Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticos
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Research and Animal Science |
Texto Completo: | https://www.revistas.usp.br/bjvras/article/view/5673 |
Resumo: | We investigated the effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the reduced polymorphonuclear leukocytes (PMN) accumulation in carrageenin-induced pleurisy (150 mug) in diabetic (alloxan, 40 mg/kg, IV) rats (Wistar, males, 180-320 g, n = 12). Chloramphenicol produced an increase (p<0.05) on PMN count in pleural exudate of 36% in normal animals. In the animals non-treated with chloramphenicol the diabetes state reduced (p<0.05) the accumulation of PMN cells by 45%. In diabetic animals treated with chloramphenicol the number of PMN in pleural exudate was similar to the one observed in the control group. Total and differential counts of leukocytes in the peripheral blood were similar between groups before and 4 h after the carrageenin-injection. |
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Brazilian Journal of Veterinary Research and Animal Science |
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Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticosChloramphenicol restores the polymorphonuclear accumulation in carrageenin-induced pleurisy in diabetic ratsCloranfenicolDiabetesPleurisiaNeutrófilosChloramphenicolDiabetesPleurisiaNeutrophilsWe investigated the effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the reduced polymorphonuclear leukocytes (PMN) accumulation in carrageenin-induced pleurisy (150 mug) in diabetic (alloxan, 40 mg/kg, IV) rats (Wistar, males, 180-320 g, n = 12). Chloramphenicol produced an increase (p<0.05) on PMN count in pleural exudate of 36% in normal animals. In the animals non-treated with chloramphenicol the diabetes state reduced (p<0.05) the accumulation of PMN cells by 45%. In diabetic animals treated with chloramphenicol the number of PMN in pleural exudate was similar to the one observed in the control group. Total and differential counts of leukocytes in the peripheral blood were similar between groups before and 4 h after the carrageenin-injection.Investigou-se o efeito do succinato de cloranfenicol (30 mg/kg, a cada 12 h, durante 4 dias, IP) sobre o acúmulo de leucócitos polimorfonucleares (PMN) na pleurisia induzida pela carragenina (150 mig) em ratos (Wistar, machos, 180-230 g, n = 12) diabéticos (40 mg/kg de aloxana, IV). O antibiótico produziu aumento de 36% no número de PMN (p<0,05) migrados para a cavidade pleural de animais normais. O estado diabético provocou redução de 45% dos PMN (p<0,05) acumulados no exsudato pleural de animais não tratados com o antibiótico. Por outro lado, animais diabéticos tratados com succinato de cloranfenicol apresentaram resposta de PMN que não diferiu estatisticamente do observado em animais controle, não tratados. A contagem total e diferencial dos leucócitos circulantes realizada antes e 4 h depois da aplicação da carragenina não diferiu estatisticamente entre os grupos.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia1998-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/567310.1590/S1413-95961998000600002Brazilian Journal of Veterinary Research and Animal Science; Vol. 35 Núm. 6 (1998); 243-245Brazilian Journal of Veterinary Research and Animal Science; Vol. 35 No. 6 (1998); 243-245Brazilian Journal of Veterinary Research and Animal Science; v. 35 n. 6 (1998); 243-245Brazilian Journal of Veterinary Research and Animal Science; V. 35 N. 6 (1998); 243-2451678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPenghttps://www.revistas.usp.br/bjvras/article/view/5673/7204Moraes, Julieta Rodini Engrácia deMoraes, Flávio Ruas deEngrácia Filho, Jair Rodiniinfo:eu-repo/semantics/openAccess2020-06-23T04:46:28Zoai:revistas.usp.br:article/5673Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:42:16.603016Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false |
dc.title.none.fl_str_mv |
Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticos Chloramphenicol restores the polymorphonuclear accumulation in carrageenin-induced pleurisy in diabetic rats |
title |
Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticos |
spellingShingle |
Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticos Moraes, Julieta Rodini Engrácia de Cloranfenicol Diabetes Pleurisia Neutrófilos Chloramphenicol Diabetes Pleurisia Neutrophils |
title_short |
Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticos |
title_full |
Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticos |
title_fullStr |
Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticos |
title_full_unstemmed |
Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticos |
title_sort |
Succinato de cloranfenicol restaura o acúmulo de células polimorfonucleares na pleurisia induzida pela carragenina em ratos diabéticos |
author |
Moraes, Julieta Rodini Engrácia de |
author_facet |
Moraes, Julieta Rodini Engrácia de Moraes, Flávio Ruas de Engrácia Filho, Jair Rodini |
author_role |
author |
author2 |
Moraes, Flávio Ruas de Engrácia Filho, Jair Rodini |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Moraes, Julieta Rodini Engrácia de Moraes, Flávio Ruas de Engrácia Filho, Jair Rodini |
dc.subject.por.fl_str_mv |
Cloranfenicol Diabetes Pleurisia Neutrófilos Chloramphenicol Diabetes Pleurisia Neutrophils |
topic |
Cloranfenicol Diabetes Pleurisia Neutrófilos Chloramphenicol Diabetes Pleurisia Neutrophils |
description |
We investigated the effect of chloramphenicol succinate (30 mg/kg, every 12 h for 4 days, ip) on the reduced polymorphonuclear leukocytes (PMN) accumulation in carrageenin-induced pleurisy (150 mug) in diabetic (alloxan, 40 mg/kg, IV) rats (Wistar, males, 180-320 g, n = 12). Chloramphenicol produced an increase (p<0.05) on PMN count in pleural exudate of 36% in normal animals. In the animals non-treated with chloramphenicol the diabetes state reduced (p<0.05) the accumulation of PMN cells by 45%. In diabetic animals treated with chloramphenicol the number of PMN in pleural exudate was similar to the one observed in the control group. Total and differential counts of leukocytes in the peripheral blood were similar between groups before and 4 h after the carrageenin-injection. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/5673 10.1590/S1413-95961998000600002 |
url |
https://www.revistas.usp.br/bjvras/article/view/5673 |
identifier_str_mv |
10.1590/S1413-95961998000600002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/5673/7204 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 35 Núm. 6 (1998); 243-245 Brazilian Journal of Veterinary Research and Animal Science; Vol. 35 No. 6 (1998); 243-245 Brazilian Journal of Veterinary Research and Animal Science; v. 35 n. 6 (1998); 243-245 Brazilian Journal of Veterinary Research and Animal Science; V. 35 N. 6 (1998); 243-245 1678-4456 1413-9596 reponame:Brazilian Journal of Veterinary Research and Animal Science instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) instacron:USP |
instname_str |
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Veterinary Research and Animal Science |
collection |
Brazilian Journal of Veterinary Research and Animal Science |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
repository.mail.fl_str_mv |
bjvras@usp.br |
_version_ |
1797051554174337024 |