Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets

Detalhes bibliográficos
Autor(a) principal: Ezeagu, Henry Ifeanyi
Data de Publicação: 2021
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Biblioteca Digital de Teses e Dissertações da USP
Texto Completo: https://www.teses.usp.br/teses/disponiveis/9/9139/tde-23022022-163911/
Resumo: The purpose of this work was to elaborate a diagnosis of the dissolution test in Africa in comparison with Brazil, evaluating the dissolution profile of low solubility drugs such as albendazole, ibuprofen, furosemide, glibenclamide, hydrochlorothiazide and carvedilol to ascertain their quality. The dissolution profiles were evaluated by utilizing the United States Pharmacopeia (USP). The glibenclamide medicine was evaluated according to the Food and Drug Administration (FDA), while a dissolution method was developed for the carvedilol medicine. A filter selection test for all the drugs showed that cannula is suitable for all, except for carvedilol, which is centrifuged. The various brands of Nigerian and Brazilian medicines tested showed some statistical differences. The suitable conditions that allowed the dissolution of carvedilol to be determined were the USP type II apparatus at 75 rpm containing 900 mL of acetate buffer, pH 4.5. The results of the dissolution test showed that out of the 17 different brands of Brazilian medicines and 17 different products from Nigeria, 94.12% and 58.82% passed respectively.
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spelling Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical marketsPerfil de dissolução das diferentes marcas de medicamentos de baixa solubilidade disponíveis no mercado farmacêutico Nigeriano e BrasileiroComprimidosDissolution profileDissolution testFármacos de baixa solubilidadeLow solubility drugsPerfil de dissoluçãoTabletsTeste de dissoluçãoThe purpose of this work was to elaborate a diagnosis of the dissolution test in Africa in comparison with Brazil, evaluating the dissolution profile of low solubility drugs such as albendazole, ibuprofen, furosemide, glibenclamide, hydrochlorothiazide and carvedilol to ascertain their quality. The dissolution profiles were evaluated by utilizing the United States Pharmacopeia (USP). The glibenclamide medicine was evaluated according to the Food and Drug Administration (FDA), while a dissolution method was developed for the carvedilol medicine. A filter selection test for all the drugs showed that cannula is suitable for all, except for carvedilol, which is centrifuged. The various brands of Nigerian and Brazilian medicines tested showed some statistical differences. The suitable conditions that allowed the dissolution of carvedilol to be determined were the USP type II apparatus at 75 rpm containing 900 mL of acetate buffer, pH 4.5. The results of the dissolution test showed that out of the 17 different brands of Brazilian medicines and 17 different products from Nigeria, 94.12% and 58.82% passed respectively.O objetivo deste trabalho foi elaborar um diagnóstico do teste de dissolução na África em comparação ao Brasil, avaliando o perfil de dissolução de medicamentos de baixa solubilidade como albendazol, ibuprofeno, furosemida, glibenclamida, hidroclorotiazida e carvedilol para verificar sua qualidade.Os perfis de dissolução foram avaliados utilizando a Farmacopeia dos Estados Unidos (USP). O medicamento glibenclamida foi avaliado de acordo com a Food and Drug Administration (FDA), enquanto um método de dissolução foi desenvolvido para o medicamento carvedilol.Um teste de seleção de filtro para todos os medicamentos mostrou que a cânula é adequada para todos, exceto para o carvedilol, que é centrifugado. As diversas marcas de medicamentos Nigerianos e Brasileiros testadas apresentaram algumas diferenças estatísticas. As condições adequadas que permitiram a determinação da dissolução do carvedilol foram o aparelho USP tipo II a 75 rpm contendo 900 mL de tampão acetato, pH 4,5. Os resultados do teste de dissolução mostraram que das 17 diferentes marcas de medicamentos brasileiros e 17 diferentes produtos da Nigéria, 94,12% e 58,82% foram aprovados, respectivamente.Biblioteca Digitais de Teses e Dissertações da USPFerraz, Humberto GomesEzeagu, Henry Ifeanyi2021-06-23info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttps://www.teses.usp.br/teses/disponiveis/9/9139/tde-23022022-163911/reponame:Biblioteca Digital de Teses e Dissertações da USPinstname:Universidade de São Paulo (USP)instacron:USPLiberar o conteúdo para acesso público.info:eu-repo/semantics/openAccesseng2022-02-24T15:15:02Zoai:teses.usp.br:tde-23022022-163911Biblioteca Digital de Teses e Dissertaçõeshttp://www.teses.usp.br/PUBhttp://www.teses.usp.br/cgi-bin/mtd2br.plvirginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.bropendoar:27212022-02-24T15:15:02Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets
Perfil de dissolução das diferentes marcas de medicamentos de baixa solubilidade disponíveis no mercado farmacêutico Nigeriano e Brasileiro
title Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets
spellingShingle Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets
Ezeagu, Henry Ifeanyi
Comprimidos
Dissolution profile
Dissolution test
Fármacos de baixa solubilidade
Low solubility drugs
Perfil de dissolução
Tablets
Teste de dissolução
title_short Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets
title_full Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets
title_fullStr Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets
title_full_unstemmed Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets
title_sort Dissolution profile of different brands of low solubility drugs available in the Nigerian and Brazilian pharmaceutical markets
author Ezeagu, Henry Ifeanyi
author_facet Ezeagu, Henry Ifeanyi
author_role author
dc.contributor.none.fl_str_mv Ferraz, Humberto Gomes
dc.contributor.author.fl_str_mv Ezeagu, Henry Ifeanyi
dc.subject.por.fl_str_mv Comprimidos
Dissolution profile
Dissolution test
Fármacos de baixa solubilidade
Low solubility drugs
Perfil de dissolução
Tablets
Teste de dissolução
topic Comprimidos
Dissolution profile
Dissolution test
Fármacos de baixa solubilidade
Low solubility drugs
Perfil de dissolução
Tablets
Teste de dissolução
description The purpose of this work was to elaborate a diagnosis of the dissolution test in Africa in comparison with Brazil, evaluating the dissolution profile of low solubility drugs such as albendazole, ibuprofen, furosemide, glibenclamide, hydrochlorothiazide and carvedilol to ascertain their quality. The dissolution profiles were evaluated by utilizing the United States Pharmacopeia (USP). The glibenclamide medicine was evaluated according to the Food and Drug Administration (FDA), while a dissolution method was developed for the carvedilol medicine. A filter selection test for all the drugs showed that cannula is suitable for all, except for carvedilol, which is centrifuged. The various brands of Nigerian and Brazilian medicines tested showed some statistical differences. The suitable conditions that allowed the dissolution of carvedilol to be determined were the USP type II apparatus at 75 rpm containing 900 mL of acetate buffer, pH 4.5. The results of the dissolution test showed that out of the 17 different brands of Brazilian medicines and 17 different products from Nigeria, 94.12% and 58.82% passed respectively.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-23
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.teses.usp.br/teses/disponiveis/9/9139/tde-23022022-163911/
url https://www.teses.usp.br/teses/disponiveis/9/9139/tde-23022022-163911/
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv
dc.rights.driver.fl_str_mv Liberar o conteúdo para acesso público.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Liberar o conteúdo para acesso público.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv
dc.publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
dc.source.none.fl_str_mv
reponame:Biblioteca Digital de Teses e Dissertações da USP
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Biblioteca Digital de Teses e Dissertações da USP
collection Biblioteca Digital de Teses e Dissertações da USP
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)
repository.mail.fl_str_mv virginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.br
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