The lizard cerebral cortex as a model to study neuronal regeneration
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000100006 |
Resumo: | The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and, secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regeneration of an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only case to our knowledge of the regeneration of an amniote central nervous centre by new neuron production and neo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events. |
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The lizard cerebral cortex as a model to study neuronal regenerationmedial cortexhippocampuspostnatal neurogenesisneural stem cellszincregenerationThe medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and, secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regeneration of an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only case to our knowledge of the regeneration of an amniote central nervous centre by new neuron production and neo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events.Academia Brasileira de Ciências2002-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000100006Anais da Academia Brasileira de Ciências v.74 n.1 2002reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652002000100006info:eu-repo/semantics/openAccessLOPEZ-GARCIA,CARLOSMOLOWNY,ASUNCIONNACHER,JUANPONSODA,XAVIERSANCHO-BIELSA,FRANCISCOALONSO-LLOSA,GREGORIeng2002-05-24T00:00:00Zoai:scielo:S0001-37652002000100006Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2002-05-24T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
The lizard cerebral cortex as a model to study neuronal regeneration |
title |
The lizard cerebral cortex as a model to study neuronal regeneration |
spellingShingle |
The lizard cerebral cortex as a model to study neuronal regeneration LOPEZ-GARCIA,CARLOS medial cortex hippocampus postnatal neurogenesis neural stem cells zinc regeneration |
title_short |
The lizard cerebral cortex as a model to study neuronal regeneration |
title_full |
The lizard cerebral cortex as a model to study neuronal regeneration |
title_fullStr |
The lizard cerebral cortex as a model to study neuronal regeneration |
title_full_unstemmed |
The lizard cerebral cortex as a model to study neuronal regeneration |
title_sort |
The lizard cerebral cortex as a model to study neuronal regeneration |
author |
LOPEZ-GARCIA,CARLOS |
author_facet |
LOPEZ-GARCIA,CARLOS MOLOWNY,ASUNCION NACHER,JUAN PONSODA,XAVIER SANCHO-BIELSA,FRANCISCO ALONSO-LLOSA,GREGORI |
author_role |
author |
author2 |
MOLOWNY,ASUNCION NACHER,JUAN PONSODA,XAVIER SANCHO-BIELSA,FRANCISCO ALONSO-LLOSA,GREGORI |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
LOPEZ-GARCIA,CARLOS MOLOWNY,ASUNCION NACHER,JUAN PONSODA,XAVIER SANCHO-BIELSA,FRANCISCO ALONSO-LLOSA,GREGORI |
dc.subject.por.fl_str_mv |
medial cortex hippocampus postnatal neurogenesis neural stem cells zinc regeneration |
topic |
medial cortex hippocampus postnatal neurogenesis neural stem cells zinc regeneration |
description |
The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and, secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regeneration of an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only case to our knowledge of the regeneration of an amniote central nervous centre by new neuron production and neo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000100006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000100006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0001-37652002000100006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.74 n.1 2002 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
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ABC |
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ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
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Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
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||aabc@abc.org.br |
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1754302855742750720 |