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Detalhes bibliográficos
Autor(a) principal: Valente, Angélica Marques Martins
Data de Publicação: 2019
Tipo de documento: Tese
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da USP
Texto Completo: http://www.teses.usp.br/teses/disponiveis/6/6141/tde-26062019-094805/
Resumo: Não disponível
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spelling Não disponívelAssociations of birth weight with dual-energy x-ray absorptiometry-determined body composition, bone densitometry and cardiometabolic risk profile in young women from the Nutritionists\' Health StudyBirth WeightBody CompositionBone MassCardiometabolic RiskDOHaDDXAMuscle MassNão disponívelOsteosarcopeniaVisceral Adipose TissueNão disponívelBackground: Visceral adiposity is a risk factor for cardiometabolic diseases and dual-energy x-ray absorptiometry (DXA) represents precise method for measuring visceral adipose tissue (VAT), muscle and bone compartments. The musculoskeletal system deteriorates with aging and may result in osteosarcopenia. Since known risk factors do not fully explain the occurrence of osteosarcopenia, the search for new causal factors, as birth weight (BW) is promising. Objectives: To evaluate whether BW was associated with DXA-determined body composition, bone densitometry and cardiometabolic risk markers in young women from the NutriHS. Paper 1 objective: to propose reference values for DXA-determined VAT, and to test their ability to identify the cardiometabolic risk profile. Paper 2: to examine whether BW was associated with muscle and bone DXA-determined parameters. Paper 3: to investigate whether parameters of muscle and bone compartments were associated and possible predictive factors of these compartments throughout life. Methods: NutriHS is a cohort study conducted in undergraduates and Nutrition graduates and here cross-sectional analyses were performed in 201 healthy women (20-45 years). They answered questionnaires and had anthropometry, muscle strength and performance, DXA-determined body composition and bone densitometry obtained. A random sample of 148 participants had also laboratory tests collected. Multiple regression models, using the directed acyclic graphs-recommended adjustments, were employed. Results: Median age was 23 years and mean BMI was 22.9±2.9 kg/m2. Paper 1: Mean VAT mass and volume were 221.0±306.1 g and 231.8±323.8 cm3, respectively. The third tertiles of VAT were significantly associated with increased frequencies of abnormal anthropometry, HOMA-IR and TyG indexes. Paper 2: Mean BW was 3,199±424 g; BW in quartiles was significantly associated with several muscle and bone parameters. Paper 3: Direct, strong and independent associations between bone and muscle variables were detected. Discussion: Cutoffs for DXA-derived VAT mass (221.0 g) and volume (231.8 cm3) are being suggested for Brazilian young women; these seem able to disclose a mild visceral fat accumulation, prior the deterioration of glucose and lipid metabolism. The role of BW as an early marker for muscle and bone states in young adulthood was shown. In addition, a musculoskeletal profile for a healthy stratus of the Brazilian women was firstly described. Our findings indicated a muscle-bone crosstalk even in young adults and suggested predictive factors (such as BW, physical activity, smoking) of muscle and bone compartments.Biblioteca Digitais de Teses e Dissertações da USPPititto, Bianca de AlmeidaVivolo, Sandra Roberta Gouvea FerreiraValente, Angélica Marques Martins2019-03-29info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisapplication/pdfhttp://www.teses.usp.br/teses/disponiveis/6/6141/tde-26062019-094805/reponame:Biblioteca Digital de Teses e Dissertações da USPinstname:Universidade de São Paulo (USP)instacron:USPLiberar o conteúdo para acesso público.info:eu-repo/semantics/openAccesspor2019-07-04T17:52:53Zoai:teses.usp.br:tde-26062019-094805Biblioteca Digital de Teses e Dissertaçõeshttp://www.teses.usp.br/PUBhttp://www.teses.usp.br/cgi-bin/mtd2br.plvirginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.bropendoar:27212019-07-04T17:52:53Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Não disponível
Associations of birth weight with dual-energy x-ray absorptiometry-determined body composition, bone densitometry and cardiometabolic risk profile in young women from the Nutritionists\' Health Study
title Não disponível
spellingShingle Não disponível
Valente, Angélica Marques Martins
Birth Weight
Body Composition
Bone Mass
Cardiometabolic Risk
DOHaD
DXA
Muscle Mass
Não disponível
Osteosarcopenia
Visceral Adipose Tissue
title_short Não disponível
title_full Não disponível
title_fullStr Não disponível
title_full_unstemmed Não disponível
title_sort Não disponível
author Valente, Angélica Marques Martins
author_facet Valente, Angélica Marques Martins
author_role author
dc.contributor.none.fl_str_mv Pititto, Bianca de Almeida
Vivolo, Sandra Roberta Gouvea Ferreira
dc.contributor.author.fl_str_mv Valente, Angélica Marques Martins
dc.subject.por.fl_str_mv Birth Weight
Body Composition
Bone Mass
Cardiometabolic Risk
DOHaD
DXA
Muscle Mass
Não disponível
Osteosarcopenia
Visceral Adipose Tissue
topic Birth Weight
Body Composition
Bone Mass
Cardiometabolic Risk
DOHaD
DXA
Muscle Mass
Não disponível
Osteosarcopenia
Visceral Adipose Tissue
description Não disponível
publishDate 2019
dc.date.none.fl_str_mv 2019-03-29
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.teses.usp.br/teses/disponiveis/6/6141/tde-26062019-094805/
url http://www.teses.usp.br/teses/disponiveis/6/6141/tde-26062019-094805/
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv
dc.rights.driver.fl_str_mv Liberar o conteúdo para acesso público.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Liberar o conteúdo para acesso público.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv
dc.publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
publisher.none.fl_str_mv Biblioteca Digitais de Teses e Dissertações da USP
dc.source.none.fl_str_mv
reponame:Biblioteca Digital de Teses e Dissertações da USP
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Biblioteca Digital de Teses e Dissertações da USP
collection Biblioteca Digital de Teses e Dissertações da USP
repository.name.fl_str_mv Biblioteca Digital de Teses e Dissertações da USP - Universidade de São Paulo (USP)
repository.mail.fl_str_mv virginia@if.usp.br|| atendimento@aguia.usp.br||virginia@if.usp.br
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