Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700627 |
Resumo: | Abstract Abstract: Sepsis is a life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Inflammation and oxidative stress are intrinsically related to sepsis progression and organ failure. Vitamin B6 is an important cellular cofactor for metabolic processes and has anti-inflammatory and antioxidant properties. We aimed at evaluating the effect of vit B6 on inflammation and oxidative stress markers in the liver and lung of rats subjected to a relevant animal model of polymicrobial sepsis. Adult male Wistar rats were submitted to cecal ligation and perforation model and immediately after sepsis induction, vit B6 was administered as a single dose (600 mg/kg, subcutaneous). Twenty-four hours later, the lung and liver were harvest for neutrophil infiltration, oxidative markers to lipids and protein and antioxidant activity of endogenous enzyme. Vitamin B6 diminished neutrophil infiltration in both organs, oxidative markers in the liver and restored catalase activity levels in the lung of septic animals. Vitamin B6 exerts anti-inflammatory and antioxidant effects in peripheral organs after polymicrobial sepsis. |
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Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsissepsisvitamin B6oxidative stressantioxidantAbstract Abstract: Sepsis is a life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Inflammation and oxidative stress are intrinsically related to sepsis progression and organ failure. Vitamin B6 is an important cellular cofactor for metabolic processes and has anti-inflammatory and antioxidant properties. We aimed at evaluating the effect of vit B6 on inflammation and oxidative stress markers in the liver and lung of rats subjected to a relevant animal model of polymicrobial sepsis. Adult male Wistar rats were submitted to cecal ligation and perforation model and immediately after sepsis induction, vit B6 was administered as a single dose (600 mg/kg, subcutaneous). Twenty-four hours later, the lung and liver were harvest for neutrophil infiltration, oxidative markers to lipids and protein and antioxidant activity of endogenous enzyme. Vitamin B6 diminished neutrophil infiltration in both organs, oxidative markers in the liver and restored catalase activity levels in the lung of septic animals. Vitamin B6 exerts anti-inflammatory and antioxidant effects in peripheral organs after polymicrobial sepsis.Academia Brasileira de Ciências2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700627Anais da Academia Brasileira de Ciências v.91 n.4 2019reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201920190434info:eu-repo/semantics/openAccessGIUSTINA,AMANDA D.DANIELSKI,LUCINÉIA G.NOVOCHADLO,MICHELE M.GOLDIM,MARIANA P.S.JOAQUIM,LARISSAMETZKER,KIUANNE L.L.CARLI,RAQUEL JACONI DEDENICOL,TAISCIDREIRA,THAINAVIEIRA,THAYNANPETRONILHO,FABRICIAeng2019-12-10T00:00:00Zoai:scielo:S0001-37652019000700627Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2019-12-10T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis |
title |
Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis |
spellingShingle |
Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis GIUSTINA,AMANDA D. sepsis vitamin B6 oxidative stress antioxidant |
title_short |
Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis |
title_full |
Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis |
title_fullStr |
Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis |
title_full_unstemmed |
Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis |
title_sort |
Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis |
author |
GIUSTINA,AMANDA D. |
author_facet |
GIUSTINA,AMANDA D. DANIELSKI,LUCINÉIA G. NOVOCHADLO,MICHELE M. GOLDIM,MARIANA P.S. JOAQUIM,LARISSA METZKER,KIUANNE L.L. CARLI,RAQUEL JACONI DE DENICOL,TAIS CIDREIRA,THAINA VIEIRA,THAYNAN PETRONILHO,FABRICIA |
author_role |
author |
author2 |
DANIELSKI,LUCINÉIA G. NOVOCHADLO,MICHELE M. GOLDIM,MARIANA P.S. JOAQUIM,LARISSA METZKER,KIUANNE L.L. CARLI,RAQUEL JACONI DE DENICOL,TAIS CIDREIRA,THAINA VIEIRA,THAYNAN PETRONILHO,FABRICIA |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
GIUSTINA,AMANDA D. DANIELSKI,LUCINÉIA G. NOVOCHADLO,MICHELE M. GOLDIM,MARIANA P.S. JOAQUIM,LARISSA METZKER,KIUANNE L.L. CARLI,RAQUEL JACONI DE DENICOL,TAIS CIDREIRA,THAINA VIEIRA,THAYNAN PETRONILHO,FABRICIA |
dc.subject.por.fl_str_mv |
sepsis vitamin B6 oxidative stress antioxidant |
topic |
sepsis vitamin B6 oxidative stress antioxidant |
description |
Abstract Abstract: Sepsis is a life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Inflammation and oxidative stress are intrinsically related to sepsis progression and organ failure. Vitamin B6 is an important cellular cofactor for metabolic processes and has anti-inflammatory and antioxidant properties. We aimed at evaluating the effect of vit B6 on inflammation and oxidative stress markers in the liver and lung of rats subjected to a relevant animal model of polymicrobial sepsis. Adult male Wistar rats were submitted to cecal ligation and perforation model and immediately after sepsis induction, vit B6 was administered as a single dose (600 mg/kg, subcutaneous). Twenty-four hours later, the lung and liver were harvest for neutrophil infiltration, oxidative markers to lipids and protein and antioxidant activity of endogenous enzyme. Vitamin B6 diminished neutrophil infiltration in both organs, oxidative markers in the liver and restored catalase activity levels in the lung of septic animals. Vitamin B6 exerts anti-inflammatory and antioxidant effects in peripheral organs after polymicrobial sepsis. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700627 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700627 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201920190434 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.91 n.4 2019 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302868129579008 |