Expressão das metaloproteinases da matriz 2 e 9 na saliva de pacientes com doença pulmonar obstrutiva crônica

• Autor(a) principal: Santos, Alecsandra Aparecida dos
• Data de Publicação: 2009
• Outros Autores: Malaguti, Carla, Corso, Simone Dal, Silva, Carlos Alberto da
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Fisioterapia e Pesquisa
• Texto Completo: https://www.revistas.usp.br/fpusp/article/view/12150
• topic: Doença pulmonar obstrutiva crônica; Metaloproteinase 2 da matriz; Metaloproteinase 9 da matriz; Saliva; Matrix metalloproteinase 2; Matrix metalloproteinase 9; Pulmonary disease; chronic obstructive; Saliva

The increased expression of matrix metalloproteinases (MMP) is considered a key factor in the development of chronic obstructive pulmonary disease (COPD). This study aimed at assessing expression levels of MMP-2 and MMP-9 in saliva from patients with COPD, comparing them to those of healthy subjects, thus assessing the feasibility of characterizing specific biomarkers for COPD. Patients with COPD (n=16) and healthy controls (n=9) were selected; both groups submitted to spirometry and to collection of saliva samples. Saliva levels of MMP-2 and MMP-9 were determined by Western blot. MMP-2 and MMP-9 levels were significantly higher in COPD patients than in control subjects. In COPD patients, a moderate, negative correlation was found between MMP-2 concentration and forced expiatory volume at the first second (r= -0.582; p=0.014). These findings open new perspectives to study specific biomarkers in saliva to predict and monitor airway obstruction in COPD patients.