Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/128380 |
Resumo: | Skin aging causes changes such as wrinkles and flaccidity leading to a large demand for aesthetic procedures, including dermal filling. A key agent in dermal filling is hyaluronic acid (HA), which is a naturally occurring glycosaminoglycan. However, it is a hydrophilic macromolecule that experiences great difficulty in crossing the skin barrier causing most commercial formulations containing it to be injectable, which in turn brings risks since they involve an invasive technique. In that sense, the aim of this study was to develop and characterize nanoparticles obtained from ionic interaction between HA and lysine (Lys) for use as a potential agent of dermal filling for topical application, increasing and improving its applicability and safety. To this end, nanoparticles were obtained by dripping of Lys over HA under magnetic stirring. A nanometric size was confirmed and a suitable surface charge was obtained by zeta potential. Nanoparticles were almost spherical in shape with a smooth surface. Interaction between raw materials for preparing nanoparticles was studied by FTIR and NMR spectroscopy and an ionic interaction was confirmed. These physicochemical features suggest that obtained nanoparticles can be further used as a topical dermal filling. |
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Brazilian Journal of Pharmaceutical Sciences |
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Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling Skin aging causes changes such as wrinkles and flaccidity leading to a large demand for aesthetic procedures, including dermal filling. A key agent in dermal filling is hyaluronic acid (HA), which is a naturally occurring glycosaminoglycan. However, it is a hydrophilic macromolecule that experiences great difficulty in crossing the skin barrier causing most commercial formulations containing it to be injectable, which in turn brings risks since they involve an invasive technique. In that sense, the aim of this study was to develop and characterize nanoparticles obtained from ionic interaction between HA and lysine (Lys) for use as a potential agent of dermal filling for topical application, increasing and improving its applicability and safety. To this end, nanoparticles were obtained by dripping of Lys over HA under magnetic stirring. A nanometric size was confirmed and a suitable surface charge was obtained by zeta potential. Nanoparticles were almost spherical in shape with a smooth surface. Interaction between raw materials for preparing nanoparticles was studied by FTIR and NMR spectroscopy and an ionic interaction was confirmed. These physicochemical features suggest that obtained nanoparticles can be further used as a topical dermal filling. Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2016-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/12838010.1590/s1984-82502016000400008Brazilian Journal of Pharmaceutical Sciences; Vol. 52 Núm. 4 (2016); 645-651Brazilian Journal of Pharmaceutical Sciences; v. 52 n. 4 (2016); 645-651Brazilian Journal of Pharmaceutical Sciences; Vol. 52 No. 4 (2016); 645-6512175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/128380/125253Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso)info:eu-repo/semantics/openAccessCarneiro, JaquelineDöll-Boscardin, Patrícia MathiasFiorin, Bárbara CelâniaNadal, Jessica MendesFarago, Paulo VitorPaula, Josiane Padilha de2017-03-16T18:09:44Zoai:revistas.usp.br:article/128380Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2017-03-16T18:09:44Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling |
title |
Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling |
spellingShingle |
Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling Carneiro, Jaqueline |
title_short |
Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling |
title_full |
Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling |
title_fullStr |
Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling |
title_full_unstemmed |
Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling |
title_sort |
Development and characterization of hyaluronic acid-lysine nanoparticles with potential as innovative dermal filling |
author |
Carneiro, Jaqueline |
author_facet |
Carneiro, Jaqueline Döll-Boscardin, Patrícia Mathias Fiorin, Bárbara Celânia Nadal, Jessica Mendes Farago, Paulo Vitor Paula, Josiane Padilha de |
author_role |
author |
author2 |
Döll-Boscardin, Patrícia Mathias Fiorin, Bárbara Celânia Nadal, Jessica Mendes Farago, Paulo Vitor Paula, Josiane Padilha de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Carneiro, Jaqueline Döll-Boscardin, Patrícia Mathias Fiorin, Bárbara Celânia Nadal, Jessica Mendes Farago, Paulo Vitor Paula, Josiane Padilha de |
description |
Skin aging causes changes such as wrinkles and flaccidity leading to a large demand for aesthetic procedures, including dermal filling. A key agent in dermal filling is hyaluronic acid (HA), which is a naturally occurring glycosaminoglycan. However, it is a hydrophilic macromolecule that experiences great difficulty in crossing the skin barrier causing most commercial formulations containing it to be injectable, which in turn brings risks since they involve an invasive technique. In that sense, the aim of this study was to develop and characterize nanoparticles obtained from ionic interaction between HA and lysine (Lys) for use as a potential agent of dermal filling for topical application, increasing and improving its applicability and safety. To this end, nanoparticles were obtained by dripping of Lys over HA under magnetic stirring. A nanometric size was confirmed and a suitable surface charge was obtained by zeta potential. Nanoparticles were almost spherical in shape with a smooth surface. Interaction between raw materials for preparing nanoparticles was studied by FTIR and NMR spectroscopy and an ionic interaction was confirmed. These physicochemical features suggest that obtained nanoparticles can be further used as a topical dermal filling. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/128380 10.1590/s1984-82502016000400008 |
url |
https://www.revistas.usp.br/bjps/article/view/128380 |
identifier_str_mv |
10.1590/s1984-82502016000400008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/128380/125253 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Brazilian Journal of Pharmaceutical Sciences (Impresso) |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 52 Núm. 4 (2016); 645-651 Brazilian Journal of Pharmaceutical Sciences; v. 52 n. 4 (2016); 645-651 Brazilian Journal of Pharmaceutical Sciences; Vol. 52 No. 4 (2016); 645-651 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222912863535104 |