Does Suppression Levels of Testosterone Have an Impact in The Craniofacial Growth? A Systematic Review in Animal Studies/ A supressão de testosterona impacta o crescimento craniofacial? Uma revisão sistemática de estudos com animais

• Autor(a) principal: Reis, Caio Luiz Bitencourt
• Data de Publicação: 2021
• Outros Autores: Guerra, Kelem Cambraia Caproni, Ramirez, Iago, Madalena, Isabela Ribeiro, Almeida, Ana Cláudia Pedreira de, Oliveira, Daniela Silva Barroso de
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Veras
• DOI: 10.34117/bjdv7n7-644
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/33685
• topic: Testosterone suppression; craniofacial growth; orchiectomy; mandible; maxilla

Sexual hormonal disturbances in humans alter the growth bone. Suppression testosterone is performed in animals for evaluated their effects on craniofacial complex. The aim of this study is to investigate, through of a systematic review from animal studies, the effects of testosterone suppression on the craniofacial complex development. Seven databases, including Open Grey literature, were searched since inception to March 01, 2021, following strategy MEDLINE for terms conducted the search. The study design PICOS was used to establish the eligibility criteria: P - Animals; I - Suppression of testosterone production; C - Animals with normal levels of testosterone; O - Effect in craniofacial growth/development; S - In vivo studies. Relevant data were collected and inserted in characteristics of studies table. Risk of bias was assessed using SYRCLE’s risk of bias tool. Ten studies were included in the systematic review. Two were classified with low risk of bias and eight with unclear. The mandible in experiment group was significantly smaller than control group. The trabecular bone mineral density of the mandible was decrease after testosterone suppression. There was an increase in the number of osteoclasts in the experimental groups. All cephalometric measurements of the maxilla, except in one study, were reduced in orchiectomized rats. The expression of androgen receptor was significantly reduced in head condyle of the experimental group. Testosterone suppression decreases the growth of craniofacial complex bones through imbalance of the bone turnover due to the increase in the number of osteoclasts.