Susceptible hosts: a resort for parasites right in the eye of the immune response

Detalhes bibliográficos
Autor(a) principal: DOSREIS,GEORGE A.
Data de Publicação: 2000
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011
Resumo: Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed.
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spelling Susceptible hosts: a resort for parasites right in the eye of the immune responseTrypanosoma cruziLeishmania chagasiT lymphocytesCTLA-4apoptosistransforming growth factorTrypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed.Academia Brasileira de Ciências2000-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011Anais da Academia Brasileira de Ciências v.72 n.1 2000reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652000000100011info:eu-repo/semantics/openAccessDOSREIS,GEORGE A.eng2000-08-07T00:00:00Zoai:scielo:S0001-37652000000100011Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2000-08-07T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Susceptible hosts: a resort for parasites right in the eye of the immune response
title Susceptible hosts: a resort for parasites right in the eye of the immune response
spellingShingle Susceptible hosts: a resort for parasites right in the eye of the immune response
DOSREIS,GEORGE A.
Trypanosoma cruzi
Leishmania chagasi
T lymphocytes
CTLA-4
apoptosis
transforming growth factor
title_short Susceptible hosts: a resort for parasites right in the eye of the immune response
title_full Susceptible hosts: a resort for parasites right in the eye of the immune response
title_fullStr Susceptible hosts: a resort for parasites right in the eye of the immune response
title_full_unstemmed Susceptible hosts: a resort for parasites right in the eye of the immune response
title_sort Susceptible hosts: a resort for parasites right in the eye of the immune response
author DOSREIS,GEORGE A.
author_facet DOSREIS,GEORGE A.
author_role author
dc.contributor.author.fl_str_mv DOSREIS,GEORGE A.
dc.subject.por.fl_str_mv Trypanosoma cruzi
Leishmania chagasi
T lymphocytes
CTLA-4
apoptosis
transforming growth factor
topic Trypanosoma cruzi
Leishmania chagasi
T lymphocytes
CTLA-4
apoptosis
transforming growth factor
description Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed.
publishDate 2000
dc.date.none.fl_str_mv 2000-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652000000100011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.72 n.1 2000
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
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instname_str Academia Brasileira de Ciências (ABC)
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collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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