Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Research and Animal Science |
Texto Completo: | https://www.revistas.usp.br/bjvras/article/view/191527 |
Resumo: | In breast cancer treatment, chemotherapy resistance is a major problem where many receptive tumors rebound and develop resistance. When provided in combination, cancer drugs are most successful, thus reducing the risk of developing resistant cancer cells. However, the evaluation of combination therapies has increased rapidly in recent years. Consequently, by repurposing old treatments, the discovery of additional medicines that may interact synergistically with chemotherapy is considered a current medical aim through discovering a new cancer medication or therapeutic strategy. The purpose of this research is to increase the anti-cancer activity of carboplatin (CP) by increasing the apoptotic effect of breast cancer cells (MCF-7) during in vitro experiments in combination with oxytetracycline. Our results showed a high synergistic effect between oxytetracycline and carboplatin, MCF-7 representative cell treated with carboplatin with/without different concentrations of oxytetracycline (5% and 10% of IC50). Oxytetracycline, which potentiated the action of carboplatin and/or had notable activity was reported as a single agent. This research demonstrated the synergistic relationship between oxytetracycline and carboplatin in viability assays. Surprisingly, our findings suggest that inhibiting treatment strategies can extend carboplatin’s therapeutic window, potentially allowing for cancer therapy. |
id |
USP-49_43a1c3e6fd78c8de47d84bb251644ca3 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/191527 |
network_acronym_str |
USP-49 |
network_name_str |
Brazilian Journal of Veterinary Research and Animal Science |
repository_id_str |
https://www.revistas.usp.br/bjvras/index |
spelling |
Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell lineEfeito sinérgico da oxitetraciclina em um tratamento combinado com Carboplatina na linhagem de células cancerígenas pulmonares MCF-7CarboplatinaOxitetracilinaCélulas de câncer pulmonar (MCF-7)Ensaio in vitroQuimioterapiaCarboplatinOxytetracyclineBreast cancer cells (MCF-7)In vitro assayChemotherapyIn breast cancer treatment, chemotherapy resistance is a major problem where many receptive tumors rebound and develop resistance. When provided in combination, cancer drugs are most successful, thus reducing the risk of developing resistant cancer cells. However, the evaluation of combination therapies has increased rapidly in recent years. Consequently, by repurposing old treatments, the discovery of additional medicines that may interact synergistically with chemotherapy is considered a current medical aim through discovering a new cancer medication or therapeutic strategy. The purpose of this research is to increase the anti-cancer activity of carboplatin (CP) by increasing the apoptotic effect of breast cancer cells (MCF-7) during in vitro experiments in combination with oxytetracycline. Our results showed a high synergistic effect between oxytetracycline and carboplatin, MCF-7 representative cell treated with carboplatin with/without different concentrations of oxytetracycline (5% and 10% of IC50). Oxytetracycline, which potentiated the action of carboplatin and/or had notable activity was reported as a single agent. This research demonstrated the synergistic relationship between oxytetracycline and carboplatin in viability assays. Surprisingly, our findings suggest that inhibiting treatment strategies can extend carboplatin’s therapeutic window, potentially allowing for cancer therapy.No tratamento do câncer de pulmão a resistência à quimioterapia é o maior problema no qual muitos tumores receptivos apresentam um rebote e desenvolvem a resistência. Quando oferecidas em combinações, as drogas anticancerígenas apresentam maior taxa de sucesso, reduzindo assim o risco de desenvolvimento de células cancerígenas resistentes. Contudo, a avaliação das terapias de combinação tem crescido muito rapidamente. Consequentemente, por reaproveitamento de tratamentos antigos, a descoberta de novos medicamentos adicionais que podem interagir sinergicamente com a quimioterapia que é considerada como auxílio médico na corrente busca à descoberta de novas medicações anticancerígenas ou estratégias terapêuticas. O propósito da presente pesquisa é aumentar a atividade anticancerígena da Carboplatina (CP) pelo incremento do efeito apoptótico de células de câncer pulmonar (MCF-7) em experimentos in vitro pela combinação com oxitetraciclina. Os resultados obtidos confirmaram elevado efeito sinérgico entre oxitetraciclina e Carboplatina em células MCF-7 representativas tratadas com Carboplatina, com e sem diferentes concentrações de oxitetraciclina (5% e 10% de IC50). A oxitetracilina que potencializou a ação da Carboplatina e/ou teve uma notável atividade relatada como um agente isolado. A pesquisa demonstrou a relação sinérgica entre oxitetraxiclina e Carboplatina nos ensaios de viabilidade. Surpreendentemente, os resultados obtidos sugeriram que as estratégias de tratamento inibidor podem aplicar uma janela terapêutica da Carboplatina com potencial para a terapia do câncer.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2022-10-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/19152710.11606/issn.1678-4456.bjvras.2022.191527Brazilian Journal of Veterinary Research and Animal Science; Vol. 59 (2022); e191527Brazilian Journal of Veterinary Research and Animal Science; Vol. 59 (2022); e191527Brazilian Journal of Veterinary Research and Animal Science; v. 59 (2022); e191527Brazilian Journal of Veterinary Research and Animal Science; V. 59 (2022); e1915271678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPenghttps://www.revistas.usp.br/bjvras/article/view/191527/187537Copyright (c) 2022 Brazilian Journal of Veterinary Research and Animal Sciencehttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessJabber, Eman JawadAlzayd, Asawer MhammedJawad, Mohammed JasimSulbi, Ihsan MohammedHassan, Saif MohammedJawad, Mahmood JasimJasim, Adnan Mansour2022-03-14T18:39:49Zoai:revistas.usp.br:article/191527Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:44:10.436396Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false |
dc.title.none.fl_str_mv |
Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line Efeito sinérgico da oxitetraciclina em um tratamento combinado com Carboplatina na linhagem de células cancerígenas pulmonares MCF-7 |
title |
Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line |
spellingShingle |
Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line Jabber, Eman Jawad Carboplatina Oxitetracilina Células de câncer pulmonar (MCF-7) Ensaio in vitro Quimioterapia Carboplatin Oxytetracycline Breast cancer cells (MCF-7) In vitro assay Chemotherapy |
title_short |
Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line |
title_full |
Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line |
title_fullStr |
Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line |
title_full_unstemmed |
Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line |
title_sort |
Synergistic effect of oxytetracycline as a combination treatment with Carboplatin on MCF-7 breast cancer cell line |
author |
Jabber, Eman Jawad |
author_facet |
Jabber, Eman Jawad Alzayd, Asawer Mhammed Jawad, Mohammed Jasim Sulbi, Ihsan Mohammed Hassan, Saif Mohammed Jawad, Mahmood Jasim Jasim, Adnan Mansour |
author_role |
author |
author2 |
Alzayd, Asawer Mhammed Jawad, Mohammed Jasim Sulbi, Ihsan Mohammed Hassan, Saif Mohammed Jawad, Mahmood Jasim Jasim, Adnan Mansour |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Jabber, Eman Jawad Alzayd, Asawer Mhammed Jawad, Mohammed Jasim Sulbi, Ihsan Mohammed Hassan, Saif Mohammed Jawad, Mahmood Jasim Jasim, Adnan Mansour |
dc.subject.por.fl_str_mv |
Carboplatina Oxitetracilina Células de câncer pulmonar (MCF-7) Ensaio in vitro Quimioterapia Carboplatin Oxytetracycline Breast cancer cells (MCF-7) In vitro assay Chemotherapy |
topic |
Carboplatina Oxitetracilina Células de câncer pulmonar (MCF-7) Ensaio in vitro Quimioterapia Carboplatin Oxytetracycline Breast cancer cells (MCF-7) In vitro assay Chemotherapy |
description |
In breast cancer treatment, chemotherapy resistance is a major problem where many receptive tumors rebound and develop resistance. When provided in combination, cancer drugs are most successful, thus reducing the risk of developing resistant cancer cells. However, the evaluation of combination therapies has increased rapidly in recent years. Consequently, by repurposing old treatments, the discovery of additional medicines that may interact synergistically with chemotherapy is considered a current medical aim through discovering a new cancer medication or therapeutic strategy. The purpose of this research is to increase the anti-cancer activity of carboplatin (CP) by increasing the apoptotic effect of breast cancer cells (MCF-7) during in vitro experiments in combination with oxytetracycline. Our results showed a high synergistic effect between oxytetracycline and carboplatin, MCF-7 representative cell treated with carboplatin with/without different concentrations of oxytetracycline (5% and 10% of IC50). Oxytetracycline, which potentiated the action of carboplatin and/or had notable activity was reported as a single agent. This research demonstrated the synergistic relationship between oxytetracycline and carboplatin in viability assays. Surprisingly, our findings suggest that inhibiting treatment strategies can extend carboplatin’s therapeutic window, potentially allowing for cancer therapy. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/191527 10.11606/issn.1678-4456.bjvras.2022.191527 |
url |
https://www.revistas.usp.br/bjvras/article/view/191527 |
identifier_str_mv |
10.11606/issn.1678-4456.bjvras.2022.191527 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/191527/187537 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Veterinary Research and Animal Science https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Veterinary Research and Animal Science https://creativecommons.org/licenses/by-nc-sa/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 59 (2022); e191527 Brazilian Journal of Veterinary Research and Animal Science; Vol. 59 (2022); e191527 Brazilian Journal of Veterinary Research and Animal Science; v. 59 (2022); e191527 Brazilian Journal of Veterinary Research and Animal Science; V. 59 (2022); e191527 1678-4456 1413-9596 reponame:Brazilian Journal of Veterinary Research and Animal Science instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) instacron:USP |
instname_str |
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Veterinary Research and Animal Science |
collection |
Brazilian Journal of Veterinary Research and Animal Science |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
repository.mail.fl_str_mv |
bjvras@usp.br |
_version_ |
1797051568360521728 |