Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
DOI: | 10.1590/s2175-97902022e20243 |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/205444 |
Resumo: | In drug therapy, it is important to provide therapeutic levels of drug to the site of action and maintain them during the treatment. This work describes the in vitro release of alendronate from sodium alginate cross-linked Montmorillonite (MMT) composite beads. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of alendronate were studied. Beads were characterized using equilibrium swelling ability study, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Energy-dispersive x-ray spectroscopy (EDX) and scanning electron microscopy (SEM). Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly. |
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oai:revistas.usp.br:article/205444 |
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USP-31 |
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Brazilian Journal of Pharmaceutical Sciences |
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Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked MontmorilloniteAlendronate SodiumSodium alginateDrug deliveryMontmorilloniteIn drug therapy, it is important to provide therapeutic levels of drug to the site of action and maintain them during the treatment. This work describes the in vitro release of alendronate from sodium alginate cross-linked Montmorillonite (MMT) composite beads. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of alendronate were studied. Beads were characterized using equilibrium swelling ability study, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Energy-dispersive x-ray spectroscopy (EDX) and scanning electron microscopy (SEM). Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2022-12-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20544410.1590/s2175-97902022e20243Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/205444/197157Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessShabanpour, SakinehPajoum Shariati, FarshidBagheri Khatibani, Abbas2023-08-11T19:47:13Zoai:revistas.usp.br:article/205444Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-08-11T19:47:13Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite |
title |
Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite |
spellingShingle |
Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite Shabanpour, Sakineh Alendronate Sodium Sodium alginate Drug delivery Montmorillonite Shabanpour, Sakineh Alendronate Sodium Sodium alginate Drug delivery Montmorillonite |
title_short |
Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite |
title_full |
Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite |
title_fullStr |
Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite |
title_full_unstemmed |
Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite |
title_sort |
Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite |
author |
Shabanpour, Sakineh |
author_facet |
Shabanpour, Sakineh Shabanpour, Sakineh Pajoum Shariati, Farshid Bagheri Khatibani, Abbas Pajoum Shariati, Farshid Bagheri Khatibani, Abbas |
author_role |
author |
author2 |
Pajoum Shariati, Farshid Bagheri Khatibani, Abbas |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Shabanpour, Sakineh Pajoum Shariati, Farshid Bagheri Khatibani, Abbas |
dc.subject.por.fl_str_mv |
Alendronate Sodium Sodium alginate Drug delivery Montmorillonite |
topic |
Alendronate Sodium Sodium alginate Drug delivery Montmorillonite |
description |
In drug therapy, it is important to provide therapeutic levels of drug to the site of action and maintain them during the treatment. This work describes the in vitro release of alendronate from sodium alginate cross-linked Montmorillonite (MMT) composite beads. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of alendronate were studied. Beads were characterized using equilibrium swelling ability study, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Energy-dispersive x-ray spectroscopy (EDX) and scanning electron microscopy (SEM). Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-23 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/205444 10.1590/s2175-97902022e20243 |
url |
https://www.revistas.usp.br/bjps/article/view/205444 |
identifier_str_mv |
10.1590/s2175-97902022e20243 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/205444/197157 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1822179249725898752 |
dc.identifier.doi.none.fl_str_mv |
10.1590/s2175-97902022e20243 |