Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers

Detalhes bibliográficos
Autor(a) principal: Fernandes, Amanda Velinna
Data de Publicação: 2020
Outros Autores: Pydi, Chinna Raja, Verma, Ruchi, Jose, Jobin, Kumar, Lalit
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Pharmaceutical Sciences
Texto Completo: https://www.revistas.usp.br/bjps/article/view/181435
Resumo: Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.
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spelling Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriersFluconazoleNLCsNanostructured lipid carriersFungal infectionsFull factorial designDesign of experimentPresent study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2020-12-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/18143510.1590/s2175-97902019000318069Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18069Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18069Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e180692175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/181435/168370Copyright (c) 2020 Brazilian Journal of Pharmaceutical Scienceshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFernandes, Amanda Velinna Pydi, Chinna Raja Verma, Ruchi Jose, Jobin Kumar, Lalit 2021-06-12T19:46:54Zoai:revistas.usp.br:article/181435Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2021-06-12T19:46:54Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
title Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
spellingShingle Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
Fernandes, Amanda Velinna
Fluconazole
NLCs
Nanostructured lipid carriers
Fungal infections
Full factorial design
Design of experiment
title_short Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
title_full Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
title_fullStr Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
title_full_unstemmed Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
title_sort Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
author Fernandes, Amanda Velinna
author_facet Fernandes, Amanda Velinna
Pydi, Chinna Raja
Verma, Ruchi
Jose, Jobin
Kumar, Lalit
author_role author
author2 Pydi, Chinna Raja
Verma, Ruchi
Jose, Jobin
Kumar, Lalit
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Amanda Velinna
Pydi, Chinna Raja
Verma, Ruchi
Jose, Jobin
Kumar, Lalit
dc.subject.por.fl_str_mv Fluconazole
NLCs
Nanostructured lipid carriers
Fungal infections
Full factorial design
Design of experiment
topic Fluconazole
NLCs
Nanostructured lipid carriers
Fungal infections
Full factorial design
Design of experiment
description Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjps/article/view/181435
10.1590/s2175-97902019000318069
url https://www.revistas.usp.br/bjps/article/view/181435
identifier_str_mv 10.1590/s2175-97902019000318069
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjps/article/view/181435/168370
dc.rights.driver.fl_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18069
Brazilian Journal of Pharmaceutical Sciences; v. 56 (2020); e18069
Brazilian Journal of Pharmaceutical Sciences; Vol. 56 (2020); e18069
2175-9790
1984-8250
reponame:Brazilian Journal of Pharmaceutical Sciences
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Pharmaceutical Sciences
collection Brazilian Journal of Pharmaceutical Sciences
repository.name.fl_str_mv Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)
repository.mail.fl_str_mv bjps@usp.br||elizabeth.igne@gmail.com
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