Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/164855 |
Resumo: | The purpose of the present investigation is to assess, for the first time, the antidiabetic, antihyperlipidemic and antioxidant activities of Lycium europaeum extract in alloxan-induced diabetic rats. Diabetes was induced in adult male Wistar rats via a single subcutaneous alloxan injection (120 mg/kg). Lycium europaeum aqueous extract was orally administered at a dose of 20 mg/kg for 28 consecutive days. Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were assayed at the end of the experimental period in all investigated groups. Antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were sought in the serum and pancreas. Lycium europaeum extract significantly increased HDL-C and reduced blood glucose, TC, LDL-C and TG as compared to the alloxan-control group. Lycium europaeum extract was also efficient in reducing oxidative stress in diabetic rats by increasing SOD, CAT and GPx activities both in the pancreas and the plasma of the animals. Moreover, Lycium europaeum extract contained considerable levels of polyphenols and flavonoids. It also exhibited an important antioxidant capacity and a remarkable ability to quench DPPH radicals and reduce irons. The obtained results highlight potentially relevant health beneficial effects of Lycium europaeum extract, reversing hyperglycemic, hyperlipidemic and oxidative stress effects in rats with alloxan-induced diabetes. Therefore, it may be considered as a promising alternative or complementary agent to diabetes treatment. |
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oai:revistas.usp.br:article/164855 |
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USP-31 |
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Brazilian Journal of Pharmaceutical Sciences |
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Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effectsLycium europaeum/extract/antihyperglycemiaLycium europaeum/extract/antioxidant activityLycium europaeum/extract/antihyperlipidemiaThe purpose of the present investigation is to assess, for the first time, the antidiabetic, antihyperlipidemic and antioxidant activities of Lycium europaeum extract in alloxan-induced diabetic rats. Diabetes was induced in adult male Wistar rats via a single subcutaneous alloxan injection (120 mg/kg). Lycium europaeum aqueous extract was orally administered at a dose of 20 mg/kg for 28 consecutive days. Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were assayed at the end of the experimental period in all investigated groups. Antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were sought in the serum and pancreas. Lycium europaeum extract significantly increased HDL-C and reduced blood glucose, TC, LDL-C and TG as compared to the alloxan-control group. Lycium europaeum extract was also efficient in reducing oxidative stress in diabetic rats by increasing SOD, CAT and GPx activities both in the pancreas and the plasma of the animals. Moreover, Lycium europaeum extract contained considerable levels of polyphenols and flavonoids. It also exhibited an important antioxidant capacity and a remarkable ability to quench DPPH radicals and reduce irons. The obtained results highlight potentially relevant health beneficial effects of Lycium europaeum extract, reversing hyperglycemic, hyperlipidemic and oxidative stress effects in rats with alloxan-induced diabetes. Therefore, it may be considered as a promising alternative or complementary agent to diabetes treatment.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2019-12-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/16485510.1590/s2175-97902019000118064Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18064Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18064Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e180642175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/164855/158014Copyright (c) 2019 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessTej, RabebHamdi, AmelBeji, Raja SerairiWanne, Wissem AidiRebey, Iness BettaiebOueslati, SamiaKsouri, RiadhTounsi, Moufida SaidaniLachaal, MokhtarBouraoui, Najoua Karray2019-12-06T18:54:18Zoai:revistas.usp.br:article/164855Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2019-12-06T18:54:18Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects |
title |
Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects |
spellingShingle |
Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects Tej, Rabeb Lycium europaeum/extract/antihyperglycemia Lycium europaeum/extract/antioxidant activity Lycium europaeum/extract/antihyperlipidemia |
title_short |
Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects |
title_full |
Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects |
title_fullStr |
Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects |
title_full_unstemmed |
Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects |
title_sort |
Does Lycium europaeum leaf have antihyperglycemic, antihyperlipidemic and antioxidant effects |
author |
Tej, Rabeb |
author_facet |
Tej, Rabeb Hamdi, Amel Beji, Raja Serairi Wanne, Wissem Aidi Rebey, Iness Bettaieb Oueslati, Samia Ksouri, Riadh Tounsi, Moufida Saidani Lachaal, Mokhtar Bouraoui, Najoua Karray |
author_role |
author |
author2 |
Hamdi, Amel Beji, Raja Serairi Wanne, Wissem Aidi Rebey, Iness Bettaieb Oueslati, Samia Ksouri, Riadh Tounsi, Moufida Saidani Lachaal, Mokhtar Bouraoui, Najoua Karray |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Tej, Rabeb Hamdi, Amel Beji, Raja Serairi Wanne, Wissem Aidi Rebey, Iness Bettaieb Oueslati, Samia Ksouri, Riadh Tounsi, Moufida Saidani Lachaal, Mokhtar Bouraoui, Najoua Karray |
dc.subject.por.fl_str_mv |
Lycium europaeum/extract/antihyperglycemia Lycium europaeum/extract/antioxidant activity Lycium europaeum/extract/antihyperlipidemia |
topic |
Lycium europaeum/extract/antihyperglycemia Lycium europaeum/extract/antioxidant activity Lycium europaeum/extract/antihyperlipidemia |
description |
The purpose of the present investigation is to assess, for the first time, the antidiabetic, antihyperlipidemic and antioxidant activities of Lycium europaeum extract in alloxan-induced diabetic rats. Diabetes was induced in adult male Wistar rats via a single subcutaneous alloxan injection (120 mg/kg). Lycium europaeum aqueous extract was orally administered at a dose of 20 mg/kg for 28 consecutive days. Serum concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) were assayed at the end of the experimental period in all investigated groups. Antioxidant enzymes such as glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) were sought in the serum and pancreas. Lycium europaeum extract significantly increased HDL-C and reduced blood glucose, TC, LDL-C and TG as compared to the alloxan-control group. Lycium europaeum extract was also efficient in reducing oxidative stress in diabetic rats by increasing SOD, CAT and GPx activities both in the pancreas and the plasma of the animals. Moreover, Lycium europaeum extract contained considerable levels of polyphenols and flavonoids. It also exhibited an important antioxidant capacity and a remarkable ability to quench DPPH radicals and reduce irons. The obtained results highlight potentially relevant health beneficial effects of Lycium europaeum extract, reversing hyperglycemic, hyperlipidemic and oxidative stress effects in rats with alloxan-induced diabetes. Therefore, it may be considered as a promising alternative or complementary agent to diabetes treatment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-06 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164855 10.1590/s2175-97902019000118064 |
url |
https://www.revistas.usp.br/bjps/article/view/164855 |
identifier_str_mv |
10.1590/s2175-97902019000118064 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/164855/158014 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Brazilian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18064 Brazilian Journal of Pharmaceutical Sciences; v. 55 (2019); e18064 Brazilian Journal of Pharmaceutical Sciences; Vol. 55 (2019); e18064 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1787713371911487488 |