Susceptible hosts: a resort for parasites right in the eye of the immune response
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011 |
Resumo: | Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed. |
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Anais da Academia Brasileira de Ciências (Online) |
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Susceptible hosts: a resort for parasites right in the eye of the immune responseTrypanosoma cruziLeishmania chagasiT lymphocytesCTLA-4apoptosistransforming growth factorTrypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed.Academia Brasileira de Ciências2000-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011Anais da Academia Brasileira de Ciências v.72 n.1 2000reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652000000100011info:eu-repo/semantics/openAccessDOSREIS,GEORGE A.eng2000-08-07T00:00:00Zoai:scielo:S0001-37652000000100011Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2000-08-07T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Susceptible hosts: a resort for parasites right in the eye of the immune response |
title |
Susceptible hosts: a resort for parasites right in the eye of the immune response |
spellingShingle |
Susceptible hosts: a resort for parasites right in the eye of the immune response DOSREIS,GEORGE A. Trypanosoma cruzi Leishmania chagasi T lymphocytes CTLA-4 apoptosis transforming growth factor |
title_short |
Susceptible hosts: a resort for parasites right in the eye of the immune response |
title_full |
Susceptible hosts: a resort for parasites right in the eye of the immune response |
title_fullStr |
Susceptible hosts: a resort for parasites right in the eye of the immune response |
title_full_unstemmed |
Susceptible hosts: a resort for parasites right in the eye of the immune response |
title_sort |
Susceptible hosts: a resort for parasites right in the eye of the immune response |
author |
DOSREIS,GEORGE A. |
author_facet |
DOSREIS,GEORGE A. |
author_role |
author |
dc.contributor.author.fl_str_mv |
DOSREIS,GEORGE A. |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi Leishmania chagasi T lymphocytes CTLA-4 apoptosis transforming growth factor |
topic |
Trypanosoma cruzi Leishmania chagasi T lymphocytes CTLA-4 apoptosis transforming growth factor |
description |
Trypanosomatid protozoan parasites express an aggressive strategy of parasitism by infecting host macrophages and inducing extensive T-lymphocyte activation. One goal of such strategy is to drive the immune response of genetically susceptible hosts to a state of unresponsiveness regarding parasite killing. Unresponsiveness is achieved through different mechanisms, depending on the parasite species. In this brief review, recent findings on the molecular and cellular bases of the parasites' exploitation of host immune responses are discussed. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000100011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0001-37652000000100011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.72 n.1 2000 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302855384137728 |