Pathophysiology of cancer cachexia

Detalhes bibliográficos
Autor(a) principal: Younes,Riad N.
Data de Publicação: 2000
Outros Autores: Noguchi,Yoshikazu
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Hospital das Clínicas
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812000000500005
Resumo: Cancer cachexia is a frequent complication observed in patients with malignant tumors. Although several decades have passed since the first focus on the metabolic dysfunction's associated with cancer, few effective therapeutic interventions have been successfully introduced into the medical armamentarium. The present study thoroughly reviews the basic pathophysiology of cancer cachexia and the treatment options already investigated in that field. Experimental and clinical studies were evaluated individually in order to clarify the intricate alterations observed in tumor-bearing patients. The difficulties in introducing sound and effective nutritional support or metabolic manipulation to reverse cancer cachexia are outlined in this review.
id USP-57_220d7f98fcc81bbfa6d4f0f5b6fd552b
oai_identifier_str oai:scielo:S0041-87812000000500005
network_acronym_str USP-57
network_name_str Revista do Hospital das Clínicas
repository_id_str
spelling Pathophysiology of cancer cachexiaCancerCachexiaMetabolismCytokineInsulinCancer cachexia is a frequent complication observed in patients with malignant tumors. Although several decades have passed since the first focus on the metabolic dysfunction's associated with cancer, few effective therapeutic interventions have been successfully introduced into the medical armamentarium. The present study thoroughly reviews the basic pathophysiology of cancer cachexia and the treatment options already investigated in that field. Experimental and clinical studies were evaluated individually in order to clarify the intricate alterations observed in tumor-bearing patients. The difficulties in introducing sound and effective nutritional support or metabolic manipulation to reverse cancer cachexia are outlined in this review.Faculdade de Medicina / Universidade de São Paulo - FM/USP2000-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812000000500005Revista do Hospital das Clínicas v.55 n.5 2000reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87812000000500005info:eu-repo/semantics/openAccessYounes,Riad N.Noguchi,Yoshikazueng2001-01-11T00:00:00Zoai:scielo:S0041-87812000000500005Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2001-01-11T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Pathophysiology of cancer cachexia
title Pathophysiology of cancer cachexia
spellingShingle Pathophysiology of cancer cachexia
Younes,Riad N.
Cancer
Cachexia
Metabolism
Cytokine
Insulin
title_short Pathophysiology of cancer cachexia
title_full Pathophysiology of cancer cachexia
title_fullStr Pathophysiology of cancer cachexia
title_full_unstemmed Pathophysiology of cancer cachexia
title_sort Pathophysiology of cancer cachexia
author Younes,Riad N.
author_facet Younes,Riad N.
Noguchi,Yoshikazu
author_role author
author2 Noguchi,Yoshikazu
author2_role author
dc.contributor.author.fl_str_mv Younes,Riad N.
Noguchi,Yoshikazu
dc.subject.por.fl_str_mv Cancer
Cachexia
Metabolism
Cytokine
Insulin
topic Cancer
Cachexia
Metabolism
Cytokine
Insulin
description Cancer cachexia is a frequent complication observed in patients with malignant tumors. Although several decades have passed since the first focus on the metabolic dysfunction's associated with cancer, few effective therapeutic interventions have been successfully introduced into the medical armamentarium. The present study thoroughly reviews the basic pathophysiology of cancer cachexia and the treatment options already investigated in that field. Experimental and clinical studies were evaluated individually in order to clarify the intricate alterations observed in tumor-bearing patients. The difficulties in introducing sound and effective nutritional support or metabolic manipulation to reverse cancer cachexia are outlined in this review.
publishDate 2000
dc.date.none.fl_str_mv 2000-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812000000500005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812000000500005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0041-87812000000500005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
publisher.none.fl_str_mv Faculdade de Medicina / Universidade de São Paulo - FM/USP
dc.source.none.fl_str_mv Revista do Hospital das Clínicas v.55 n.5 2000
reponame:Revista do Hospital das Clínicas
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista do Hospital das Clínicas
collection Revista do Hospital das Clínicas
repository.name.fl_str_mv Revista do Hospital das Clínicas - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||revista.hc@hcnet.usp.br
_version_ 1754820894059921408

Registros relacionados