Antimutagenic and anticarcinogenic effects of wheat bran in vivo

Detalhes bibliográficos
Autor(a) principal: Pesarini, J. R.
Data de Publicação: 2013
Outros Autores: Zaninetti, P. T., Mauro, M. O. [UNESP], Carreira, C. M., Dichi, J. B., Ribeiro, L. R. [UNESP], Mantovani, M. S., Oliveira, R. J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.4238/2013.May.14.5
http://hdl.handle.net/11449/75453
Resumo: Previous studies in rodents treated with the pro-carcinogen 1,2-dimethylhydrazine suggested that the consumption of wheat bran protected against DNA damage in the colon and rectum. Based on this information, we evaluated wheat bran as a functional food in the prevention and treatment of colon cancer. We used the aberrant crypt focus assay to evaluate the anticarcinogenic potential of wheat bran (Triticum aestivum variety CD-104), the comet assay to evaluate its antigenotoxicity potential, and the micronucleus assay to evaluate its antimutagenic potential. The wheat bran gave good antimutagenic and anticarcinogenic responses; the DNA damage decreased from 90.30 to 26.37% and from 63.35 to 28.73%, respectively. However, the wheat bran did not significantly reduce genotoxicity. Further tests will be necessary, including tests in human beings, before this functional food can be recommended as an adjunct in the prevention and treatment of colon cancer. © FUNPEC-RP.
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spelling Antimutagenic and anticarcinogenic effects of wheat bran in vivoChemopreventionFunctional foodTriticum aestivumWheat branDNAanimal experimentantineoplastic activityapoptosiscancer riskcell cyclecell proliferationcolon cancercomet assaycontrolled studyDNA damagegenotoxicityin vivo studymalemicronucleus testmousemutagenicitynonhumanwheat branPrevious studies in rodents treated with the pro-carcinogen 1,2-dimethylhydrazine suggested that the consumption of wheat bran protected against DNA damage in the colon and rectum. Based on this information, we evaluated wheat bran as a functional food in the prevention and treatment of colon cancer. We used the aberrant crypt focus assay to evaluate the anticarcinogenic potential of wheat bran (Triticum aestivum variety CD-104), the comet assay to evaluate its antigenotoxicity potential, and the micronucleus assay to evaluate its antimutagenic potential. The wheat bran gave good antimutagenic and anticarcinogenic responses; the DNA damage decreased from 90.30 to 26.37% and from 63.35 to 28.73%, respectively. However, the wheat bran did not significantly reduce genotoxicity. Further tests will be necessary, including tests in human beings, before this functional food can be recommended as an adjunct in the prevention and treatment of colon cancer. © FUNPEC-RP.Centro de Estudo em Nutrição e Genética Toxicológica Centro Universitário Filadélfia, Londrina, PRInstituto de Biociências de Rio Claro Universidade Estadual Paulista, Rio Claro, SPCentro de Estudos em Células Tronco Terapia Celular e Genética Toxicológica Núcleo de Hospital Universitário, Universidade Federal de Mato Grosso do Sul, Campo Grande, MSCentro de Ciências da Saúde Departamento de Ciências Farmacêuticas Universidade Estadual de Londrina, Londrina, PRCentro de Ciências Biológicas Departamento de Biologia Universidade Estadual de Londrina, Londrina, PRUniversidade Federal de Mato Grosso do Sul, Campo Grande, MSCentro de Ciências Biológicas e da Saúde Universidade Federal de Mato Grosso do Sul, Campo Grande, MSInstituto de Biociências de Rio Claro Universidade Estadual Paulista, Rio Claro, SPCentro Universitário FiladélfiaUniversidade Estadual Paulista (Unesp)Universidade Federal de Mato Grosso do Sul (UFMS)Universidade Estadual de Londrina (UEL)Pesarini, J. R.Zaninetti, P. T.Mauro, M. O. [UNESP]Carreira, C. M.Dichi, J. B.Ribeiro, L. R. [UNESP]Mantovani, M. S.Oliveira, R. J.2014-05-27T11:29:33Z2014-05-27T11:29:33Z2013-05-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1646-1659application/pdfhttp://dx.doi.org/10.4238/2013.May.14.5Genetics and Molecular Research, v. 12, n. 2, p. 1646-1659, 2013.1676-5680http://hdl.handle.net/11449/7545310.4238/2013.May.14.5WOS:0003200301000782-s2.0-848781040132-s2.0-84878104013.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and Molecular Research0,439info:eu-repo/semantics/openAccess2024-01-13T06:31:29Zoai:repositorio.unesp.br:11449/75453Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-13T06:31:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antimutagenic and anticarcinogenic effects of wheat bran in vivo
title Antimutagenic and anticarcinogenic effects of wheat bran in vivo
spellingShingle Antimutagenic and anticarcinogenic effects of wheat bran in vivo
Pesarini, J. R.
Chemoprevention
Functional food
Triticum aestivum
Wheat bran
DNA
animal experiment
antineoplastic activity
apoptosis
cancer risk
cell cycle
cell proliferation
colon cancer
comet assay
controlled study
DNA damage
genotoxicity
in vivo study
male
micronucleus test
mouse
mutagenicity
nonhuman
wheat bran
title_short Antimutagenic and anticarcinogenic effects of wheat bran in vivo
title_full Antimutagenic and anticarcinogenic effects of wheat bran in vivo
title_fullStr Antimutagenic and anticarcinogenic effects of wheat bran in vivo
title_full_unstemmed Antimutagenic and anticarcinogenic effects of wheat bran in vivo
title_sort Antimutagenic and anticarcinogenic effects of wheat bran in vivo
author Pesarini, J. R.
author_facet Pesarini, J. R.
Zaninetti, P. T.
Mauro, M. O. [UNESP]
Carreira, C. M.
Dichi, J. B.
Ribeiro, L. R. [UNESP]
Mantovani, M. S.
Oliveira, R. J.
author_role author
author2 Zaninetti, P. T.
Mauro, M. O. [UNESP]
Carreira, C. M.
Dichi, J. B.
Ribeiro, L. R. [UNESP]
Mantovani, M. S.
Oliveira, R. J.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Centro Universitário Filadélfia
Universidade Estadual Paulista (Unesp)
Universidade Federal de Mato Grosso do Sul (UFMS)
Universidade Estadual de Londrina (UEL)
dc.contributor.author.fl_str_mv Pesarini, J. R.
Zaninetti, P. T.
Mauro, M. O. [UNESP]
Carreira, C. M.
Dichi, J. B.
Ribeiro, L. R. [UNESP]
Mantovani, M. S.
Oliveira, R. J.
dc.subject.por.fl_str_mv Chemoprevention
Functional food
Triticum aestivum
Wheat bran
DNA
animal experiment
antineoplastic activity
apoptosis
cancer risk
cell cycle
cell proliferation
colon cancer
comet assay
controlled study
DNA damage
genotoxicity
in vivo study
male
micronucleus test
mouse
mutagenicity
nonhuman
wheat bran
topic Chemoprevention
Functional food
Triticum aestivum
Wheat bran
DNA
animal experiment
antineoplastic activity
apoptosis
cancer risk
cell cycle
cell proliferation
colon cancer
comet assay
controlled study
DNA damage
genotoxicity
in vivo study
male
micronucleus test
mouse
mutagenicity
nonhuman
wheat bran
description Previous studies in rodents treated with the pro-carcinogen 1,2-dimethylhydrazine suggested that the consumption of wheat bran protected against DNA damage in the colon and rectum. Based on this information, we evaluated wheat bran as a functional food in the prevention and treatment of colon cancer. We used the aberrant crypt focus assay to evaluate the anticarcinogenic potential of wheat bran (Triticum aestivum variety CD-104), the comet assay to evaluate its antigenotoxicity potential, and the micronucleus assay to evaluate its antimutagenic potential. The wheat bran gave good antimutagenic and anticarcinogenic responses; the DNA damage decreased from 90.30 to 26.37% and from 63.35 to 28.73%, respectively. However, the wheat bran did not significantly reduce genotoxicity. Further tests will be necessary, including tests in human beings, before this functional food can be recommended as an adjunct in the prevention and treatment of colon cancer. © FUNPEC-RP.
publishDate 2013
dc.date.none.fl_str_mv 2013-05-28
2014-05-27T11:29:33Z
2014-05-27T11:29:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4238/2013.May.14.5
Genetics and Molecular Research, v. 12, n. 2, p. 1646-1659, 2013.
1676-5680
http://hdl.handle.net/11449/75453
10.4238/2013.May.14.5
WOS:000320030100078
2-s2.0-84878104013
2-s2.0-84878104013.pdf
url http://dx.doi.org/10.4238/2013.May.14.5
http://hdl.handle.net/11449/75453
identifier_str_mv Genetics and Molecular Research, v. 12, n. 2, p. 1646-1659, 2013.
1676-5680
10.4238/2013.May.14.5
WOS:000320030100078
2-s2.0-84878104013
2-s2.0-84878104013.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genetics and Molecular Research
0,439
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1646-1659
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1799965602265169920

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