Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci

Detalhes bibliográficos
Autor(a) principal: Amadeu, Rodrigo Rampazo
Data de Publicação: 2018
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Biblioteca Digital de Teses e Dissertações da USP
Texto Completo: http://www.teses.usp.br/teses/disponiveis/11/11137/tde-25072018-181323/
Resumo: Crops, such as sugarcane, potato, and several forages and berries, are autopolyploids. In plant breeding studies, a key subject is the pairwise relatedness between cultivars. This information can be incorporated in GWAS (genome-wide association) and GS (genomic selection) studies allowing powerful genetic analysis. Despite the autopolyploid importance in agriculture, they lack genetic studies considering ploidy level, and, therefore, polyssomic inheritance. Our objective in this work is: i) to investigate, through simulations, different molecular pairwise relatedness estimators; ii) to recommend which one is the best to be used in different scenarios regarding characteristic as number of loci, number of alleles, ploidy level, double-reduction, and inbreeding level. Our recommendations may guide autopolyploid breeding programs will be able to choose the best strategies and estimators based their reality.
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spelling Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many lociParentesco molecular em autopoliploides: um estudo de simulação considerando lingação e muitos lociAutotetraploidesAutotetraploidsMarcador molecularMolecular markerMolecular relationshipParentesco molecularPoliploidesPolyploidSNPSNPCrops, such as sugarcane, potato, and several forages and berries, are autopolyploids. In plant breeding studies, a key subject is the pairwise relatedness between cultivars. This information can be incorporated in GWAS (genome-wide association) and GS (genomic selection) studies allowing powerful genetic analysis. Despite the autopolyploid importance in agriculture, they lack genetic studies considering ploidy level, and, therefore, polyssomic inheritance. Our objective in this work is: i) to investigate, through simulations, different molecular pairwise relatedness estimators; ii) to recommend which one is the best to be used in different scenarios regarding characteristic as number of loci, number of alleles, ploidy level, double-reduction, and inbreeding level. Our recommendations may guide autopolyploid breeding programs will be able to choose the best strategies and estimators based their reality.Culturas agrícolas como cana-de-açúcar, batata, batata doce, diferentes forrageiras e frutas são autopoliploides. Em melhoramento de plantas, o conhecimento do parentesco entre cultivares é crítico. Essa informação pode ser incorporada em estudos de GWAS (genome-wide association studies) e GS (genomic selection) permitindo uma análise genética e predição de QTLs e valores genéticos de maior poder estatístico. No entanto, faltam estudos genéticos que considerem parentesco em um cenário autopoliploide. Nossos objetivos neste trabalho são: i) investigar, através de simulações, diferentes estimadores de parentesco entre indivíduos; ii) recomendar o melhor estimador basedo em cenários específicos considerando diferentes número de loci, número de alelos, ploidia, nível de dupla-redução e endogamia. Nossas recomendações poderão orientar estratégias de programas de melhoramento genético de espécies autopoliploides para escolha de estimadores baseados em seu cenário específico.Biblioteca Digitais de Teses e Dissertações da USPGarcia, Antonio Augusto FrancoAmadeu, Rodrigo Rampazo2018-03-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://www.teses.usp.br/teses/disponiveis/11/11137/tde-25072018-181323/reponame:Biblioteca Digital de Teses e Dissertações da USPinstname:Universidade de São Paulo (USP)instacron:USPLiberar o conteúdo para acesso público.info:eu-repo/semantics/openAccesseng2022-03-14T13:00:02Zoai:teses.usp.br:tde-25072018-181323Biblioteca Digital de Teses e Dissertaçõeshttp://www.teses.usp.br/PUBhttp://www.teses.usp.br/cgi-bin/mtd2br.plvirginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.bropendoar:27212022-03-14T13:00:02Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci
Parentesco molecular em autopoliploides: um estudo de simulação considerando lingação e muitos loci
title Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci
spellingShingle Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci
Amadeu, Rodrigo Rampazo
Autotetraploides
Autotetraploids
Marcador molecular
Molecular marker
Molecular relationship
Parentesco molecular
Poliploides
Polyploid
SNP
SNP
title_short Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci
title_full Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci
title_fullStr Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci
title_full_unstemmed Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci
title_sort Molecular pairwise relatedness in autopolyploids: a simulation study considering linkage and many loci
author Amadeu, Rodrigo Rampazo
author_facet Amadeu, Rodrigo Rampazo
author_role author
dc.contributor.none.fl_str_mv Garcia, Antonio Augusto Franco
dc.contributor.author.fl_str_mv Amadeu, Rodrigo Rampazo
dc.subject.por.fl_str_mv Autotetraploides
Autotetraploids
Marcador molecular
Molecular marker
Molecular relationship
Parentesco molecular
Poliploides
Polyploid
SNP
SNP
topic Autotetraploides
Autotetraploids
Marcador molecular
Molecular marker
Molecular relationship
Parentesco molecular
Poliploides
Polyploid
SNP
SNP
description Crops, such as sugarcane, potato, and several forages and berries, are autopolyploids. In plant breeding studies, a key subject is the pairwise relatedness between cultivars. This information can be incorporated in GWAS (genome-wide association) and GS (genomic selection) studies allowing powerful genetic analysis. Despite the autopolyploid importance in agriculture, they lack genetic studies considering ploidy level, and, therefore, polyssomic inheritance. Our objective in this work is: i) to investigate, through simulations, different molecular pairwise relatedness estimators; ii) to recommend which one is the best to be used in different scenarios regarding characteristic as number of loci, number of alleles, ploidy level, double-reduction, and inbreeding level. Our recommendations may guide autopolyploid breeding programs will be able to choose the best strategies and estimators based their reality.
publishDate 2018
dc.date.none.fl_str_mv 2018-03-14
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.teses.usp.br/teses/disponiveis/11/11137/tde-25072018-181323/
url http://www.teses.usp.br/teses/disponiveis/11/11137/tde-25072018-181323/
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv
dc.rights.driver.fl_str_mv Liberar o conteúdo para acesso público.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Liberar o conteúdo para acesso público.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv
dc.publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
dc.source.none.fl_str_mv
reponame:Biblioteca Digital de Teses e Dissertações da USP
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Biblioteca Digital de Teses e Dissertações da USP
collection Biblioteca Digital de Teses e Dissertações da USP
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)
repository.mail.fl_str_mv virginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.br
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