Fatty acid synthase as a potential new therapeutic target for cervical cancer
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300705 |
Resumo: | Abstract Fatty acid synthase (FASN) is the rate-limiting enzyme for the de novo synthesis of fatty acids in the cytoplasm of tumour cells. Many tumour cells express high levels of FASN, and its expression is associated with a poorer prognosis. Cervical cancer is a major public health problem, representing the fourth most common cancer affecting women worldwide. To date, only a few in silico studies have correlated FASN expression with cervical cancer. This study aimed to investigate in vitro FASN expression in premalignant lesions and cervical cancer samples and the effects of a FASN inhibitor on cervical cancer cells. FASN expression was observed in all cervical cancer samples with increased expression at more advanced cervical cancer stages. The FASN inhibitor (orlistat) reduced the in vitro cell viability of cervical cancer cells (C-33A, ME-180, HeLa and SiHa) in a time-dependent manner and triggered apoptosis. FASN inhibitor also led to cell cycle arrest and autophagy. FASN may be a potential therapeutic target for cervical cancer, and medicinal chemists, pharmaceutical researchers and formulators should consider this finding in the development of new treatment approaches for this cancer type. |
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Fatty acid synthase as a potential new therapeutic target for cervical cancerFatty acid synthaseFASNCervical cancerOrlistatAbstract Fatty acid synthase (FASN) is the rate-limiting enzyme for the de novo synthesis of fatty acids in the cytoplasm of tumour cells. Many tumour cells express high levels of FASN, and its expression is associated with a poorer prognosis. Cervical cancer is a major public health problem, representing the fourth most common cancer affecting women worldwide. To date, only a few in silico studies have correlated FASN expression with cervical cancer. This study aimed to investigate in vitro FASN expression in premalignant lesions and cervical cancer samples and the effects of a FASN inhibitor on cervical cancer cells. FASN expression was observed in all cervical cancer samples with increased expression at more advanced cervical cancer stages. The FASN inhibitor (orlistat) reduced the in vitro cell viability of cervical cancer cells (C-33A, ME-180, HeLa and SiHa) in a time-dependent manner and triggered apoptosis. FASN inhibitor also led to cell cycle arrest and autophagy. FASN may be a potential therapeutic target for cervical cancer, and medicinal chemists, pharmaceutical researchers and formulators should consider this finding in the development of new treatment approaches for this cancer type.Academia Brasileira de Ciências2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300705Anais da Academia Brasileira de Ciências v.94 n.2 2022reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202220210670info:eu-repo/semantics/openAccessNASCIMENTO,JÉSSICAMARIOT,CAMILAVIANNA,DÉBORA R.B.KLIEMANN,LÚCIA M.CHAVES,PAULA S.LODA,MASSIMOBUFFON,ANDRÉIABECK,RUY C.R.PILGER,DIOGO A.eng2022-04-27T00:00:00Zoai:scielo:S0001-37652022000300705Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2022-04-27T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Fatty acid synthase as a potential new therapeutic target for cervical cancer |
title |
Fatty acid synthase as a potential new therapeutic target for cervical cancer |
spellingShingle |
Fatty acid synthase as a potential new therapeutic target for cervical cancer NASCIMENTO,JÉSSICA Fatty acid synthase FASN Cervical cancer Orlistat |
title_short |
Fatty acid synthase as a potential new therapeutic target for cervical cancer |
title_full |
Fatty acid synthase as a potential new therapeutic target for cervical cancer |
title_fullStr |
Fatty acid synthase as a potential new therapeutic target for cervical cancer |
title_full_unstemmed |
Fatty acid synthase as a potential new therapeutic target for cervical cancer |
title_sort |
Fatty acid synthase as a potential new therapeutic target for cervical cancer |
author |
NASCIMENTO,JÉSSICA |
author_facet |
NASCIMENTO,JÉSSICA MARIOT,CAMILA VIANNA,DÉBORA R.B. KLIEMANN,LÚCIA M. CHAVES,PAULA S. LODA,MASSIMO BUFFON,ANDRÉIA BECK,RUY C.R. PILGER,DIOGO A. |
author_role |
author |
author2 |
MARIOT,CAMILA VIANNA,DÉBORA R.B. KLIEMANN,LÚCIA M. CHAVES,PAULA S. LODA,MASSIMO BUFFON,ANDRÉIA BECK,RUY C.R. PILGER,DIOGO A. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
NASCIMENTO,JÉSSICA MARIOT,CAMILA VIANNA,DÉBORA R.B. KLIEMANN,LÚCIA M. CHAVES,PAULA S. LODA,MASSIMO BUFFON,ANDRÉIA BECK,RUY C.R. PILGER,DIOGO A. |
dc.subject.por.fl_str_mv |
Fatty acid synthase FASN Cervical cancer Orlistat |
topic |
Fatty acid synthase FASN Cervical cancer Orlistat |
description |
Abstract Fatty acid synthase (FASN) is the rate-limiting enzyme for the de novo synthesis of fatty acids in the cytoplasm of tumour cells. Many tumour cells express high levels of FASN, and its expression is associated with a poorer prognosis. Cervical cancer is a major public health problem, representing the fourth most common cancer affecting women worldwide. To date, only a few in silico studies have correlated FASN expression with cervical cancer. This study aimed to investigate in vitro FASN expression in premalignant lesions and cervical cancer samples and the effects of a FASN inhibitor on cervical cancer cells. FASN expression was observed in all cervical cancer samples with increased expression at more advanced cervical cancer stages. The FASN inhibitor (orlistat) reduced the in vitro cell viability of cervical cancer cells (C-33A, ME-180, HeLa and SiHa) in a time-dependent manner and triggered apoptosis. FASN inhibitor also led to cell cycle arrest and autophagy. FASN may be a potential therapeutic target for cervical cancer, and medicinal chemists, pharmaceutical researchers and formulators should consider this finding in the development of new treatment approaches for this cancer type. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300705 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000300705 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765202220210670 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.94 n.2 2022 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302871978901504 |