The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women

Detalhes bibliográficos
Autor(a) principal: Keshavarz, Sedigheh
Data de Publicação: 2020
Outros Autores: Morshed-Behbahani, Bahar, Parsanezhad, Mohammad Ebrahim, Ghanizadeh, Ahmad, Sayadi, Mehrap, Akbarzadeh, Marzieh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Archives of Clinical Psychiatry
Texto Completo: https://www.revistas.usp.br/acp/article/view/168071
Resumo: Objectives: This study aimed to explore the effect of antidepressant treatment on the HPA axis, changes in depression score, and serum levels of TNF-α in depressed infertile women. Methods: In this randomized controlled trial research, 60 infertile women who had undergone in vitro fertilization (IVF) treatment with depression scores between 16-47 were divided into two groups. The intervention group with fluoxetine capsule was under treatment for two months before the embryo transfer, while the control group was given placebo. Depression score, serum levels of tumor necrosis factor alpha (TNF-α) as well as cortisol hormone levels were measured and recorded both before and after the intervention. The data were analyzed using SPSS version 21 software. Results: We analyzed the data related to 55 subjects who had undergone embryo transfer. 7 subjects in the intervention group and 3 in the control group got pregnant. We observed a significant decrease in the depression score (p < 0/001) and serum levels of cortisol (p = 0/001) in the intervention group. There was a significant increase in the serum levels of TNF-α in the intervention group (p < 0/001). There was a significant difference between the two groups in the number of pregnancies (p = 0.04). However, there was no statistical difference between them with regard to the number of harvested oocytes (p = 0.174). Discussion: Decrease in depression score and cortisol level, and an increase in the levels of TNF-α in the intervention group caused any changes in the number of oocytes in comparison with the control group. However, the number of pregnancies was larger in the intervention group.
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spelling The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile womenTNF-αinfertilitydepressionHPA axistreatmentObjectives: This study aimed to explore the effect of antidepressant treatment on the HPA axis, changes in depression score, and serum levels of TNF-α in depressed infertile women. Methods: In this randomized controlled trial research, 60 infertile women who had undergone in vitro fertilization (IVF) treatment with depression scores between 16-47 were divided into two groups. The intervention group with fluoxetine capsule was under treatment for two months before the embryo transfer, while the control group was given placebo. Depression score, serum levels of tumor necrosis factor alpha (TNF-α) as well as cortisol hormone levels were measured and recorded both before and after the intervention. The data were analyzed using SPSS version 21 software. Results: We analyzed the data related to 55 subjects who had undergone embryo transfer. 7 subjects in the intervention group and 3 in the control group got pregnant. We observed a significant decrease in the depression score (p < 0/001) and serum levels of cortisol (p = 0/001) in the intervention group. There was a significant increase in the serum levels of TNF-α in the intervention group (p < 0/001). There was a significant difference between the two groups in the number of pregnancies (p = 0.04). However, there was no statistical difference between them with regard to the number of harvested oocytes (p = 0.174). Discussion: Decrease in depression score and cortisol level, and an increase in the levels of TNF-α in the intervention group caused any changes in the number of oocytes in comparison with the control group. However, the number of pregnancies was larger in the intervention group.Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria2020-03-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/acp/article/view/16807110.1590/0101-60830000000222Archives of Clinical Psychiatry; v. 47 n. 1 (2020); 7-12Archives of Clinical Psychiatry; Vol. 47 No. 1 (2020); 7-12Revista de Psiquiatria Clínica; Vol. 47 Núm. 1 (2020); 7-121806-938X0101-6083reponame:Archives of Clinical Psychiatryinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/acp/article/view/168071/160037Copyright (c) 2020 Archives of Clinical Psychiatryinfo:eu-repo/semantics/openAccessKeshavarz, SedighehMorshed-Behbahani, BaharParsanezhad, Mohammad EbrahimGhanizadeh, AhmadSayadi, MehrapAkbarzadeh, Marzieh2021-02-18T20:01:08Zoai:revistas.usp.br:article/168071Revistahttp://www.hcnet.usp.br/ipq/revista/index.htmlPUBhttps://old.scielo.br/oai/scielo-oai.php||archives@usp.br1806-938X0101-6083opendoar:2021-02-18T20:01:08Archives of Clinical Psychiatry - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women
title The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women
spellingShingle The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women
Keshavarz, Sedigheh
TNF-α
infertility
depression
HPA axis
treatment
title_short The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women
title_full The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women
title_fullStr The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women
title_full_unstemmed The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women
title_sort The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women
author Keshavarz, Sedigheh
author_facet Keshavarz, Sedigheh
Morshed-Behbahani, Bahar
Parsanezhad, Mohammad Ebrahim
Ghanizadeh, Ahmad
Sayadi, Mehrap
Akbarzadeh, Marzieh
author_role author
author2 Morshed-Behbahani, Bahar
Parsanezhad, Mohammad Ebrahim
Ghanizadeh, Ahmad
Sayadi, Mehrap
Akbarzadeh, Marzieh
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Keshavarz, Sedigheh
Morshed-Behbahani, Bahar
Parsanezhad, Mohammad Ebrahim
Ghanizadeh, Ahmad
Sayadi, Mehrap
Akbarzadeh, Marzieh
dc.subject.por.fl_str_mv TNF-α
infertility
depression
HPA axis
treatment
topic TNF-α
infertility
depression
HPA axis
treatment
description Objectives: This study aimed to explore the effect of antidepressant treatment on the HPA axis, changes in depression score, and serum levels of TNF-α in depressed infertile women. Methods: In this randomized controlled trial research, 60 infertile women who had undergone in vitro fertilization (IVF) treatment with depression scores between 16-47 were divided into two groups. The intervention group with fluoxetine capsule was under treatment for two months before the embryo transfer, while the control group was given placebo. Depression score, serum levels of tumor necrosis factor alpha (TNF-α) as well as cortisol hormone levels were measured and recorded both before and after the intervention. The data were analyzed using SPSS version 21 software. Results: We analyzed the data related to 55 subjects who had undergone embryo transfer. 7 subjects in the intervention group and 3 in the control group got pregnant. We observed a significant decrease in the depression score (p < 0/001) and serum levels of cortisol (p = 0/001) in the intervention group. There was a significant increase in the serum levels of TNF-α in the intervention group (p < 0/001). There was a significant difference between the two groups in the number of pregnancies (p = 0.04). However, there was no statistical difference between them with regard to the number of harvested oocytes (p = 0.174). Discussion: Decrease in depression score and cortisol level, and an increase in the levels of TNF-α in the intervention group caused any changes in the number of oocytes in comparison with the control group. However, the number of pregnancies was larger in the intervention group.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/acp/article/view/168071
10.1590/0101-60830000000222
url https://www.revistas.usp.br/acp/article/view/168071
identifier_str_mv 10.1590/0101-60830000000222
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/acp/article/view/168071/160037
dc.rights.driver.fl_str_mv Copyright (c) 2020 Archives of Clinical Psychiatry
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Archives of Clinical Psychiatry
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria
dc.source.none.fl_str_mv Archives of Clinical Psychiatry; v. 47 n. 1 (2020); 7-12
Archives of Clinical Psychiatry; Vol. 47 No. 1 (2020); 7-12
Revista de Psiquiatria Clínica; Vol. 47 Núm. 1 (2020); 7-12
1806-938X
0101-6083
reponame:Archives of Clinical Psychiatry
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Archives of Clinical Psychiatry
collection Archives of Clinical Psychiatry
repository.name.fl_str_mv Archives of Clinical Psychiatry - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||archives@usp.br
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