Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5

Detalhes bibliográficos
Autor(a) principal: Ferreira Neto, José Soares
Data de Publicação: 1996
Outros Autores: Pinheiro, Sonia Regina, Moraes, Zenaide Maria, Rocha, Luiz Carlos Sá, Sinhorini, Idércio Luiz, Ito, Fumio Homma, Vasconcellos, Silvio Arruda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Veterinary Research and Animal Science
Texto Completo: https://www.revistas.usp.br/bjvras/article/view/50183
Resumo: The evolution of disease by intraperitoneal inoculation of Mycobacterium bovis (strain AN5) was evaluated in hamsters (Mesocricetus auratus) treated daily, from Monday to Friday, with 30 mg/kg of Trichlorfon given subcutaneously, for a period of 8 consecutive weeks. The criteria used for the evaluation were post infection survival time and quantitative cultures of mycobacteria from spleen, kidney, liver and lung taken at 1, 15, 29 and 45 days after inoculation.Histopathologic examinations were also performed at each scheduled time. Treated and control animals developed progressive disease. The results of quantitative cultures and survival time after inoculation were not influenced byTrichlorfon as related to the evolution of tuberculosis.
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spelling Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5Avaliação quantitativa da evolução da tuberculose em hamsters tratados 8 semanas consecutivas com Triclorfon e infectados com Mycobacterium bovis, cepa AN5HamstersMycobacterium bovis-Triclorfon.HamstersMycobacterium bovisTrichlorfon.The evolution of disease by intraperitoneal inoculation of Mycobacterium bovis (strain AN5) was evaluated in hamsters (Mesocricetus auratus) treated daily, from Monday to Friday, with 30 mg/kg of Trichlorfon given subcutaneously, for a period of 8 consecutive weeks. The criteria used for the evaluation were post infection survival time and quantitative cultures of mycobacteria from spleen, kidney, liver and lung taken at 1, 15, 29 and 45 days after inoculation.Histopathologic examinations were also performed at each scheduled time. Treated and control animals developed progressive disease. The results of quantitative cultures and survival time after inoculation were not influenced byTrichlorfon as related to the evolution of tuberculosis.A evolução da doença causada pela inoculação intraperitoneal de Mycobacterium bovis (cepa AN5) foi avaliada em hamsters (Mesocrícetus auratus) tratados de segundas a sextas-feiras, com doses subcutâneas de 30 mg/kg de Triclorfon, por um período de 8 semanas consecutivas. Os critérios adotados para essa avaliação foram o tempo de sobrevivência após ainoculação e a quantificação do agente no baço, fígado, rim e pulmão colhidos aos 1, 15, 29 e 45 dias após a inoculação. Nessas oportunidades também foram realizados exames histopatológicos. Os animais do grupo tratado com Triclorfon e do grupo controle desenvolveram tuberculose progressiva. Os resultados da quantificação do agente nos órgãos examinados, e do tempo de sobrevivência após a inoculação, não mostraram qualquer influência da administração do Triclorfon.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia1996-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/bjvras/article/view/5018310.11606/issn.2318-3659.v33i3p139-143Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 Núm. 3 (1996); 139-143Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 No. 3 (1996); 139-143Brazilian Journal of Veterinary Research and Animal Science; v. 33 n. 3 (1996); 139-143Brazilian Journal of Veterinary Research and Animal Science; V. 33 N. 3 (1996); 139-1431678-44561413-9596reponame:Brazilian Journal of Veterinary Research and Animal Scienceinstname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)instacron:USPenghttps://www.revistas.usp.br/bjvras/article/view/50183/54298Ferreira Neto, José SoaresPinheiro, Sonia ReginaMoraes, Zenaide MariaRocha, Luiz Carlos SáSinhorini, Idércio LuizIto, Fumio HommaVasconcellos, Silvio Arrudainfo:eu-repo/semantics/openAccess2020-06-23T04:49:51Zoai:revistas.usp.br:article/50183Revistahttps://www.revistas.usp.br/bjvrasPUBhttps://www.revistas.usp.br/bjvras/oaibjvras@usp.br1413-95961413-9596opendoar:https://www.revistas.usp.br/bjvras/index2023-01-12T16:43:14.985573Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)false
dc.title.none.fl_str_mv Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5
Avaliação quantitativa da evolução da tuberculose em hamsters tratados 8 semanas consecutivas com Triclorfon e infectados com Mycobacterium bovis, cepa AN5
title Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5
spellingShingle Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5
Ferreira Neto, José Soares
Hamsters
Mycobacterium bovis-
Triclorfon.
Hamsters
Mycobacterium bovis
Trichlorfon.
title_short Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5
title_full Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5
title_fullStr Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5
title_full_unstemmed Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5
title_sort Quantitative evaluation of tuberculosis evolution in hamsters submitted to an eight-week Trichlorfon treatment and infected with Mycobacterium bovis, strain AN5
author Ferreira Neto, José Soares
author_facet Ferreira Neto, José Soares
Pinheiro, Sonia Regina
Moraes, Zenaide Maria
Rocha, Luiz Carlos Sá
Sinhorini, Idércio Luiz
Ito, Fumio Homma
Vasconcellos, Silvio Arruda
author_role author
author2 Pinheiro, Sonia Regina
Moraes, Zenaide Maria
Rocha, Luiz Carlos Sá
Sinhorini, Idércio Luiz
Ito, Fumio Homma
Vasconcellos, Silvio Arruda
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira Neto, José Soares
Pinheiro, Sonia Regina
Moraes, Zenaide Maria
Rocha, Luiz Carlos Sá
Sinhorini, Idércio Luiz
Ito, Fumio Homma
Vasconcellos, Silvio Arruda
dc.subject.por.fl_str_mv Hamsters
Mycobacterium bovis-
Triclorfon.
Hamsters
Mycobacterium bovis
Trichlorfon.
topic Hamsters
Mycobacterium bovis-
Triclorfon.
Hamsters
Mycobacterium bovis
Trichlorfon.
description The evolution of disease by intraperitoneal inoculation of Mycobacterium bovis (strain AN5) was evaluated in hamsters (Mesocricetus auratus) treated daily, from Monday to Friday, with 30 mg/kg of Trichlorfon given subcutaneously, for a period of 8 consecutive weeks. The criteria used for the evaluation were post infection survival time and quantitative cultures of mycobacteria from spleen, kidney, liver and lung taken at 1, 15, 29 and 45 days after inoculation.Histopathologic examinations were also performed at each scheduled time. Treated and control animals developed progressive disease. The results of quantitative cultures and survival time after inoculation were not influenced byTrichlorfon as related to the evolution of tuberculosis.
publishDate 1996
dc.date.none.fl_str_mv 1996-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/50183
10.11606/issn.2318-3659.v33i3p139-143
url https://www.revistas.usp.br/bjvras/article/view/50183
identifier_str_mv 10.11606/issn.2318-3659.v33i3p139-143
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/bjvras/article/view/50183/54298
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 Núm. 3 (1996); 139-143
Brazilian Journal of Veterinary Research and Animal Science; Vol. 33 No. 3 (1996); 139-143
Brazilian Journal of Veterinary Research and Animal Science; v. 33 n. 3 (1996); 139-143
Brazilian Journal of Veterinary Research and Animal Science; V. 33 N. 3 (1996); 139-143
1678-4456
1413-9596
reponame:Brazilian Journal of Veterinary Research and Animal Science
instname:Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron:USP
instname_str Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
instacron_str USP
institution USP
reponame_str Brazilian Journal of Veterinary Research and Animal Science
collection Brazilian Journal of Veterinary Research and Animal Science
repository.name.fl_str_mv Brazilian Journal of Veterinary Research and Animal Science - Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP)
repository.mail.fl_str_mv bjvras@usp.br
_version_ 1797051562571333632

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