Comparative histology of the human and teleost fish thymus / Histologia Comparativa de timo de humanos e peixes teleósteos

• Autor(a) principal: Klosterhoff, Marta da Costa
• Data de Publicação: 2020
• Outros Autores: de Medeiros, Ane Felice Frâncio, Guerreiro, Amanda, Pedrosa, Virgínia Fonseca, Romano, Luis Alberto
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Veras
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/16630
• topic: Histology; thymus; lymphocytes

Thymus is considered a key component of the vertebrates’ immune system. It is an organ that is only found in these animals whose development may be accompanied through the evolutionary scale, being considered as a facilitator and regulator in the interaction of lymphoid cells and lymphoid organs. In this study not only a morphological but also functional homology were demonstrated, in that it affects the immune system, of the humans and teleost fish thymus. The material of study was composed of the thymus tissue samples of humans who were donated by the Department of Pathology of Hospital Parmenio Piñero, Buenos Aires Argentina belonging to two patients with ages between 6 and 8 years, as well as specimens of fish from different origins. The thymic tissue samples were submitted to histological analysis, immunohistochemistry and transmission electron microscopy. Through the data shown here it is possible to consider that, both in fish as in humans, there are two tracks in the modulation of the immune response, an afferent pathway that begins with the presentation of the antigen and an efferent pathway through which  the result of the lymphocytes, antibodies stimulation  or other effector mechanisms are canalized. In these two phases both in humans and in fish, a mixed population of lymphocytes, the differentiation of lymphocytes in the thymus and the T4 lymphocytes production, play a fundamental role in the success of the immune response. Keywords: