Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Archives of Clinical Psychiatry |
Texto Completo: | https://www.revistas.usp.br/acp/article/view/148060 |
Resumo: | Background: Lithium is often used in bipolar disorder and occasionally in unipolar depression. Non-steroidal anti-inflammatory drugs (NSAIDs) and diuretics are frequently prescribed and their interaction with lithium is based mainly in few small studies. Objectives: Conduct a review, identify different interaction patterns and discuss treatment options. Methods: Three searches were made in PubMed in January 2016: 1) using the keywords “lithium” [and] “non-steroidal anti-inflammatory”; 2) using the keywords “lithium” [and] “diuretics” and the filter “title/abstract”; 3) using the terms “lithium” [and] “toxicity” and the filters “title” [and] “review”. From the 293 remaining articles, 10 were selected. Another search in Scielo.org was made, using the term “lítio” and the filter “Psiquiatria”. Two articles were selected from the initial 53. Six textbooks were added to expand the evidence, achieving a total of 18 references. Results: The majority of NSAIDs and diuretics rises lithium levels, specially thiazides. However, some show great variability or no interaction at all, and others even decrease lithium levels. Discussion: Lower-doses, shorter durations, lithium adjustments and levels' follow-ups are recommended, especially in elderly and multiple co-morbid patients. |
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Archives of Clinical Psychiatry |
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Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A reviewLithiumnon-steroidal anti-inflammatory drugsdiureticsdrug interactionssafety Background: Lithium is often used in bipolar disorder and occasionally in unipolar depression. Non-steroidal anti-inflammatory drugs (NSAIDs) and diuretics are frequently prescribed and their interaction with lithium is based mainly in few small studies. Objectives: Conduct a review, identify different interaction patterns and discuss treatment options. Methods: Three searches were made in PubMed in January 2016: 1) using the keywords “lithium” [and] “non-steroidal anti-inflammatory”; 2) using the keywords “lithium” [and] “diuretics” and the filter “title/abstract”; 3) using the terms “lithium” [and] “toxicity” and the filters “title” [and] “review”. From the 293 remaining articles, 10 were selected. Another search in Scielo.org was made, using the term “lítio” and the filter “Psiquiatria”. Two articles were selected from the initial 53. Six textbooks were added to expand the evidence, achieving a total of 18 references. Results: The majority of NSAIDs and diuretics rises lithium levels, specially thiazides. However, some show great variability or no interaction at all, and others even decrease lithium levels. Discussion: Lower-doses, shorter durations, lithium adjustments and levels' follow-ups are recommended, especially in elderly and multiple co-morbid patients.Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria2018-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/acp/article/view/14806010.1590/0101-60830000000153Archives of Clinical Psychiatry; v. 45 n. 2 (2018); 38-40Archives of Clinical Psychiatry; Vol. 45 No. 2 (2018); 38-40Revista de Psiquiatria Clínica; Vol. 45 Núm. 2 (2018); 38-401806-938X0101-6083reponame:Archives of Clinical Psychiatryinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/acp/article/view/148060/141635Copyright (c) 2018 Archives of Clinical Psychiatryinfo:eu-repo/semantics/openAccessNunes, Rui Pedro2018-07-12T13:43:42Zoai:revistas.usp.br:article/148060Revistahttp://www.hcnet.usp.br/ipq/revista/index.htmlPUBhttps://old.scielo.br/oai/scielo-oai.php||archives@usp.br1806-938X0101-6083opendoar:2018-07-12T13:43:42Archives of Clinical Psychiatry - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review |
title |
Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review |
spellingShingle |
Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review Nunes, Rui Pedro Lithium non-steroidal anti-inflammatory drugs diuretics drug interactions safety |
title_short |
Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review |
title_full |
Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review |
title_fullStr |
Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review |
title_full_unstemmed |
Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review |
title_sort |
Lithium interactions with non-steroidal anti-inflammatory drugs and diuretics – A review |
author |
Nunes, Rui Pedro |
author_facet |
Nunes, Rui Pedro |
author_role |
author |
dc.contributor.author.fl_str_mv |
Nunes, Rui Pedro |
dc.subject.por.fl_str_mv |
Lithium non-steroidal anti-inflammatory drugs diuretics drug interactions safety |
topic |
Lithium non-steroidal anti-inflammatory drugs diuretics drug interactions safety |
description |
Background: Lithium is often used in bipolar disorder and occasionally in unipolar depression. Non-steroidal anti-inflammatory drugs (NSAIDs) and diuretics are frequently prescribed and their interaction with lithium is based mainly in few small studies. Objectives: Conduct a review, identify different interaction patterns and discuss treatment options. Methods: Three searches were made in PubMed in January 2016: 1) using the keywords “lithium” [and] “non-steroidal anti-inflammatory”; 2) using the keywords “lithium” [and] “diuretics” and the filter “title/abstract”; 3) using the terms “lithium” [and] “toxicity” and the filters “title” [and] “review”. From the 293 remaining articles, 10 were selected. Another search in Scielo.org was made, using the term “lítio” and the filter “Psiquiatria”. Two articles were selected from the initial 53. Six textbooks were added to expand the evidence, achieving a total of 18 references. Results: The majority of NSAIDs and diuretics rises lithium levels, specially thiazides. However, some show great variability or no interaction at all, and others even decrease lithium levels. Discussion: Lower-doses, shorter durations, lithium adjustments and levels' follow-ups are recommended, especially in elderly and multiple co-morbid patients. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/acp/article/view/148060 10.1590/0101-60830000000153 |
url |
https://www.revistas.usp.br/acp/article/view/148060 |
identifier_str_mv |
10.1590/0101-60830000000153 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/acp/article/view/148060/141635 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Archives of Clinical Psychiatry info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Archives of Clinical Psychiatry |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria |
dc.source.none.fl_str_mv |
Archives of Clinical Psychiatry; v. 45 n. 2 (2018); 38-40 Archives of Clinical Psychiatry; Vol. 45 No. 2 (2018); 38-40 Revista de Psiquiatria Clínica; Vol. 45 Núm. 2 (2018); 38-40 1806-938X 0101-6083 reponame:Archives of Clinical Psychiatry instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Archives of Clinical Psychiatry |
collection |
Archives of Clinical Psychiatry |
repository.name.fl_str_mv |
Archives of Clinical Psychiatry - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||archives@usp.br |
_version_ |
1800237624181391360 |