PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Archives of Clinical Psychiatry |
Texto Completo: | https://www.revistas.usp.br/acp/article/view/180714 |
Resumo: | Background: Substance use and smoking exert devastating impact on sleep, especially hindering the ease of falling asleep, compromising the sleep maintenance, and distorting the sleep cycles. PERIOD genes are believed to play a role in individual differences in sleep timing by influencing circadian. Objective: The aim of this study was to ascertain whether Per3 VNTR variant affects suspectibility of individuals to substance use disorder (SUD) and smoking status in a Turkish population. Methods: A total of 549 subjects, including 212 SUD patients, 160 smoker, and 177 healthy controls, matched by ethnicity, age, and gender, were recruited in a case-control study. Genotyping of Per3 variant was performed using PCR method. Results: When the SUD, smoker groups and controls were compared in terms of 5R/5R, 5R/4R, 4R/4R genotypes, no significant difference was observed. Besides, allele frequencies of Per3 VNTR were similar among the groups. Discussion: Our data indicate that Per3 VNTR variant is not associated with the risk of SUD and smoking status in our population. |
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Archives of Clinical Psychiatry |
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PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish populationSubstance use disordersmoking statusPer3VNTRPCRBackground: Substance use and smoking exert devastating impact on sleep, especially hindering the ease of falling asleep, compromising the sleep maintenance, and distorting the sleep cycles. PERIOD genes are believed to play a role in individual differences in sleep timing by influencing circadian. Objective: The aim of this study was to ascertain whether Per3 VNTR variant affects suspectibility of individuals to substance use disorder (SUD) and smoking status in a Turkish population. Methods: A total of 549 subjects, including 212 SUD patients, 160 smoker, and 177 healthy controls, matched by ethnicity, age, and gender, were recruited in a case-control study. Genotyping of Per3 variant was performed using PCR method. Results: When the SUD, smoker groups and controls were compared in terms of 5R/5R, 5R/4R, 4R/4R genotypes, no significant difference was observed. Besides, allele frequencies of Per3 VNTR were similar among the groups. Discussion: Our data indicate that Per3 VNTR variant is not associated with the risk of SUD and smoking status in our population.Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria2019-06-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/acp/article/view/18071410.1590/0101-60830000000235Archives of Clinical Psychiatry; v. 47 n. 3 (2020); 71-74Archives of Clinical Psychiatry; Vol. 47 No. 3 (2020); 71-74Revista de Psiquiatria Clínica; Vol. 47 Núm. 3 (2020); 71-741806-938X0101-6083reponame:Archives of Clinical Psychiatryinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/acp/article/view/180714/167809Copyright (c) 2019 Archives of Clinical Psychiatryinfo:eu-repo/semantics/openAccessNursal, Ayse Feyda Aydı, Pinar Cetinay Uysal, Mehmet Atilla Pehliva, Mustafa Oyaci, Yasemin Pehliva, Sacide 2021-02-18T19:58:47Zoai:revistas.usp.br:article/180714Revistahttp://www.hcnet.usp.br/ipq/revista/index.htmlPUBhttps://old.scielo.br/oai/scielo-oai.php||archives@usp.br1806-938X0101-6083opendoar:2021-02-18T19:58:47Archives of Clinical Psychiatry - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population |
title |
PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population |
spellingShingle |
PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population Nursal, Ayse Feyda Substance use disorder smoking status Per3 VNTR PCR |
title_short |
PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population |
title_full |
PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population |
title_fullStr |
PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population |
title_full_unstemmed |
PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population |
title_sort |
PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population |
author |
Nursal, Ayse Feyda |
author_facet |
Nursal, Ayse Feyda Aydı, Pinar Cetinay Uysal, Mehmet Atilla Pehliva, Mustafa Oyaci, Yasemin Pehliva, Sacide |
author_role |
author |
author2 |
Aydı, Pinar Cetinay Uysal, Mehmet Atilla Pehliva, Mustafa Oyaci, Yasemin Pehliva, Sacide |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Nursal, Ayse Feyda Aydı, Pinar Cetinay Uysal, Mehmet Atilla Pehliva, Mustafa Oyaci, Yasemin Pehliva, Sacide |
dc.subject.por.fl_str_mv |
Substance use disorder smoking status Per3 VNTR PCR |
topic |
Substance use disorder smoking status Per3 VNTR PCR |
description |
Background: Substance use and smoking exert devastating impact on sleep, especially hindering the ease of falling asleep, compromising the sleep maintenance, and distorting the sleep cycles. PERIOD genes are believed to play a role in individual differences in sleep timing by influencing circadian. Objective: The aim of this study was to ascertain whether Per3 VNTR variant affects suspectibility of individuals to substance use disorder (SUD) and smoking status in a Turkish population. Methods: A total of 549 subjects, including 212 SUD patients, 160 smoker, and 177 healthy controls, matched by ethnicity, age, and gender, were recruited in a case-control study. Genotyping of Per3 variant was performed using PCR method. Results: When the SUD, smoker groups and controls were compared in terms of 5R/5R, 5R/4R, 4R/4R genotypes, no significant difference was observed. Besides, allele frequencies of Per3 VNTR were similar among the groups. Discussion: Our data indicate that Per3 VNTR variant is not associated with the risk of SUD and smoking status in our population. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-12 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/acp/article/view/180714 10.1590/0101-60830000000235 |
url |
https://www.revistas.usp.br/acp/article/view/180714 |
identifier_str_mv |
10.1590/0101-60830000000235 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/acp/article/view/180714/167809 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2019 Archives of Clinical Psychiatry info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2019 Archives of Clinical Psychiatry |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria |
publisher.none.fl_str_mv |
Universidade de São Paulo. Faculdade de Medicina. Instituto de Psiquiatria |
dc.source.none.fl_str_mv |
Archives of Clinical Psychiatry; v. 47 n. 3 (2020); 71-74 Archives of Clinical Psychiatry; Vol. 47 No. 3 (2020); 71-74 Revista de Psiquiatria Clínica; Vol. 47 Núm. 3 (2020); 71-74 1806-938X 0101-6083 reponame:Archives of Clinical Psychiatry instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Archives of Clinical Psychiatry |
collection |
Archives of Clinical Psychiatry |
repository.name.fl_str_mv |
Archives of Clinical Psychiatry - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||archives@usp.br |
_version_ |
1800237624332386304 |