In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/153779 |
Resumo: | Griseofulvin (GF) and terbinafine (TF) are commonly used drugs to treat dermatophytosis, a fungal infection of the skin. Today there is an increase in drug resistance to these antifungals which highlight the need for alternative synergistic therapies. Minimum Inhibitory Concentration (MIC) of GF and TF were determined against fungi clinical isolates from local hospitals with values ranging 0.03−2.0 µg mL-1 and 0.24−4.0 µg mL-1, respectively. A checkboard test was used to determine the combination of GF:TF which could induce an additive effect against the fungi isolates Multidrug-resistant isolates showed susceptibility after treatment with 16:2 µg mL-1 GF:TF. An MTT assay further verified that GF and TF combinations have greater additive effect against pathological and multidrug-resistant isolates than antifungals alone. Herein we disclose GF:TF combinations that could constitute as a possible new anti-dermatophyte therapy. |
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Brazilian Journal of Pharmaceutical Sciences |
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In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytesGriseofulvinTerbinafineDermatophyteMultidrug-resistant fungiDrug combinationGriseofulvin (GF) and terbinafine (TF) are commonly used drugs to treat dermatophytosis, a fungal infection of the skin. Today there is an increase in drug resistance to these antifungals which highlight the need for alternative synergistic therapies. Minimum Inhibitory Concentration (MIC) of GF and TF were determined against fungi clinical isolates from local hospitals with values ranging 0.03−2.0 µg mL-1 and 0.24−4.0 µg mL-1, respectively. A checkboard test was used to determine the combination of GF:TF which could induce an additive effect against the fungi isolates Multidrug-resistant isolates showed susceptibility after treatment with 16:2 µg mL-1 GF:TF. An MTT assay further verified that GF and TF combinations have greater additive effect against pathological and multidrug-resistant isolates than antifungals alone. Herein we disclose GF:TF combinations that could constitute as a possible new anti-dermatophyte therapy.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2018-07-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/15377910.1590/s2175-97902018000217149Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17149Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17149Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e171492175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/153779/150170Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessLana, Aline Jacobi DallaPippi, BrunaCarvalho, Anderson RamosMoraes, Renata CougoKaiser, SamuelOrtega, George GonzalezFuentefria, Alexandre MeneghelloSilveira, Gustavo Pozza2019-03-17T13:34:17Zoai:revistas.usp.br:article/153779Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2019-03-17T13:34:17Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes |
title |
In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes |
spellingShingle |
In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes Lana, Aline Jacobi Dalla Griseofulvin Terbinafine Dermatophyte Multidrug-resistant fungi Drug combination |
title_short |
In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes |
title_full |
In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes |
title_fullStr |
In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes |
title_full_unstemmed |
In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes |
title_sort |
In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes |
author |
Lana, Aline Jacobi Dalla |
author_facet |
Lana, Aline Jacobi Dalla Pippi, Bruna Carvalho, Anderson Ramos Moraes, Renata Cougo Kaiser, Samuel Ortega, George Gonzalez Fuentefria, Alexandre Meneghello Silveira, Gustavo Pozza |
author_role |
author |
author2 |
Pippi, Bruna Carvalho, Anderson Ramos Moraes, Renata Cougo Kaiser, Samuel Ortega, George Gonzalez Fuentefria, Alexandre Meneghello Silveira, Gustavo Pozza |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Lana, Aline Jacobi Dalla Pippi, Bruna Carvalho, Anderson Ramos Moraes, Renata Cougo Kaiser, Samuel Ortega, George Gonzalez Fuentefria, Alexandre Meneghello Silveira, Gustavo Pozza |
dc.subject.por.fl_str_mv |
Griseofulvin Terbinafine Dermatophyte Multidrug-resistant fungi Drug combination |
topic |
Griseofulvin Terbinafine Dermatophyte Multidrug-resistant fungi Drug combination |
description |
Griseofulvin (GF) and terbinafine (TF) are commonly used drugs to treat dermatophytosis, a fungal infection of the skin. Today there is an increase in drug resistance to these antifungals which highlight the need for alternative synergistic therapies. Minimum Inhibitory Concentration (MIC) of GF and TF were determined against fungi clinical isolates from local hospitals with values ranging 0.03−2.0 µg mL-1 and 0.24−4.0 µg mL-1, respectively. A checkboard test was used to determine the combination of GF:TF which could induce an additive effect against the fungi isolates Multidrug-resistant isolates showed susceptibility after treatment with 16:2 µg mL-1 GF:TF. An MTT assay further verified that GF and TF combinations have greater additive effect against pathological and multidrug-resistant isolates than antifungals alone. Herein we disclose GF:TF combinations that could constitute as a possible new anti-dermatophyte therapy. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-07-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/153779 10.1590/s2175-97902018000217149 |
url |
https://www.revistas.usp.br/bjps/article/view/153779 |
identifier_str_mv |
10.1590/s2175-97902018000217149 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/153779/150170 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 2 (2018); e17149 Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 2 (2018); e17149 Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 2 (2018); e17149 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222913700298752 |