A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection

Detalhes bibliográficos
Autor(a) principal: Guimarães, Luiz Henrique Santos
Data de Publicação: 2015
Outros Autores: Saldanha, Maíra, Menezes, Taís, Moreno, Lis, Torres, Alex José Leite, Costa, Rúbia Suely Santana, Passos, Sara Timoteo, Badaró, Roberto José da Silva, Arruda, Sérgio Marcos, Carvalho, Lucas Pedreira de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20150
Resumo: National Institute of Health (AI088650) and the Brazilian Council for research (CNPq).
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spelling Guimarães, Luiz Henrique SantosSaldanha, MaíraMenezes, TaísMoreno, LisTorres, Alex José LeiteCosta, Rúbia Suely SantanaPassos, Sara TimoteoBadaró, Roberto José da SilvaArruda, Sérgio MarcosCarvalho, Lucas Pedreira de2017-07-19T17:56:32Z2017-07-19T17:56:32Z2015GUIMARÃES, L. H. S. et al. A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection. American Journal of Tropical Medicine and Hygiene, v. 93, n. 6, p. 1219–1223. 2015.0002-9637https://www.arca.fiocruz.br/handle/icict/2015010.4269/ajtmh.14-0475National Institute of Health (AI088650) and the Brazilian Council for research (CNPq).Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Laboratório de Doenças Tropicais. Salvador, BA, BrasilUniversidade Federal da Bahia. Laboratório de Pesquisa em Infectologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilUniversidade Federal da Bahia. Laboratório de Doenças Tropicais. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, BrasilSkin ulcer development in cutaneous leishmaniasis due to Leishmania braziliensis infection is associated with a mononuclear cell infiltrate and high levels of tumor necrosis factor (TNF). Herein, we show that despite the absence of Leishmania-driven TNF, a cutaneous leishmaniasis patient with acquired immunodeficiency syndrome developed a skin ulcer. The presence of mononuclear phagocytes and high levels of TNF, chemokine (C-C motif) ligand 2 (CCL2), and metalloproteinase-9 in tissue are identified as potential contributors to immunopathology observed in L. braziliensis-infected patients.engAmerican Society of Tropical Medicine and HygieneLeishmania braziliensisLeishmaniose CutâneaInfecções por HIVFator de Necrose Tumoral alfaÚlcera da peleHumanosInfecçãoFagocitoseLeishmania braziliensisLeishmaniasis, CutaneousHIV InfectionsTumor Necrosis Factor-alphaSkin UlcerHumansCoinfectionPhagocytosisA Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
title A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
spellingShingle A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
Guimarães, Luiz Henrique Santos
Leishmania braziliensis
Leishmaniose Cutânea
Infecções por HIV
Fator de Necrose Tumoral alfa
Úlcera da pele
Humanos
Infecção
Fagocitose
Leishmania braziliensis
Leishmaniasis, Cutaneous
HIV Infections
Tumor Necrosis Factor-alpha
Skin Ulcer
Humans
Coinfection
Phagocytosis
title_short A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
title_full A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
title_fullStr A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
title_full_unstemmed A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
title_sort A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
author Guimarães, Luiz Henrique Santos
author_facet Guimarães, Luiz Henrique Santos
Saldanha, Maíra
Menezes, Taís
Moreno, Lis
Torres, Alex José Leite
Costa, Rúbia Suely Santana
Passos, Sara Timoteo
Badaró, Roberto José da Silva
Arruda, Sérgio Marcos
Carvalho, Lucas Pedreira de
author_role author
author2 Saldanha, Maíra
Menezes, Taís
Moreno, Lis
Torres, Alex José Leite
Costa, Rúbia Suely Santana
Passos, Sara Timoteo
Badaró, Roberto José da Silva
Arruda, Sérgio Marcos
Carvalho, Lucas Pedreira de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guimarães, Luiz Henrique Santos
Saldanha, Maíra
Menezes, Taís
Moreno, Lis
Torres, Alex José Leite
Costa, Rúbia Suely Santana
Passos, Sara Timoteo
Badaró, Roberto José da Silva
Arruda, Sérgio Marcos
Carvalho, Lucas Pedreira de
dc.subject.other.pt_BR.fl_str_mv Leishmania braziliensis
Leishmaniose Cutânea
Infecções por HIV
Fator de Necrose Tumoral alfa
Úlcera da pele
Humanos
Infecção
Fagocitose
topic Leishmania braziliensis
Leishmaniose Cutânea
Infecções por HIV
Fator de Necrose Tumoral alfa
Úlcera da pele
Humanos
Infecção
Fagocitose
Leishmania braziliensis
Leishmaniasis, Cutaneous
HIV Infections
Tumor Necrosis Factor-alpha
Skin Ulcer
Humans
Coinfection
Phagocytosis
dc.subject.en.pt_BR.fl_str_mv Leishmania braziliensis
Leishmaniasis, Cutaneous
HIV Infections
Tumor Necrosis Factor-alpha
Skin Ulcer
Humans
Coinfection
Phagocytosis
description National Institute of Health (AI088650) and the Brazilian Council for research (CNPq).
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2017-07-19T17:56:32Z
dc.date.available.fl_str_mv 2017-07-19T17:56:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUIMARÃES, L. H. S. et al. A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection. American Journal of Tropical Medicine and Hygiene, v. 93, n. 6, p. 1219–1223. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20150
dc.identifier.issn.pt_BR.fl_str_mv 0002-9637
dc.identifier.eissn.none.fl_str_mv 10.4269/ajtmh.14-0475
identifier_str_mv GUIMARÃES, L. H. S. et al. A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection. American Journal of Tropical Medicine and Hygiene, v. 93, n. 6, p. 1219–1223. 2015.
0002-9637
10.4269/ajtmh.14-0475
url https://www.arca.fiocruz.br/handle/icict/20150
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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