Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/211871 |
Resumo: | The innate immune response plays an important role in the pathophysiology of acute respiratory distress syndrome (ARDS); however, no drug has been proven to be beneficial in the management of ARDS. Therefore, the aim of this study was to investigate the effects of using combined sedatives on systemic inflammatory responses in patients with ARDS. A total of 90 patients with ARDS and an intubation time of > 120 h were randomly divided into the propofol group (group P), midazolam group (group M), and combined sedation group (group U). Patients in groups P and M were sedated with propofol and midazolam, respectively, whereas patients in group U were sedated with a combination of propofol, midazolam, and dexmedetomidine. The dosage of sedatives and vasoactive drugs, duration of mechanical ventilation, and incidence of sedative adverse reactions were documented. The dosage of sedatives and vasoactive drugs, as well as the incidence of sedative adverse reactions in group U, was significantly lower than those in groups P and M. Similarly, the duration of mechanical ventilation in group U was significantly shorter than that in groups P and M. Hence, inducing sedation through a combination of multiple drugs can significantly reduce their adverse effects, improve their sedative effect, inhibit systemic inflammatory responses, and improve oxygenation in patients with ARDS. |
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Brazilian Journal of Pharmaceutical Sciences |
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Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndromeAcute respiratory distress syndrome; Combined sedation; Propofol; Midazolam; Dexmedetomidine; CytokinesThe innate immune response plays an important role in the pathophysiology of acute respiratory distress syndrome (ARDS); however, no drug has been proven to be beneficial in the management of ARDS. Therefore, the aim of this study was to investigate the effects of using combined sedatives on systemic inflammatory responses in patients with ARDS. A total of 90 patients with ARDS and an intubation time of > 120 h were randomly divided into the propofol group (group P), midazolam group (group M), and combined sedation group (group U). Patients in groups P and M were sedated with propofol and midazolam, respectively, whereas patients in group U were sedated with a combination of propofol, midazolam, and dexmedetomidine. The dosage of sedatives and vasoactive drugs, duration of mechanical ventilation, and incidence of sedative adverse reactions were documented. The dosage of sedatives and vasoactive drugs, as well as the incidence of sedative adverse reactions in group U, was significantly lower than those in groups P and M. Similarly, the duration of mechanical ventilation in group U was significantly shorter than that in groups P and M. Hence, inducing sedation through a combination of multiple drugs can significantly reduce their adverse effects, improve their sedative effect, inhibit systemic inflammatory responses, and improve oxygenation in patients with ARDS.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2023-04-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/21187110.1590/s2175-97902023e21461Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21461Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21461Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e214612175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/211871/194615https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessNie, XiangbiLou, LiqiongXu, HuiXiong, WeiWang, Zenggeng2023-05-31T19:15:09Zoai:revistas.usp.br:article/211871Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-05-31T19:15:09Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome |
title |
Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome |
spellingShingle |
Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome Nie, Xiangbi Acute respiratory distress syndrome; Combined sedation; Propofol; Midazolam; Dexmedetomidine; Cytokines |
title_short |
Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome |
title_full |
Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome |
title_fullStr |
Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome |
title_full_unstemmed |
Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome |
title_sort |
Effect of combined sedation using multiple drugs on inflammatory cytokines in patients with acute respiratory distress syndrome |
author |
Nie, Xiangbi |
author_facet |
Nie, Xiangbi Lou, Liqiong Xu, Hui Xiong, Wei Wang, Zenggeng |
author_role |
author |
author2 |
Lou, Liqiong Xu, Hui Xiong, Wei Wang, Zenggeng |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Nie, Xiangbi Lou, Liqiong Xu, Hui Xiong, Wei Wang, Zenggeng |
dc.subject.por.fl_str_mv |
Acute respiratory distress syndrome; Combined sedation; Propofol; Midazolam; Dexmedetomidine; Cytokines |
topic |
Acute respiratory distress syndrome; Combined sedation; Propofol; Midazolam; Dexmedetomidine; Cytokines |
description |
The innate immune response plays an important role in the pathophysiology of acute respiratory distress syndrome (ARDS); however, no drug has been proven to be beneficial in the management of ARDS. Therefore, the aim of this study was to investigate the effects of using combined sedatives on systemic inflammatory responses in patients with ARDS. A total of 90 patients with ARDS and an intubation time of > 120 h were randomly divided into the propofol group (group P), midazolam group (group M), and combined sedation group (group U). Patients in groups P and M were sedated with propofol and midazolam, respectively, whereas patients in group U were sedated with a combination of propofol, midazolam, and dexmedetomidine. The dosage of sedatives and vasoactive drugs, duration of mechanical ventilation, and incidence of sedative adverse reactions were documented. The dosage of sedatives and vasoactive drugs, as well as the incidence of sedative adverse reactions in group U, was significantly lower than those in groups P and M. Similarly, the duration of mechanical ventilation in group U was significantly shorter than that in groups P and M. Hence, inducing sedation through a combination of multiple drugs can significantly reduce their adverse effects, improve their sedative effect, inhibit systemic inflammatory responses, and improve oxygenation in patients with ARDS. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-04-28 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211871 10.1590/s2175-97902023e21461 |
url |
https://www.revistas.usp.br/bjps/article/view/211871 |
identifier_str_mv |
10.1590/s2175-97902023e21461 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/211871/194615 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21461 Brazilian Journal of Pharmaceutical Sciences; v. 59 (2023); e21461 Brazilian Journal of Pharmaceutical Sciences; Vol. 59 (2023); e21461 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222918040354816 |