A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/211574 |
Resumo: | Teicoplanin is a glycopeptide antibiotic commonly used to treat Gram-positive bacterial infections in the clinic. The aim of this study was to provide a therapeutic reference for the clinical application and dosage regimen adjustment of teicoplanin by identifying factors associated with its plasma trough concentration (Ctrough). A retrospective study was performed on patients with suspected or documented Gram-positive infections who were hospitalized from November 2017 to January 2020 and treated with teicoplanin while undergoing routine therapeutic drug monitoring (TDM). A total of 112 Ctrough trough measurements were obtained from 72 patients were included in this study. SPSS software was used for correlation analysis and receiver operator characteristic curve (ROC) analysis. The Ctrough for teicoplanin showed statistically significant relationships (P<0.05) with PLT, Scr, CLcr, eGFR, BUN and Cys-C. ROC curve analysis revealed that CLcr and eGFR were more sensitive and specific for Ctrough compared to the other factors. These findings should be considered in the clinical application of teicoplanin and for its dosage adjustment. |
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Brazilian Journal of Pharmaceutical Sciences |
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A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infectionsTeicoplanin; HPLC; Therapeutic drug monitoring; Trough concentration; Creatinine clearance; Estimated glomerular filtration rateTeicoplanin is a glycopeptide antibiotic commonly used to treat Gram-positive bacterial infections in the clinic. The aim of this study was to provide a therapeutic reference for the clinical application and dosage regimen adjustment of teicoplanin by identifying factors associated with its plasma trough concentration (Ctrough). A retrospective study was performed on patients with suspected or documented Gram-positive infections who were hospitalized from November 2017 to January 2020 and treated with teicoplanin while undergoing routine therapeutic drug monitoring (TDM). A total of 112 Ctrough trough measurements were obtained from 72 patients were included in this study. SPSS software was used for correlation analysis and receiver operator characteristic curve (ROC) analysis. The Ctrough for teicoplanin showed statistically significant relationships (P<0.05) with PLT, Scr, CLcr, eGFR, BUN and Cys-C. ROC curve analysis revealed that CLcr and eGFR were more sensitive and specific for Ctrough compared to the other factors. These findings should be considered in the clinical application of teicoplanin and for its dosage adjustment.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-04-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/21157410.1590/s2175-97902023e21077Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21077Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21077Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e210772175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/211574/194567https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessLuo Yi-FanWang Yi-DanRen Li-XiangChu Yang2023-05-29T20:55:50Zoai:revistas.usp.br:article/211574Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-29T20:55:50Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections |
title |
A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections |
spellingShingle |
A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections Luo Yi-Fan Teicoplanin; HPLC; Therapeutic drug monitoring; Trough concentration; Creatinine clearance; Estimated glomerular filtration rate |
title_short |
A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections |
title_full |
A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections |
title_fullStr |
A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections |
title_full_unstemmed |
A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections |
title_sort |
A retrospective analysis to estimate trough concentrations of teicoplanin in patients with suspected or documented Gram-positive infections |
author |
Luo Yi-Fan |
author_facet |
Luo Yi-Fan Wang Yi-Dan Ren Li-Xiang Chu Yang |
author_role |
author |
author2 |
Wang Yi-Dan Ren Li-Xiang Chu Yang |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Luo Yi-Fan Wang Yi-Dan Ren Li-Xiang Chu Yang |
dc.subject.por.fl_str_mv |
Teicoplanin; HPLC; Therapeutic drug monitoring; Trough concentration; Creatinine clearance; Estimated glomerular filtration rate |
topic |
Teicoplanin; HPLC; Therapeutic drug monitoring; Trough concentration; Creatinine clearance; Estimated glomerular filtration rate |
description |
Teicoplanin is a glycopeptide antibiotic commonly used to treat Gram-positive bacterial infections in the clinic. The aim of this study was to provide a therapeutic reference for the clinical application and dosage regimen adjustment of teicoplanin by identifying factors associated with its plasma trough concentration (Ctrough). A retrospective study was performed on patients with suspected or documented Gram-positive infections who were hospitalized from November 2017 to January 2020 and treated with teicoplanin while undergoing routine therapeutic drug monitoring (TDM). A total of 112 Ctrough trough measurements were obtained from 72 patients were included in this study. SPSS software was used for correlation analysis and receiver operator characteristic curve (ROC) analysis. The Ctrough for teicoplanin showed statistically significant relationships (P<0.05) with PLT, Scr, CLcr, eGFR, BUN and Cys-C. ROC curve analysis revealed that CLcr and eGFR were more sensitive and specific for Ctrough compared to the other factors. These findings should be considered in the clinical application of teicoplanin and for its dosage adjustment. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211574 10.1590/s2175-97902023e21077 |
url |
https://www.revistas.usp.br/bjps/article/view/211574 |
identifier_str_mv |
10.1590/s2175-97902023e21077 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211574/194567 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21077 Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21077 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21077 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222918021480448 |