Process optimization of physicochemical properties of spray-dried Hydrocotyle umbellata L. extract

• Autor(a) principal: Matheus Gabriel de Oliveira
• Data de Publicação: 2023
• Outros Autores: Guilherme Gomes Moreira, Andressa Tuane Santana Paz, Thiago Levi Silva Oliveira, Luís Antônio Dantas Silva, Edemilson Cardoso da Conceição, Leonardo Luiz Borges, Vinicius Barreto da Silva, José Realino de Paula
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Pharmaceutical Sciences
• Texto Completo: https://www.revistas.usp.br/bjps/article/view/213815
• topic: Anxiety; Medicinal plants; Phytotherapy; Powder properties; Spray drying

Hydrocotyle umbellata L., Araliaceae, is a species that is recommended in Ayurvedic medicine for its effects on the central nervous system, such as anxiolytic and memory-stimulant effects. Despite the medicinal potential of this species, its phytopharmaceutical and technological potential to produce standardized extracts has not been investigated. This study analyzes the influence of spray drying parameters on the contents of the chemical markers (total phenolic, total flavonoid, and hibalactone) and the functional properties of H. umbellata extract. The optimization of drying conditions was performed using a central composite design combined with response surface methodology and desirability function approach. The mathematical models fitted to experimental data indicated that all the evaluated drying parameters significantly influenced the chemical contents. The optimal conditions were: inlet temperature of 120 °C, feed flow rate of 4 mL min-1, and colloidal silicon dioxide:maltodextrin ratio of 16%:4%. Under these conditions, the powder samples had spherical particles and desirable physicochemical and functional properties, such as low water activity and moisture content, good product recovery, reconstitution, and flowability. Thus, spray drying might be a promising technique for processing standardized H. umbellata extracts.