Biological potential of diphenyl diselenide / Potencial biológico do disseleneto de difenila

• Autor(a) principal: Macena, Julio César
• Data de Publicação: 2021
• Outros Autores: Renzi, Daniele Fernanda, Grigoletto, Diana Fortkamp, Antunes Junior, Osmar dos Reis
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Veras
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/33463
• topic: Pharmacology; Selenium; Toxicity.

Diphenyl diselenide (DD) is an organic compound derived from selenium, has a low soluble lipophilic characteristic and is not indicated for oral administration. Known for its pharmacological effects, such as antiviral, cytotoxic, antifungal and antiviral, DD also shows some toxicity. In this review, the biological action of DD against different animal models was evaluated. Through this, it has been found that this compound has neuroprotective activity. DD increases the neurotransmission of endogenous opioids, being a potential candidate for the treatment of depression. The administration of DD dose in rats caused increased levels of selenium in the brain, reducing anxiety-like behaviors. The hypoglycemic effect can be evidenced by the reduction of blood glucose levels and glycated proteins in mice treated with DD. The antifungal action can be verified through the interaction of the DD and the sulfhydryl groups present in the proteins of fungal cells. The DD proved to be an option for the treatment of mercury poisoning and pesticides. Although there are several studies demonstrating the benefits of DD use, there are also reports of its toxicity due to its ability to cross the blood-brain barrier. In addition, acute and chronic exposure to DD can cause Se deposition in the liver, kidney, and brain. The objective of this review was to investigate the general properties of DD and to summarize some of its biological activities, demonstrating its potential for clinical use, based on in vitro and in vivo studies found in the literature.