The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone

Detalhes bibliográficos
Autor(a) principal: Moraes, Julieta Rodini Engrácia de
Data de Publicação: 1996
Outros Autores: Moraes, Flávio Ruas de, Bechara, Gervásio Henrique
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Veterinary Research and Animal Science
Texto Completo: https://www.revistas.usp.br/bjvras/article/view/50271
Resumo: The effect of indomethacin and dexamethasone on PMN cell migration was studied in relation to chloramphenicol in the pleural cavity of rats, 4 hours after local injection of carrageenin or dextran. Pre-treatment of rats with chloramphenicol succinate (30mg/kg), ip, every 12h, during 4 days, potentiated the migration of PMN leucocytes to the inflamed cavity, when carrageenin (150mcg) was used as an irritant. However, responses to dextran (100mcg) remained the same. Chloramphenicol pre-treated rats that received indomethacin (2mg/kg, per os, 30min before carrageenin) or dexamethasone (0.25mg/kg, ip, 30min before carrageenin) showed inhibition of potentiated cellular responses. Mechanisms of the potentiating effect of chloramphenicol on the acute carrageenin-induced inflammation remains unclear.
id USP-49_0885532acf8aa7f5dc2fcccf0de41063
oai_identifier_str oai:revistas.usp.br:article/50271
network_acronym_str USP-49
network_name_str Brazilian Journal of Veterinary Research and Animal Science
repository_id_str https://www.revistas.usp.br/bjvras/index
spelling The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone0 efeito potenciador do succinato de cloranfenicol sobre a pleurisia aguda induzida pela carragenina. Inibição por indometacina e dexametasonaCloranfenicolPleurisiaCarrageninaDextranoIndometacinaDexametasona.ChloramphenicolPleurisyCarrageeninDextranIndomethacinDexamethasone.The effect of indomethacin and dexamethasone on PMN cell migration was studied in relation to chloramphenicol in the pleural cavity of rats, 4 hours after local injection of carrageenin or dextran. Pre-treatment of rats with chloramphenicol succinate (30mg/kg), ip, every 12h, during 4 days, potentiated the migration of PMN leucocytes to the inflamed cavity, when carrageenin (150mcg) was used as an irritant. However, responses to dextran (100mcg) remained the same. Chloramphenicol pre-treated rats that received indomethacin (2mg/kg, per os, 30min before carrageenin) or dexamethasone (0.25mg/kg, ip, 30min before carrageenin) showed inhibition of potentiated cellular responses. Mechanisms of the potentiating effect of chloramphenicol on the acute carrageenin-induced inflammation remains unclear.Neste trabalho estudaram-se os efeitos da indometacina e dexametasona sobre a migração das células polimorfonucleares (PMN), produzida pelo cloranfenicol 4h após a aplicação intrapleural de carragenina ou dextrano. Demonstrou-se que o pré-tratamento de ratos com cloranfenicol (30mg/kg, ip, a cada 12h, por 4 dias) potenciou a migração de PMN para a cavidade inflamada, quando a carragenina (150mg) foi utilizada como estímulo inflamatório, enquanto a resposta ao dextrano (100mcg) não se alterou, em comparação com animais não tratados com o antibiótico. Ratos que receberam cloranfenicol e foram tratados com indometacina (2,0mg/kg, per os, 30 min antes da aplicação de carragenina) ou dexametasona (0,25mg/kg, ip, 30 min antes da aplicação de carragenina) apresentaram inibição das respostas celulares potenciadas. O mecanismo pelo qual o cloranfenicol produz aumento da resposta inflamatória permanece obscuro.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia1996-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/5027110.11606/issn.2318-3659.v33i1p11-14Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 Núm. 1 (1996); 11-14Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 No. 1 (1996); 11-14Brazilian Journal of Veterinary Research and Animal Science; v. 33 n. 1 (1996); 11-14Brazilian Journal of Veterinary Research and Animal Science; V. 33 N. 1 (1996); 11-141678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPenghttps://www.revistas.usp.br/bjvras/article/view/50271/54384Moraes, Julieta Rodini Engrácia deMoraes, Flávio Ruas deBechara, Gervásio Henriqueinfo:eu-repo/semantics/openAccess2020-06-23T04:50:35Zoai:revistas.usp.br:article/50271Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:43:17.560458Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false
dc.title.none.fl_str_mv The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone
0 efeito potenciador do succinato de cloranfenicol sobre a pleurisia aguda induzida pela carragenina. Inibição por indometacina e dexametasona
title The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone
spellingShingle The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone
Moraes, Julieta Rodini Engrácia de
Cloranfenicol
Pleurisia
Carragenina
Dextrano
Indometacina
Dexametasona.
Chloramphenicol
Pleurisy
Carrageenin
Dextran
Indomethacin
Dexamethasone.
title_short The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone
title_full The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone
title_fullStr The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone
title_full_unstemmed The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone
title_sort The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone
author Moraes, Julieta Rodini Engrácia de
author_facet Moraes, Julieta Rodini Engrácia de
Moraes, Flávio Ruas de
Bechara, Gervásio Henrique
author_role author
author2 Moraes, Flávio Ruas de
Bechara, Gervásio Henrique
author2_role author
author
dc.contributor.author.fl_str_mv Moraes, Julieta Rodini Engrácia de
Moraes, Flávio Ruas de
Bechara, Gervásio Henrique
dc.subject.por.fl_str_mv Cloranfenicol
Pleurisia
Carragenina
Dextrano
Indometacina
Dexametasona.
Chloramphenicol
Pleurisy
Carrageenin
Dextran
Indomethacin
Dexamethasone.
topic Cloranfenicol
Pleurisia
Carragenina
Dextrano
Indometacina
Dexametasona.
Chloramphenicol
Pleurisy
Carrageenin
Dextran
Indomethacin
Dexamethasone.
description The effect of indomethacin and dexamethasone on PMN cell migration was studied in relation to chloramphenicol in the pleural cavity of rats, 4 hours after local injection of carrageenin or dextran. Pre-treatment of rats with chloramphenicol succinate (30mg/kg), ip, every 12h, during 4 days, potentiated the migration of PMN leucocytes to the inflamed cavity, when carrageenin (150mcg) was used as an irritant. However, responses to dextran (100mcg) remained the same. Chloramphenicol pre-treated rats that received indomethacin (2mg/kg, per os, 30min before carrageenin) or dexamethasone (0.25mg/kg, ip, 30min before carrageenin) showed inhibition of potentiated cellular responses. Mechanisms of the potentiating effect of chloramphenicol on the acute carrageenin-induced inflammation remains unclear.
publishDate 1996
dc.date.none.fl_str_mv 1996-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/50271
10.11606/issn.2318-3659.v33i1p11-14
url https://www.revistas.usp.br/bjvras/article/view/50271
identifier_str_mv 10.11606/issn.2318-3659.v33i1p11-14
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/50271/54384
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 Núm. 1 (1996); 11-14
Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 No. 1 (1996); 11-14
Brazilian Journal of Veterinary Research and Animal Science; v. 33 n. 1 (1996); 11-14
Brazilian Journal of Veterinary Research and Animal Science; V. 33 N. 1 (1996); 11-14
1678-4456
1413-9596
reponame:Brazilian Journal of Veterinary Research and Animal Science
instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron:USP
instname_str Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Veterinary Research and Animal Science
collection Brazilian Journal of Veterinary Research and Animal Science
repository.name.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
repository.mail.fl_str_mv bjvras@usp.br
_version_ 1797051562696114176

Registros relacionados