Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Veterinary Research and Animal Science |
Texto Completo: | https://www.revistas.usp.br/bjvras/article/view/55822 |
Resumo: | Pyrethroid insecticides are extensively used for pest control around the house, flea prevention for pets, and plant sprays for the home and in agriculture. Deltamethrin (DTM) is a Type II pyrethroid insecticide used to control a variety of insects in agriculture and domestic environments. The present study investigated the possible anxiogenic effects of DTM (1, 3, and 10 mg/kg) in rats using behavioral and neurochemical methods. We assessed general locomotor activity and behavior in the elevated plus maze and open field test. Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) increased striatal serotonin neurotransmitter and its metabolite, and (vii) did not alter motor coordination on the rotarod, grooming duration in the open field test, rectal temperature, or hippocampal neurotransmitter levels. These data suggest that DTM at the present doses and under these experimental conditions presented a similar profile to that of anxiogenic drugs, unrelated with the increased serotonin neurotransmission. |
id |
USP-49_6109dc9da732d2454388801b618813e5 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/55822 |
network_acronym_str |
USP-49 |
network_name_str |
Brazilian Journal of Veterinary Research and Animal Science |
repository_id_str |
https://www.revistas.usp.br/bjvras/index |
spelling |
Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in ratsEvidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratosDeltametrinaPiretróideAnsiedadeComportamentoNeurotransmissores centraisDeltamethrinPyrethroidAnxietyBehaviorCentral neurotransmittersPyrethroid insecticides are extensively used for pest control around the house, flea prevention for pets, and plant sprays for the home and in agriculture. Deltamethrin (DTM) is a Type II pyrethroid insecticide used to control a variety of insects in agriculture and domestic environments. The present study investigated the possible anxiogenic effects of DTM (1, 3, and 10 mg/kg) in rats using behavioral and neurochemical methods. We assessed general locomotor activity and behavior in the elevated plus maze and open field test. Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) increased striatal serotonin neurotransmitter and its metabolite, and (vii) did not alter motor coordination on the rotarod, grooming duration in the open field test, rectal temperature, or hippocampal neurotransmitter levels. These data suggest that DTM at the present doses and under these experimental conditions presented a similar profile to that of anxiogenic drugs, unrelated with the increased serotonin neurotransmission.Inseticidas piretróides são amplamente utilizados para controle de pragas, como na prevenção de pulgas em animais de estimação e sprays de plantas para a casa e na agricultura. Deltametrina (DTM) é um inseticida piretróide tipo II usado para controlar uma variedade de insetos na agricultura e ambientes domésticos. O presente estudo investigou os possíveis efeitos ansiogênicos de DTM (1, 3 e 10 mg/kg) em ratos, utilizando métodos comportamentais e neuroquímicos. Foi avaliada a atividade locomotora geral e comportamento no labirinto em cruz elevado e teste de campo aberto. Os níveis de neurotransmissores e metabólitos no estriado e hipocampo também foram mensurados. DTM (i) reduziu a locomoção e a frequência de levantar, (ii) aumentou da duração da imobilidade, (iii) reduziu o tempo de interação social, (iv) reduziu a percentagem de entradas e tempo gasto nos braços abertos do elevado labirinto em cruz, (v) reduziu o número de cruzamentos no centro do labirinto em cruz elevado, (vi) aumentou neurotransmissor serotonina e de seu metabólito estriatal, e (vii) não alterou a coordenação motora no rotarod, duração do grooming no teste de campo aberto, temperatura retal, ou níveis de neurotransmissores do hipocampo. Estes dados sugerem que DTM nas presentes doses e sob estas condições experimentais apresentaram um perfil semelhante ao de drogas ansiogénicas, não relacionados ao aumento da serotonina estriatal.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2013-02-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/5582210.11606/issn.2318-3659.v50i1p33-42Brazilian Journal of Veterinary Research and Animal Science; Vol. 50 Núm. 1 (2013); 33-42Brazilian Journal of Veterinary Research and Animal Science; Vol. 50 No. 1 (2013); 33-42Brazilian Journal of Veterinary Research and Animal Science; v. 50 n. 1 (2013); 33-42Brazilian Journal of Veterinary Research and Animal Science; V. 50 N. 1 (2013); 33-421678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPenghttps://www.revistas.usp.br/bjvras/article/view/55822/59228Ricci, Esther LopesFerreira Jr, VladimirHabr, Soraya FerreiraMacrini, Daclé JulianiBernardi, Maria MarthaSpinosa, Helenice de Souzainfo:eu-repo/semantics/openAccess2020-06-23T04:07:37Zoai:revistas.usp.br:article/55822Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:43:32.219979Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false |
dc.title.none.fl_str_mv |
Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in rats Evidências neuroquímicas e comportamentais do efeito ansiogênico da deltametrina em ratos |
title |
Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in rats |
spellingShingle |
Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in rats Ricci, Esther Lopes Deltametrina Piretróide Ansiedade Comportamento Neurotransmissores centrais Deltamethrin Pyrethroid Anxiety Behavior Central neurotransmitters |
title_short |
Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in rats |
title_full |
Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in rats |
title_fullStr |
Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in rats |
title_full_unstemmed |
Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in rats |
title_sort |
Behavioral and neurochemical evidence of deltamethrin anxiogenic-like effects in rats |
author |
Ricci, Esther Lopes |
author_facet |
Ricci, Esther Lopes Ferreira Jr, Vladimir Habr, Soraya Ferreira Macrini, Daclé Juliani Bernardi, Maria Martha Spinosa, Helenice de Souza |
author_role |
author |
author2 |
Ferreira Jr, Vladimir Habr, Soraya Ferreira Macrini, Daclé Juliani Bernardi, Maria Martha Spinosa, Helenice de Souza |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ricci, Esther Lopes Ferreira Jr, Vladimir Habr, Soraya Ferreira Macrini, Daclé Juliani Bernardi, Maria Martha Spinosa, Helenice de Souza |
dc.subject.por.fl_str_mv |
Deltametrina Piretróide Ansiedade Comportamento Neurotransmissores centrais Deltamethrin Pyrethroid Anxiety Behavior Central neurotransmitters |
topic |
Deltametrina Piretróide Ansiedade Comportamento Neurotransmissores centrais Deltamethrin Pyrethroid Anxiety Behavior Central neurotransmitters |
description |
Pyrethroid insecticides are extensively used for pest control around the house, flea prevention for pets, and plant sprays for the home and in agriculture. Deltamethrin (DTM) is a Type II pyrethroid insecticide used to control a variety of insects in agriculture and domestic environments. The present study investigated the possible anxiogenic effects of DTM (1, 3, and 10 mg/kg) in rats using behavioral and neurochemical methods. We assessed general locomotor activity and behavior in the elevated plus maze and open field test. Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) Striatal and hippocampal neurotransmitter and metabolite levels were also measured. DTM (i) reduced locomotion and rearing frequency, (ii) slightly increased the duration of immobility, (iii) reduced the time engaged in social interaction, (iv) reduced the percentage of entries into and time spent on the open arms of the elevated plus maze, (v) reduced the number of center crossings in the elevated plus maze, (vi) increased striatal serotonin neurotransmitter and its metabolite, and (vii) did not alter motor coordination on the rotarod, grooming duration in the open field test, rectal temperature, or hippocampal neurotransmitter levels. These data suggest that DTM at the present doses and under these experimental conditions presented a similar profile to that of anxiogenic drugs, unrelated with the increased serotonin neurotransmission. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-02-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/55822 10.11606/issn.2318-3659.v50i1p33-42 |
url |
https://www.revistas.usp.br/bjvras/article/view/55822 |
identifier_str_mv |
10.11606/issn.2318-3659.v50i1p33-42 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/bjvras/article/view/55822/59228 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia |
dc.source.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science; Vol. 50 Núm. 1 (2013); 33-42 Brazilian Journal of Veterinary Research and Animal Science; Vol. 50 No. 1 (2013); 33-42 Brazilian Journal of Veterinary Research and Animal Science; v. 50 n. 1 (2013); 33-42 Brazilian Journal of Veterinary Research and Animal Science; V. 50 N. 1 (2013); 33-42 1678-4456 1413-9596 reponame:Brazilian Journal of Veterinary Research and Animal Science instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) instacron:USP |
instname_str |
Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Brazilian Journal of Veterinary Research and Animal Science |
collection |
Brazilian Journal of Veterinary Research and Animal Science |
repository.name.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP) |
repository.mail.fl_str_mv |
bjvras@usp.br |
_version_ |
1797051564399001600 |