Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Pharmaceutical Sciences |
Texto Completo: | https://www.revistas.usp.br/bjps/article/view/206126 |
Resumo: | Hepatoprotective effects of many herbal agents have been reported in animal studies and clinical trials. In this study, five hepatoprotective plants with potent antioxidant, anti-inflammatory, and hypolipidemic effects were chosen to prepare a polyherbal compound for managing NAFLD. Sixty patients with NAFLD were randomly divided into treatment and control groups (2:1 ratio). Both group were advised to take healthy diet and exercise. The treatment group also received herbal capsules containing 400 mg of the mixture of Anethum graveolens, Citrus aurantium, Cynara scolymus, Portulaca oleracea, and Silybum marianum (2 capsules, thrice daily, for two months). The liver ultrasound and biochemical markers including the serum lipids, liver enzymes, and glucose were evaluated before starting the study and at the end of the treatment. Thirty patients in the treatment group and sixteen patients in the control group completed the study. The herbal compound significantly decreased the serum level of alanine transaminase (ALT), aspartate transaminase (AST), and total cholesterol. Treatment with the herbal compound significantly improved the grade of the fatty liver, but no significant change was found in the control group. In conclusion, the formulated herbal compound appeared to be effective in biochemical improvement and decreasing the grade of the fatty liver in the patients with NAFLD. |
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Brazilian Journal of Pharmaceutical Sciences |
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Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver diseaseAnethum graveolens CitrusCynara scolymusFatty liverPortulaca oleraceaSilybum marianumHepatoprotective effects of many herbal agents have been reported in animal studies and clinical trials. In this study, five hepatoprotective plants with potent antioxidant, anti-inflammatory, and hypolipidemic effects were chosen to prepare a polyherbal compound for managing NAFLD. Sixty patients with NAFLD were randomly divided into treatment and control groups (2:1 ratio). Both group were advised to take healthy diet and exercise. The treatment group also received herbal capsules containing 400 mg of the mixture of Anethum graveolens, Citrus aurantium, Cynara scolymus, Portulaca oleracea, and Silybum marianum (2 capsules, thrice daily, for two months). The liver ultrasound and biochemical markers including the serum lipids, liver enzymes, and glucose were evaluated before starting the study and at the end of the treatment. Thirty patients in the treatment group and sixteen patients in the control group completed the study. The herbal compound significantly decreased the serum level of alanine transaminase (ALT), aspartate transaminase (AST), and total cholesterol. Treatment with the herbal compound significantly improved the grade of the fatty liver, but no significant change was found in the control group. In conclusion, the formulated herbal compound appeared to be effective in biochemical improvement and decreasing the grade of the fatty liver in the patients with NAFLD.Universidade de São Paulo. Faculdade de Ciências Farmacêuticas2022-12-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjps/article/view/20612610.1590/s2175-97902022e18825Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022)Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022)2175-97901984-8250reponame:Brazilian Journal of Pharmaceutical Sciencesinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/bjps/article/view/206126/196199Copyright (c) 2022 Brazilian Journal of Pharmaceutical Scienceshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAbbas Zojaji, SeyyedMosannen Mozaffari, HoomanGhaderi, PouyaZojaji, FaeghehZojaji, FaeghehHadjzadeh, Mousa-Al-RezaSeyfimoqadam, MonirehGhorbani, Ahmad2023-08-21T19:15:58Zoai:revistas.usp.br:article/206126Revistahttps://www.revistas.usp.br/bjps/indexPUBhttps://old.scielo.br/oai/scielo-oai.phpbjps@usp.br||elizabeth.igne@gmail.com2175-97901984-8250opendoar:2023-08-21T19:15:58Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease |
title |
Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease |
spellingShingle |
Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease Abbas Zojaji, Seyyed Anethum graveolens Citrus Cynara scolymus Fatty liver Portulaca oleracea Silybum marianum |
title_short |
Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease |
title_full |
Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease |
title_fullStr |
Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease |
title_full_unstemmed |
Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease |
title_sort |
Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease: Efficacy of an herbal compound in decreasing steatosis and transaminase activities in non-alcoholic fatty liver disease |
author |
Abbas Zojaji, Seyyed |
author_facet |
Abbas Zojaji, Seyyed Mosannen Mozaffari, Hooman Ghaderi, Pouya Zojaji, Faegheh Hadjzadeh, Mousa-Al-Reza Seyfimoqadam, Monireh Ghorbani, Ahmad |
author_role |
author |
author2 |
Mosannen Mozaffari, Hooman Ghaderi, Pouya Zojaji, Faegheh Hadjzadeh, Mousa-Al-Reza Seyfimoqadam, Monireh Ghorbani, Ahmad |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Abbas Zojaji, Seyyed Mosannen Mozaffari, Hooman Ghaderi, Pouya Zojaji, Faegheh Zojaji, Faegheh Hadjzadeh, Mousa-Al-Reza Seyfimoqadam, Monireh Ghorbani, Ahmad |
dc.subject.por.fl_str_mv |
Anethum graveolens Citrus Cynara scolymus Fatty liver Portulaca oleracea Silybum marianum |
topic |
Anethum graveolens Citrus Cynara scolymus Fatty liver Portulaca oleracea Silybum marianum |
description |
Hepatoprotective effects of many herbal agents have been reported in animal studies and clinical trials. In this study, five hepatoprotective plants with potent antioxidant, anti-inflammatory, and hypolipidemic effects were chosen to prepare a polyherbal compound for managing NAFLD. Sixty patients with NAFLD were randomly divided into treatment and control groups (2:1 ratio). Both group were advised to take healthy diet and exercise. The treatment group also received herbal capsules containing 400 mg of the mixture of Anethum graveolens, Citrus aurantium, Cynara scolymus, Portulaca oleracea, and Silybum marianum (2 capsules, thrice daily, for two months). The liver ultrasound and biochemical markers including the serum lipids, liver enzymes, and glucose were evaluated before starting the study and at the end of the treatment. Thirty patients in the treatment group and sixteen patients in the control group completed the study. The herbal compound significantly decreased the serum level of alanine transaminase (ALT), aspartate transaminase (AST), and total cholesterol. Treatment with the herbal compound significantly improved the grade of the fatty liver, but no significant change was found in the control group. In conclusion, the formulated herbal compound appeared to be effective in biochemical improvement and decreasing the grade of the fatty liver in the patients with NAFLD. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/206126 10.1590/s2175-97902022e18825 |
url |
https://www.revistas.usp.br/bjps/article/view/206126 |
identifier_str_mv |
10.1590/s2175-97902022e18825 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjps/article/view/206126/196199 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Pharmaceutical Sciences https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; v. 58 (2022) Brazilian Journal of Pharmaceutical Sciences; Vol. 58 (2022) 2175-9790 1984-8250 reponame:Brazilian Journal of Pharmaceutical Sciences instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Pharmaceutical Sciences |
collection |
Brazilian Journal of Pharmaceutical Sciences |
repository.name.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
bjps@usp.br||elizabeth.igne@gmail.com |
_version_ |
1800222917054693376 |