. aeruginosa and M. panniformis may be affected by exposure to residues of ciprofloxacin (>1.5 μg/L), which may represent a risk to the survival of aquatic species.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18095410.1590/s2175-97902019000217661Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17661 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17661 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17661 2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/180954/167977Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAzevedo, Fernanda Cristina Rezende Vaz, Izabela Cristina Dias Barbosa, Francisco Antônio Rodrigues Magalhães, Sérgia Maria Starling 2021-01-19T16:47:29Zoai:revistas.usp.br:article/180954Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-01-19T16:47:29Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria |
title |
Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria |
spellingShingle |
Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria Azevedo, Fernanda Cristina Rezende Ecotoxicological test Antibiotics Antiseptic Contaminants of emerging interest Growth inhibition |
title_short |
Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria |
title_full |
Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria |
title_fullStr |
Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria |
title_full_unstemmed |
Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria |
title_sort |
Toxicological effects of ciprofloxacin and chlorhexidine on growth and chlorophyll a synthesis of freshwater cyanobacteria |
author |
Azevedo, Fernanda Cristina Rezende |
author_facet |
Azevedo, Fernanda Cristina Rezende Vaz, Izabela Cristina Dias Barbosa, Francisco Antônio Rodrigues Magalhães, Sérgia Maria Starling |
author_role |
author |
author2 |
Vaz, Izabela Cristina Dias Barbosa, Francisco Antônio Rodrigues Magalhães, Sérgia Maria Starling |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Azevedo, Fernanda Cristina Rezende Vaz, Izabela Cristina Dias Barbosa, Francisco Antônio Rodrigues Magalhães, Sérgia Maria Starling |
dc.subject.por.fl_str_mv |
Ecotoxicological test Antibiotics Antiseptic Contaminants of emerging interest Growth inhibition |
topic |
Ecotoxicological test Antibiotics Antiseptic Contaminants of emerging interest Growth inhibition |
description |
Cyanobacteria are phytoplanktonic microorganisms that are susceptible to the deleterious effects of pharmaceutical residues in the aquatic environment, which poses a challenge to the environment exposed to diverse pharmaceutical products and their potential effects. The objective of this study was to evaluate the effects of the antibiotic substances ciprofloxacin and chlorhexidine in pharmaceutical preparations on the growth and production of chlorophyll of two cyanobacterial strains, Microcystis aeruginosa and Microcystis panniformis, isolated from a lake in a Brazilian environmental protection area. The EC50 and EC10 of chlorhexidine for M. aeruginosa were 206.4 μg/L and 108.5 μg/L, respectively, and for M. panniformis were 171.4 μg/L and 116.6 μg/L, respectively. The EC50 and EC10 of ciprofloxacin for M. aeruginosa were 17.24 μg/L and 3.21 μg/L, respectively, and for M. panniformis were 13.56 μg/L and 1.50 μg/L, respectively. The toxicity of the antibiotic ciprofloxacin (drug) and chlorhexidine (standard solution) to the Microcystis species was demonstrated, and these species were both very sensitive to ciprofloxacin. Our results suggest that the strains of M. aeruginosa and M. panniformis may be affected by exposure to residues of ciprofloxacin (>1.5 μg/L), which may represent a risk to the survival of aquatic species. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/180954 10.1590/s2175-97902019000217661 |
url |
https://www.revistas.usp.br/bjps/article/view/180954 |
identifier_str_mv |
10.1590/s2175-97902019000217661 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/180954/167977 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17661 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e17661 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e17661 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222914562228224 |