Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins

Detalhes bibliográficos
Autor(a) principal: Weigel, Rebeca Alves
Data de Publicação: 2010
Outros Autores: Ortolani, Enrico Lippi, Sucupira, Maria Claudia Araripe
Tipo de documento: Artigo
Idioma: por
Título da fonte: Brazilian Journal of Veterinary Research and Animal Science
Texto Completo: https://www.revistas.usp.br/bjvras/article/view/26803
Resumo: The effects of vitamins C and/or E associated to amonium tetrathiomolybdate (TTM) in the treatment of cumulative copper intoxication (ICC) in sheep were analyzed throughout oxidative metabolism. Reduced glutathione (GSH), malondialdehyde (MDA), uric acid and the ferric reducing ability of plasma (FRAP) concentrations were evaluated. Twenty four male sheep, Santa Ines breed, with 25 kg BW was distributed in four treatments: TTM, TTM and vitamin C (TTM+VC), TTM with vitamin E (TTM+VE) and TTM with vitamins C and E (TTM+VCE). The intoxication status caused an intensive formation of free radicals with reduction of the GSH concentration and increase of MDA. Despite the increase in the capacity of plasmatic antioxidant observed with the increase of uric acid and FRAP concentrations, it was not observed any benefit with treatments using oxidant vitamins, isolatedly or together with classic treatment only with TTM.
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spelling Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitaminsAvaliação do metabolismo oxidativo de ovinos intoxicados por cobre e tratados com tetratiomolibdato associado ou não a vitaminas antioxidantesVitamina CVitamina EIntoxicação cumulativa por cobreEstresse oxidativoTetratiomolibdato de amônio (TTM)Vitamin CVitamin ECopper cumulative poisoningOxidative StressAmonium tetrathiomolybdate (TTM)The effects of vitamins C and/or E associated to amonium tetrathiomolybdate (TTM) in the treatment of cumulative copper intoxication (ICC) in sheep were analyzed throughout oxidative metabolism. Reduced glutathione (GSH), malondialdehyde (MDA), uric acid and the ferric reducing ability of plasma (FRAP) concentrations were evaluated. Twenty four male sheep, Santa Ines breed, with 25 kg BW was distributed in four treatments: TTM, TTM and vitamin C (TTM+VC), TTM with vitamin E (TTM+VE) and TTM with vitamins C and E (TTM+VCE). The intoxication status caused an intensive formation of free radicals with reduction of the GSH concentration and increase of MDA. Despite the increase in the capacity of plasmatic antioxidant observed with the increase of uric acid and FRAP concentrations, it was not observed any benefit with treatments using oxidant vitamins, isolatedly or together with classic treatment only with TTM.Para avaliar o efeito da utilização parenteral das vitaminas C e/ou E associadas ao quelante de cobre, tetratiomolibdato de amônio (TTM), no tratamento de ovinos com intoxicação cumulativa por cobre (ICC), foram analisados o metabolismo oxidativo, através das concentrações sanguíneas de glutationa reduzida (GSH), séricas de malondialdeído (MDA) e ácido úrico, e a habilidade de redução férrica plasmática (HRFP) desses animais. Foram utilizados 24 ovinos machos, da raça Santa Inês, com peso médio de 25 kg e distribuídos em quatro tratamentos: TTM, TTM e vitamina C (TTM+VC), TTM e vitamina E (TTM+VE) e TTM e vitaminas C e E (TTM+VCE). O quadro de intoxicação cúprica provocou intensa formação de radicais livres, com redução da concentração de GSH e aumento do MDA, apesar do aumento na capacidade antioxidante plasmática, decorrente do aumento da concentração de ácido úrico e da HRFP. Não foi observado benefício algum da utilização das vitaminas antioxidantes, isoladamente ou associadas, com o tratamento clássico baseado na administração de TTM, na redução do estresse oxidativo.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/2680310.11606/issn.1678-4456.bjvras.2010.26803Brazilian Journal of Veterinary Research and Animal Science; Vol. 47 Núm. 6 (2010); 421-428Brazilian Journal of Veterinary Research and Animal Science; Vol. 47 No. 6 (2010); 421-428Brazilian Journal of Veterinary Research and Animal Science; v. 47 n. 6 (2010); 421-428Brazilian Journal of Veterinary Research and Animal Science; V. 47 N. 6 (2010); 421-4281678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPporhttps://www.revistas.usp.br/bjvras/article/view/26803/28586Weigel, Rebeca AlvesOrtolani, Enrico LippiSucupira, Maria Claudia Araripeinfo:eu-repo/semantics/openAccess2020-06-23T04:10:08Zoai:revistas.usp.br:article/26803Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:43:04.824977Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false
dc.title.none.fl_str_mv Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins
Avaliação do metabolismo oxidativo de ovinos intoxicados por cobre e tratados com tetratiomolibdato associado ou não a vitaminas antioxidantes
title Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins
spellingShingle Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins
Weigel, Rebeca Alves
Vitamina C
Vitamina E
Intoxicação cumulativa por cobre
Estresse oxidativo
Tetratiomolibdato de amônio (TTM)
Vitamin C
Vitamin E
Copper cumulative poisoning
Oxidative Stress
Amonium tetrathiomolybdate (TTM)
title_short Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins
title_full Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins
title_fullStr Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins
title_full_unstemmed Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins
title_sort Oxidative metabolism in copper poisoning sheep treated with tetrathiomolybdate and/or antioxidative vitamins
author Weigel, Rebeca Alves
author_facet Weigel, Rebeca Alves
Ortolani, Enrico Lippi
Sucupira, Maria Claudia Araripe
author_role author
author2 Ortolani, Enrico Lippi
Sucupira, Maria Claudia Araripe
author2_role author
author
dc.contributor.author.fl_str_mv Weigel, Rebeca Alves
Ortolani, Enrico Lippi
Sucupira, Maria Claudia Araripe
dc.subject.por.fl_str_mv Vitamina C
Vitamina E
Intoxicação cumulativa por cobre
Estresse oxidativo
Tetratiomolibdato de amônio (TTM)
Vitamin C
Vitamin E
Copper cumulative poisoning
Oxidative Stress
Amonium tetrathiomolybdate (TTM)
topic Vitamina C
Vitamina E
Intoxicação cumulativa por cobre
Estresse oxidativo
Tetratiomolibdato de amônio (TTM)
Vitamin C
Vitamin E
Copper cumulative poisoning
Oxidative Stress
Amonium tetrathiomolybdate (TTM)
description The effects of vitamins C and/or E associated to amonium tetrathiomolybdate (TTM) in the treatment of cumulative copper intoxication (ICC) in sheep were analyzed throughout oxidative metabolism. Reduced glutathione (GSH), malondialdehyde (MDA), uric acid and the ferric reducing ability of plasma (FRAP) concentrations were evaluated. Twenty four male sheep, Santa Ines breed, with 25 kg BW was distributed in four treatments: TTM, TTM and vitamin C (TTM+VC), TTM with vitamin E (TTM+VE) and TTM with vitamins C and E (TTM+VCE). The intoxication status caused an intensive formation of free radicals with reduction of the GSH concentration and increase of MDA. Despite the increase in the capacity of plasmatic antioxidant observed with the increase of uric acid and FRAP concentrations, it was not observed any benefit with treatments using oxidant vitamins, isolatedly or together with classic treatment only with TTM.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/26803
10.11606/issn.1678-4456.bjvras.2010.26803
url https://www.revistas.usp.br/bjvras/article/view/26803
identifier_str_mv 10.11606/issn.1678-4456.bjvras.2010.26803
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/26803/28586
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science; Vol. 47 Núm. 6 (2010); 421-428
Brazilian Journal of Veterinary Research and Animal Science; Vol. 47 No. 6 (2010); 421-428
Brazilian Journal of Veterinary Research and Animal Science; v. 47 n. 6 (2010); 421-428
Brazilian Journal of Veterinary Research and Animal Science; V. 47 N. 6 (2010); 421-428
1678-4456
1413-9596
reponame:Brazilian Journal of Veterinary Research and Animal Science
instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron:USP
instname_str Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Veterinary Research and Animal Science
collection Brazilian Journal of Veterinary Research and Animal Science
repository.name.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
repository.mail.fl_str_mv bjvras@usp.br
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