Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian journal of oral sciences (Online) |
Texto Completo: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642323 |
Resumo: | Aim: Several medications affect bone metabolism and the rate of tooth movement. The objective of the present study was to test the hypothesis that treatment with immunosuppressant tacrolimus (FK506) can interfere with bone turnover, decreasing the rate of tooth movement. Methods: Sixty male Wistar rats were divided into four groups of 15 animals each: Group 1: rats subjected to orthodontic movement plus treatment with saline solution vehicle; Group 2: rats subjected to orthodontic movement plus treatment with FK506; Group 3: rats treated with FK506 only; and Group 4: rats treated with saline solution vehicle only. The FK506 dose was 2 mg/kg/day. The treatment was initiated 14 days before the appliance installation and then kept for up to 14 days. In addition to the administration of the immunosuppressive drug, 10 mg/kg of oxytetracycline were injected at intervals of three days in order to show osteoblastic activity and bone growth at a histological level. Results: Histomorphometrical measurements showed greater tooth movement in Group 1 than in Group 2 at all periods (days 3, 7 and 14), though significant difference (p < 0.05) was observed only on days 7 and 14. Conclusions: FK506 significantly influenced the rate of tooth movement in rats subjected to the application of this medication. |
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UNICAMP-8 |
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Brazilian journal of oral sciences (Online) |
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Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506Tooth/immunologyTooth movementBone and bonesOdontologyAim: Several medications affect bone metabolism and the rate of tooth movement. The objective of the present study was to test the hypothesis that treatment with immunosuppressant tacrolimus (FK506) can interfere with bone turnover, decreasing the rate of tooth movement. Methods: Sixty male Wistar rats were divided into four groups of 15 animals each: Group 1: rats subjected to orthodontic movement plus treatment with saline solution vehicle; Group 2: rats subjected to orthodontic movement plus treatment with FK506; Group 3: rats treated with FK506 only; and Group 4: rats treated with saline solution vehicle only. The FK506 dose was 2 mg/kg/day. The treatment was initiated 14 days before the appliance installation and then kept for up to 14 days. In addition to the administration of the immunosuppressive drug, 10 mg/kg of oxytetracycline were injected at intervals of three days in order to show osteoblastic activity and bone growth at a histological level. Results: Histomorphometrical measurements showed greater tooth movement in Group 1 than in Group 2 at all periods (days 3, 7 and 14), though significant difference (p < 0.05) was observed only on days 7 and 14. Conclusions: FK506 significantly influenced the rate of tooth movement in rats subjected to the application of this medication.Universidade Estadual de Campinas2015-12-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/864232310.20396/bjos.v8i1.8642323Brazilian Journal of Oral Sciences; v. 8 n. 1 (2009): Apr./Jun.; 19-24Brazilian Journal of Oral Sciences; Vol. 8 No. 1 (2009): Apr./Jun.; 19-241677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPenghttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642323/9796Santos, Rogério Lacerda dosSouza, Marcos Farina deGonçalves, Renato TorresMartins, Marco AurélioSouza, Margareth Maria Gomes deinfo:eu-repo/semantics/openAccess2016-02-25T09:24:35Zoai:ojs.periodicos.sbu.unicamp.br:article/8642323Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2016-02-25T09:24:35Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506 |
title |
Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506 |
spellingShingle |
Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506 Santos, Rogério Lacerda dos Tooth/immunology Tooth movement Bone and bones Odontology |
title_short |
Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506 |
title_full |
Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506 |
title_fullStr |
Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506 |
title_full_unstemmed |
Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506 |
title_sort |
Histomorphometric study of alveolar bone after therapy with immunosuppressant FK506 |
author |
Santos, Rogério Lacerda dos |
author_facet |
Santos, Rogério Lacerda dos Souza, Marcos Farina de Gonçalves, Renato Torres Martins, Marco Aurélio Souza, Margareth Maria Gomes de |
author_role |
author |
author2 |
Souza, Marcos Farina de Gonçalves, Renato Torres Martins, Marco Aurélio Souza, Margareth Maria Gomes de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, Rogério Lacerda dos Souza, Marcos Farina de Gonçalves, Renato Torres Martins, Marco Aurélio Souza, Margareth Maria Gomes de |
dc.subject.por.fl_str_mv |
Tooth/immunology Tooth movement Bone and bones Odontology |
topic |
Tooth/immunology Tooth movement Bone and bones Odontology |
description |
Aim: Several medications affect bone metabolism and the rate of tooth movement. The objective of the present study was to test the hypothesis that treatment with immunosuppressant tacrolimus (FK506) can interfere with bone turnover, decreasing the rate of tooth movement. Methods: Sixty male Wistar rats were divided into four groups of 15 animals each: Group 1: rats subjected to orthodontic movement plus treatment with saline solution vehicle; Group 2: rats subjected to orthodontic movement plus treatment with FK506; Group 3: rats treated with FK506 only; and Group 4: rats treated with saline solution vehicle only. The FK506 dose was 2 mg/kg/day. The treatment was initiated 14 days before the appliance installation and then kept for up to 14 days. In addition to the administration of the immunosuppressive drug, 10 mg/kg of oxytetracycline were injected at intervals of three days in order to show osteoblastic activity and bone growth at a histological level. Results: Histomorphometrical measurements showed greater tooth movement in Group 1 than in Group 2 at all periods (days 3, 7 and 14), though significant difference (p < 0.05) was observed only on days 7 and 14. Conclusions: FK506 significantly influenced the rate of tooth movement in rats subjected to the application of this medication. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642323 10.20396/bjos.v8i1.8642323 |
url |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642323 |
identifier_str_mv |
10.20396/bjos.v8i1.8642323 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642323/9796 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Oral Sciences; v. 8 n. 1 (2009): Apr./Jun.; 19-24 Brazilian Journal of Oral Sciences; Vol. 8 No. 1 (2009): Apr./Jun.; 19-24 1677-3225 reponame:Brazilian journal of oral sciences (Online) instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Brazilian journal of oral sciences (Online) |
collection |
Brazilian journal of oral sciences (Online) |
repository.name.fl_str_mv |
Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
brjorals@fop.unicamp.br||brjorals@fop.unicamp.br |
_version_ |
1788167622399885312 |